{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:51:55Z","timestamp":1780930315285,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["SB\/1SE5722N"],"award-info":[{"award-number":["SB\/1SE5722N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ijrobp.2025.03.019","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T04:07:26Z","timestamp":1742616446000},"page":"631-642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Structural Network Hubs as Potential Organs at Risk in Glioma Patients After Radiation Therapy"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-1816","authenticated-orcid":false,"given":"Laurien","family":"De Roeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Blommaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sunaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieselotte","family":"Lauwens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"De Vleeschouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Sleurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.03.019_bib0001","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nrneurol.2016.185","article-title":"Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours","volume":"13","author":"Makale","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0002","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1053\/j.seminoncol.2004.07.013","article-title":"Cognitive sequelae of brain radiation in adults","volume":"31","author":"Laack","year":"2004","journal-title":"Semin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0003","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0140-6736(02)11398-5","article-title":"Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: A comparative study","volume":"360","author":"Klein","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0004","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.radonc.2021.04.023","article-title":"Effects of brain radiotherapy on cognitive performance in adult low-grade glioma patients: A systematic review","volume":"160","author":"Koutsarnakis","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1212\/WNL.59.1.40","article-title":"Late cognitive and radiographic changes related to radiotherapy: Initial prospective findings","volume":"59","author":"Armstrong","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0006","doi-asserted-by":"crossref","first-page":"CNS84","DOI":"10.2217\/cns-2022-0002","article-title":"Daily functioning in glioma survivors: Associations with cognitive function, psychological factors and quality of life","volume":"11","author":"Van Dyk","year":"2022","journal-title":"CNS Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0007","first-page":"40","article-title":"The association between cognitive functioning and health-related quality of life in low-grade glioma patients","volume":"1","author":"Boele","year":"2014","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0008","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00701-014-2115-8","article-title":"Tumour and surgery effects on cognitive functioning in high-grade glioma patients","volume":"156","author":"Habets","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0009","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11060-019-03259-z","article-title":"Association between tumor location and neurocognitive functioning using tumor localization maps","volume":"144","author":"Habets","year":"2019","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1474-4422(04)00680-5","article-title":"Cognitive deficits in adult patients with brain tumours","volume":"3","author":"Taphoorn","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.943600","article-title":"Influences on cognitive outcomes in adult patients with gliomas: A systematic review","volume":"12","author":"Kirkman","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0012","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s10072-023-06673-4","article-title":"Factors affecting cognitive functions of patients with high-grade gliomas: A systematic review","volume":"44","author":"Tariq","year":"2023","journal-title":"Neurol Sci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0013","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S1474-4422(09)70204-2","article-title":"Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: Long-term follow-up","volume":"8","author":"Douw","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0014","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1200\/JCO.19.02767","article-title":"Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: Phase III trial NRG oncology CC001","volume":"38","author":"Brown","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0015","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.ijrobp.2007.05.076","article-title":"A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy","volume":"69","author":"Butler","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0016","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1200\/JCO.2014.58.4508","article-title":"Donepezil for irradiated brain tumor survivors: A phase III randomized placebo-controlled clinical trial","volume":"33","author":"Rapp","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0017","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/neuonc\/not114","article-title":"Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: A randomized, double-blind, placebo-controlled trial","volume":"15","author":"Brown","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0018","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20190237","article-title":"Proton therapy for brain tumours in the area of evidence-based medicine","volume":"93","author":"Weber","year":"2020","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2020.03.023","article-title":"Cognitive impairment following radiation to hippocampus and other brain structures in adults with primary brain tumours","volume":"148","author":"Haldbo-Classen","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0020","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.adro.2017.08.013","article-title":"Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation","volume":"2","author":"Okoukoni","year":"2017","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0021","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1016\/j.ijrobp.2012.11.031","article-title":"Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors","volume":"85","author":"Gondi","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0022","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.radonc.2021.05.013","article-title":"Update of the EPTN atlas for CT- and MR-based contouring in neuro-oncology","volume":"160","author":"Eekers","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0023","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijrobp.2020.12.046","article-title":"Microstructural injury to corpus callosum and intrahemispheric white matter tracts correlate with attention and processing speed decline after brain radiation","volume":"110","author":"Huynh-Le","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0024","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ijrobp.2023.05.026","article-title":"Dose-dependent atrophy in bilateral