{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:10:06Z","timestamp":1793329806895,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijrobp.2025.03.015","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T20:57:17Z","timestamp":1741899437000},"page":"1292-1300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phase 1\/2 Dose Escalation Trial of 3-Fraction Stereotactic Radiosurgery for Resection Cavities from Large Brain Metastases"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2523-4164","authenticated-orcid":false,"given":"Daniella","family":"Klebaner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erqi L.","family":"Pollom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Rahimy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris C.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Y.H.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-7063","authenticated-orcid":false,"given":"Scott G.","family":"Soltys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.03.015_bib0001","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/neuonc\/nox077","article-title":"Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: A population-based study","volume":"19","author":"Cagney","year":"2017","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0002","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.prro.2022.02.003","article-title":"Radiation therapy for brain metastases: An ASTRO clinical practice guideline","volume":"12","author":"Gondi","year":"2022","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0003","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.annonc.2021.07.016","article-title":"EANO\u2013ESMO clinical practice guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours","volume":"32","author":"Le Rhun","year":"2021","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0004","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1200\/JCO.21.02314","article-title":"Treatment for brain metastases: ASCO-SNO-ASTRO guideline","volume":"40","author":"Vogelbaum","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0005","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1093\/neuonc\/noaa192","article-title":"Executive summary from American Radium Society's appropriate use criteria on neurocognition after stereotactic radiosurgery for multiple brain metastases","volume":"22","author":"Milano","year":"2020","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0006","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijrobp.2020.08.013","article-title":"Single- and multifraction stereotactic radiosurgery dose\/volume tolerances of the brain","volume":"110","author":"Milano","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0007","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3171\/2014.10.JNS141610","article-title":"Adverse radiation effect after stereotactic radiosurgery for brain metastases: Incidence, time course, and risk factors","volume":"123","author":"Sneed","year":"2015","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0008","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijrobp.2020.10.034","article-title":"Tumor control probability of radiosurgery and fractionated stereotactic radiosurgery for brain metastases","volume":"110","author":"Redmond","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0009","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3171\/jns.2006.104.6.907","article-title":"Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor margin","volume":"104","author":"Vogelbaum","year":"2006","journal-title":"J Neurosurg"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.radonc.2011.01.011","article-title":"Dose-effect relation in stereotactic radiotherapy for brain metastases. A systematic review","volume":"98","author":"Wiggenraad","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0011","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/S1470-2045(17)30414-X","article-title":"Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: A single-centre, randomised, controlled, phase 3 trial","volume":"18","author":"Mahajan","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0012","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S1470-2045(17)30441-2","article-title":"Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C\/CEC\u00b73): A multicentre, randomised, controlled, phase 3 trial","volume":"18","author":"Brown","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0013","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13014-017-0840-x","article-title":"Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: A systematic review and meta-analysis","volume":"12","author":"Lamba","year":"2017","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0014","first-page":"291","article-title":"What is the Optimal Treatment of Large Brain Metastases? An argument for a multidisciplinary approach","volume":"47","author":"Choi","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0360-3016(99)00507-6","article-title":"Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05","volume":"47","author":"Shaw","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0016","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ijrobp.2018.10.038","article-title":"Single versus multifraction stereotactic radiosurgery for large brain metastases: An international meta-analysis of 24 trials","volume":"103","author":"Lehrer","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0017","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.ijrobp.2016.08.039","article-title":"Association between radiation necrosis and tumor biology after stereotactic radiosurgery for brain metastasis","volume":"96","author":"Miller","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0018","first-page":"1060","article-title":"Stereotactic radiosurgery for resected brain metastases: Single-institutional experience of over 500 cavities","volume":"96","author":"Shi","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0019","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijrobp.2011.12.009","article-title":"Stereotactic radiosurgery of the postoperative resection cavity for brain metastases: Prospective evaluation of target margin on tumor control","volume":"84","author":"Choi","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0020","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1016\/j.prro.2020.04.009","article-title":"Stereotactic radiosurgery for resected brain metastases: Does the surgival corridor need to be