{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:12:17Z","timestamp":1791825137577,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijrobp.2025.02.013","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:55:54Z","timestamp":1740207354000},"page":"1272-1281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development and Validation of a Prediction Model for Cardiac Events in Patients With Hepatocellular Carcinoma Undergoing Stereotactic Body Radiation Therapy"],"prefix":"10.1016","volume":"122","author":[{"given":"Hye In","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeman","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungchul","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngmoon","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-hong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Kyu","family":"Chie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hak","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Cheol","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5138-3051","authenticated-orcid":false,"given":"Sang Min","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.02.013_bib0001","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1159\/000509424","article-title":"Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition)","volume":"9","author":"Zhou","year":"2020","journal-title":"Liver Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0002","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4251\/wjgo.v11.i5.367","article-title":"Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review","volume":"11","author":"Gerum","year":"2019","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0003","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma: From infancy to ongoing maturity","volume":"4","author":"Lewis","year":"2022","journal-title":"JHEP Rep"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0004","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.prro.2021.09.004","article-title":"External beam radiation therapy for primary liver cancers: An ASTRO clinical practice guideline","volume":"12","author":"Apisarnthanarax","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijrobp.2023.08.015","article-title":"Stereotactic body radiation therapy for hepatocellular carcinoma: Meta-analysis and International Stereotactic Radiosurgery Society practice guidelines","volume":"118","author":"Bae","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17998\/jlc.2022.11.07","article-title":"Korean Liver Cancer Association (KLCA) and National Cancer Center (NCC) Korea. 2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma","volume":"23","year":"2023","journal-title":"J Liver Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0007","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0008","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1200\/JCO.2016.72.0722","article-title":"Estimating the risks of breast cancer radiotherapy: Evidence from modern radiation doses to the lungs and heart and from previous randomized trials","volume":"35","author":"Taylor","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0009","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1016\/j.prro.2021.03.005","article-title":"Organ at risk dose constraints in SABR: A systematic review of active clinical trials","volume":"11","author":"Gerhard","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaccao.2021.06.007","article-title":"Past, present, and future of radiation-induced cardiotoxicity: Refinements in targeting, surveillance, and risk stratification","volume":"3","author":"Bergom","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0011","first-page":"155","article-title":"Common Terminology Criteria for Adverse Events (CTCAE) v.5.0","year":"2017","journal-title":"Cancer Ther. Eval. Progr"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0012","doi-asserted-by":"crossref","DOI":"10.1148\/ryai.230024","article-title":"TotalSegmentator: Robust segmentation of 104 anatomic structures in CT images","volume":"5","author":"Wasserthal","year":"2023","journal-title":"Radiol Artif Intell"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0013","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3350\/cmh.2020.0038","article-title":"Stereotactic body radiation therapy for small (\u22645 cm) hepatocellular carcinoma not amenable to curative treatment: Results of a single-arm, phase ii clinical trial","volume":"26","author":"Yoon","year":"2020","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0014","doi-asserted-by":"crossref","first-page":"136","DOI":"10.17998\/jlc.2022.08.18","article-title":"Stereotactic body radiation therapy for elderly patients with small hepatocellular carcinoma: A retrospective observational study","volume":"22","author":"Jang","year":"2022","journal-title":"J Liver Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0015","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.3748\/wjg.v20.i12.3100","article-title":"Role of stereotactic body radiation therapy for hepatocellular carcinoma","volume":"20","author":"Sanuki","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0016","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jtho.2020.11.002","article-title":"Cardiac toxicity of thoracic radiotherapy: Existing evidence and future directions","volume":"16","author":"Banfill","year":"2021","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0017","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.radonc.2017.04.017","article-title":"Dose to heart substructures is associated with non-cancer death after SBRT in stage I-II NSCLC patients","volume":"123","author":"Stam","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0018","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1016\/j.cllc.2017.08.002","article-title":"Survival impact of cardiac dose following lung stereotactic body radiotherapy","volume":"19","author":"Wong","year":"2018","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0019","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3390\/cancers14061391","article-title":"Right atrial dose is associated with worse outcome in patients undergoing definitive stereotactic body radiation therapy for central lung tumors","volume":"14","author":"Farrugia","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0020","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cllc.2019.10.010","article-title":"Effect of radiation doses to the heart on survival for stereotactic ablative radiotherapy for early-stage non-small-cell lung cancer: An artificial neural network approach","volume":"21","author":"Chan","year":"2020","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0021","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.21037\/jtd.2018.04.42","article-title":"Cardiac radiation dose distribution, cardiac events and mortality in early-stage lung cancer treated with stereotactic body radiation therapy (SBRT)","volume":"10","author":"Reshko","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0022","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cllc.2016.12.007","article-title":"Cardiac dose and survival after stereotactic body radiotherapy for early-stage non-small-cell lung cancer","volume":"18","author":"Tembhekar","year":"2017","journal-title":"Clin Lung Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0023","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/jamaoncol.2020.6332","article-title":"Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non-small cell lung cancer","volume":"7","author":"Atkins","year":"2021","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0024","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1200\/JCO.2016.69.8480","article-title":"Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose distributions to cardiac substructures","volume":"35","author":"van den Bogaard","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0025","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jamaoncol.2022.4202","article-title":"Association of sinoatrial node radiation dose with atrial fibrillation and mortality in patients with lung cancer","volume":"8","author":"Kim","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0026","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.jtho.2018.05.028","article-title":"Dosimetric predictors of symptomatic cardiac events after conventional-dose chemoradiation therapy for inoperable NSCLC","volume":"13","author":"Yegya-Raman","year":"2018","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0027","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejca.2017.07.053","article-title":"Radiation dose to heart base linked with poorer survival in lung cancer patients","volume":"85","author":"McWilliam","year":"2017","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0028","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.radonc.2017.10.001","article-title":"Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for stage III non-small-cell lung cancer","volume":"125","author":"Wang","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0029","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijrobp.2017.04.026","article-title":"The impact of cardiac radiation dosimetry on survival after radiation therapy for non-small cell lung cancer","volume":"99","author":"Vivekanandan","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0030","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ijrobp.2018.12.044","article-title":"Is the importance of heart dose overstated in the treatment of non-small cell lung cancer? A systematic review of the literature","volume":"104","author":"Zhang","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0031","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1093\/eurheartj\/ehz766","article-title":"A population-based study of cardiovascular disease mortality risk in US cancer patients","volume":"40","author":"Sturgeon","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ijrobp.2025.02.013_bib0032","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","article-title":"2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur Heart J"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625001555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625001555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:25:27Z","timestamp":1752643527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625001555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0360301625001555"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.02.013","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and Validation of a Prediction Model for Cardiac Events in Patients With Hepatocellular Carcinoma Undergoing Stereotactic Body Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}