amygdalae and nuclei after brain radiation therapy and its association with mood and memory outcomes on a longitudinal clinical trial","volume":"117","author":"Unnikrishnan","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0025","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/EJE-11-0749","article-title":"Cognitive performance after postoperative pituitary radiotherapy: A dosimetric study of the hippocampus and the prefrontal cortex","volume":"166","author":"Brummelman","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0026","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/neuonc\/noz068","article-title":"Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: A 10-year neurocognitive longitudinal study","volume":"21","author":"Acharya","year":"2019","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0027","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.radonc.2019.04.027","article-title":"Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma","volume":"137","author":"Tabrizi","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0028","first-page":"506","article-title":"Multiscale network neuroscience in neuro-oncology: How tumors, brain networks, and behavior connect across scales","volume":"10","author":"Maas","year":"2023","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0029","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuroimage.2013.03.023","article-title":"The human connectome: Origins and challenges","volume":"80","author":"Sporns","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: Graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0031","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"van den Heuvel","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0032","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1093\/brain\/awaa277","article-title":"Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma","volume":"143","author":"Mandal","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0033","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nicl.2018.08.015","article-title":"White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors","volume":"20","author":"Na","year":"2018","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0034","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137","author":"Crossley","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0035","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0036","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrn3801","article-title":"Modern network science of neurological disorders","volume":"15","author":"Stam","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102177","article-title":"Functional and structural connectivity substrates of cognitive performance in relapsing remitting multiple sclerosis with mild disability","volume":"25","author":"Has Silemek","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0038","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1148\/radiol.2016160274","article-title":"Structural brain connectome and cognitive impairment in Parkinson disease","volume":"283","author":"Galantucci","year":"2017","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0039","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/brain.2017.0494","article-title":"Altered network topology in patients with primary brain tumors after fractionated radiotherapy","volume":"7","author":"Bahrami","year":"2017","journal-title":"Brain Connect"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0040","doi-asserted-by":"crossref","first-page":"224","DOI":"10.11648\/j.ajcem.20170506.17","article-title":"Radiation-induced changes in structural network in patients with nasopharyngeal carcinoma","volume":"5","author":"Tian","year":"2017","journal-title":"Am J Clin Exp Med"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0041","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.radonc.2021.05.028","article-title":"Brain network hubs and cognitive performance of survivors of childhood infratentorial tumors","volume":"161","author":"Sleurs","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0042","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1076\/clin.12.1.43.1726","article-title":"Hopkins verbal learning test - revised: Normative data and analysis of inter-form and test-retest reliability","volume":"12","author":"Benedict","year":"1998","journal-title":"Clin Neuropsychol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0043","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/arclin\/11.4.329","article-title":"Benton controlled oral word association test: Reliability and updated norms","volume":"11","author":"Ruff","year":"1996","journal-title":"Arch Clin Neuropsychol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0044","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bandc.2004.12.004","article-title":"A new method of administering the grooved pegboard test: Performance as a function of handedness and sex","volume":"58","author":"Bryden","year":"2005","journal-title":"Brain Cogn"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0045","series-title":"Essentials of WAIS-IV Assessment","author":"Lichtenberger","year":"2006"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0046","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/nprot.2006.390","article-title":"Administration and interpretation of the trail making test","volume":"1","author":"Bowie","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0047","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3389\/fpsyg.2017.00557","article-title":"The stroop color and word test","volume":"8","author":"Scarpina","year":"2017","journal-title":"Front Psychol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0048","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nrneurol.2014.181","article-title":"Classifying neurocognitive disorders: The DSM-5 approach","volume":"10","author":"Sachdev","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0049","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/1073191117727346","article-title":"Evaluation of normative data of a widely used computerized neuropsychological battery: Applicability and effects of sociodemographic variables in a Dutch sample","volume":"27","author":"Rijnen","year":"2020","journal-title":"Assessment"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S1470-2045(10)70294-1","article-title":"International cognition and cancer task force recommendations to harmonise studies of cognitive function in patients with cancer","volume":"12","author":"Wefel","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0051","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s11548-021-02420-2","article-title":"A self-supervised learning strategy for postoperative brain cavity segmentation simulating resections","volume":"16","author":"P\u00e9rez-Garc\u00eda","year":"2021","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0052","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1470-2045(19)30098-1","article-title":"Automated quantitative tumour response assessment of MRI in neuro-oncology with artificial neural networks: A multicentre, retrospective study","volume":"20","author":"Kickingereder","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117012","article-title":"FastSurfer - A fast and accurate deep learning based neuroimaging pipeline","volume":"219","author":"Henschel","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0054","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116137","article-title":"MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"Tournier","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0056","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0057","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/0284186X.2018.1557786","article-title":"Long-term cognitive dysfunction after radiation therapy for primary brain tumors","volume":"58","author":"Haldbo-Classen","year":"2019","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0058","first-page":"22","article-title":"The posterior cerebellum, a new organ at risk?","volume":"8","author":"Eekers","year":"2017","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0059","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1007\/s11682-019-00224-2","article-title":"Altered properties of brain white matter structural networks in patients with nasopharyngeal carcinoma after radiotherapy","volume":"14","author":"Chen","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1059320","article-title":"Structural network alterations in patients with nasopharyngeal carcinoma after radiotherapy: A 1-year longitudinal study","volume":"16","author":"Zhang","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0061","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/brain\/awv075","article-title":"Disconnection of network hubs and cognitive impairment after traumatic brain injury","volume":"138","author":"Fagerholm","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0062","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1017\/S1355617714000812","article-title":"Disrupted structural connectome is associated with both psychometric and real-world neuropsychological impairment in diffuse traumatic brain injury","volume":"20","author":"Kim","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0063","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"van den Heuvel","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0064","doi-asserted-by":"crossref","first-page":"3810","DOI":"10.1200\/JCO.2014.57.2909","article-title":"Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): A phase II multi-institutional trial","volume":"32","author":"Gondi","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0065","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3389\/fonc.2019.00991","article-title":"Evaluation of the hippocampal normal tissue complication model in a prospective cohort of low grade glioma patients\u2014An analysis within the EORTC 22033 clinical trial","volume":"9","author":"Jaspers","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0066","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijrobp.2023.04.030","article-title":"Sustained preservation of cognition and prevention of patient-reported symptoms with hippocampal avoidance during whole-brain radiation therapy for brain metastases: Final results of NRG oncology CC001","volume":"117","author":"Gondi","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0067","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jtho.2020.12.024","article-title":"Phase 3 randomized trial of prophylactic cranial irradiation with or without hippocampus avoidance in SCLC (NCT01780675)","volume":"16","author":"Belderbos","year":"2021","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0068","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/neuonc\/noaa076","article-title":"Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: Mature data from a prospective trial in young patients with brain tumors","volume":"22","author":"Goda","year":"2020","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0069","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11060-016-2328-1","article-title":"The effect of IDH1 mutation on the structural connectome in malignant astrocytoma","volume":"131","author":"Kesler","year":"2017","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0070","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41597-022-01806-4","article-title":"Pre- and post-surgery brain tumor multimodal magnetic resonance imaging data optimized for large scale computational modelling","volume":"9","author":"Aerts","year":"2022","journal-title":"Sci Data"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0071","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1177\/1352458519845105","article-title":"A multi-shell multi-tissue diffusion study of brain connectivity in early multiple sclerosis","volume":"26","author":"Tur","year":"2020","journal-title":"Mult Scler"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0072","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.26662","article-title":"Comparative validation of automated presurgical tractography based on constrained spherical deconvolution and diffusion tensor imaging with direct electrical stimulation","volume":"45","author":"Radwan","year":"2024","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0073","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejca.2023.02.029","article-title":"Association between objective neurocognitive functioning and neurocognitive complaints in recurrent high-grade glioma: Longitudinal evidence of cognitive awareness from EORTC brain tumour trials","volume":"186","author":"Caramanna","year":"2023","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0074","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1109\/TMI.2009.2037915","article-title":"Optimal experimental design for diffusion kurtosis imaging","volume":"29","author":"Poot","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0075","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/nbm.3017","article-title":"Determination of the appropriate b value and number of gradient directions for high-angular-resolution diffusion-weighted imaging","volume":"26","author":"Tournier","year":"2013","journal-title":"NMR Biomed"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117731","article-title":"Virtual brain grafting: Enabling whole brain parcellation in the presence of large lesions","volume":"229","author":"Radwan","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0077","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMoa2304194","article-title":"Vorasidenib in IDH1- or IDH2-mutant low-grade glioma","volume":"389","author":"Mellinghoff","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.03.019_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103073","article-title":"Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation \u201c\u00e0 la carte\u201d","volume":"154","author":"Duffau","year":"2020","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:51:09Z","timestamp":1762296669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625002494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0360301625002494"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.019","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural Network Hubs as Potential Organs at Risk in Glioma Patients After Radiation Therapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}