targeted?","volume":"10","author":"Shi","year":"2020","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0021","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/COC.0000000000000868","article-title":"Phase I\/II dose-escalation trial of 3-fraction stereotactic radiosurgry for resection cavities from large brain metastases: health-related quality of life outcomes","volume":"44","author":"Rahimy","year":"2021","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0022","doi-asserted-by":"crossref","first-page":"ii38","DOI":"10.1093\/neuonc\/now301","article-title":"The radiosurgery fractionation quandary: Single fraction or hypofractionation?","volume":"19","author":"Kirkpatrick","year":"2017","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0023","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.ijrobp.2016.03.013","article-title":"Single-fraction versus multifraction (3 \u00d7 9 Gy) stereotactic radiosurgery for large (>2 cm) brain metastases: A comparative analysis of local control and risk of radiation-induced brain necrosis","volume":"95","author":"Minniti","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0024","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0360-3016(99)00513-1","article-title":"Development of a model to predict permanent symptomatic postradiosurgery injury for arteriovenous malformation patients. Arteriovenous Malformation Radiosurgery Study Group","volume":"46","author":"Flickinger","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11060-018-2885-6","article-title":"Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: Improved local control with higher BED10","volume":"139","author":"Kumar","year":"2018","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0026","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijrobp.2023.07.040","article-title":"Dose-volume tolerance of the brain and predictors of radiation necrosis after 3-fraction radiosurgery for brain metastases: A large single-institutional analysis","volume":"118","author":"Upadhyay","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0027","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.ijrobp.2023.06.846","article-title":"Clinical outcomes of patients with brain metastases from colorectal cancer treated with stereotactic radiosurgery","volume":"117","author":"Bommireddy","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0028","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0360-3016(95)02106-X","article-title":"Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: Initial report of Radiation Therapy Oncology Group protocol (90-05)","volume":"34","author":"Shaw","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0029","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ijrobp.2019.10.002","article-title":"Nodular leptomeningeal disease-A distinct pattern of recurrence after postresection stereotactic radiosurgery for brain metastases: A multi-institutional study of interobserver reliability","volume":"106","author":"Turner","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0030","article-title":"Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases: A multi-institutional analysis","volume":"6","author":"Prabhu","year":"2021","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0031","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jamaoncol.2020.4630","article-title":"Multi-institutional analysis of prognostic factors and outcomes after hypofractionated stereotactic radiotherapy to the resection cavity in patients with brain metastases","volume":"6","author":"Eitz","year":"2020","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0032","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ijrobp.2022.09.012","article-title":"Patterns of failure after stereotactic radiosurgery vs. whole brain radiotherapy for resected brain metastases: Central imaging review of the N107C\/CEC.3 (Alliance) phase III clinical trial","volume":"114","author":"Breen","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0033","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.radonc.2016.10.005","article-title":"Stereotactic radiotherapy of the tumor bed compared to whole brain radiotherapy after surgery of single brain metastasis: Results from a randomized trial","volume":"121","author":"K\u0119pka","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0034","unstructured":"Brown PD. Single fraction stereotactic radiosurgery compared with fractionated stereotactic radiosurgery in treating patients with resected metastatic brain disease. ClinicalTrials.gov identifier: NCT04114981. Available at:https:\/\/clinicaltrials.gov\/study\/NCT04114981?tab=table. Accessed August 21, 2024."},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0035","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1186\/s12885-023-11202-9","article-title":"Hypofractionated stereotactic radiotherapy (HFSRT) versus single fraction stereotactic radiosurgery (SRS) to the resection cavity of brain metastases after surgical resection (SATURNUS): Study protocol for a randomized phase III trial","volume":"23","author":"Waltenberger","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0036","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/neuonc\/noae076","article-title":"Phase I trial of dose escalation for preoperative stereotactic radiosurgery for patients with large brain metastases","volume":"26","author":"Murphy","year":"2024","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0037","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijrobp.2022.07.036","article-title":"The art of radiation therapy: The necessary risk of radiation necrosis for durable control of brain metastases","volume":"115","author":"Milano","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.015_bib0038","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.ijrobp.2021.07.085","article-title":"Phase I dose escalation trial of hypofractionated radiosurgery for large intact or resected brain metastases","volume":"111","author":"Eaton","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:25:38Z","timestamp":1752643538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625002421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0360301625002421"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.015","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase 1\/2 Dose Escalation Trial of 3-Fraction Stereotactic Radiosurgery for Resection Cavities from Large Brain Metastases","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}