{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:09:55Z","timestamp":1792681795590,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["24PRE1240097"],"award-info":[{"award-number":["24PRE1240097"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210099"],"award-info":[{"award-number":["RP210099"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["RP180770"],"award-info":[{"award-number":["RP180770"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR003163"],"award-info":[{"award-number":["UL1 TR003163"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ijrobp.2025.03.029","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T07:23:50Z","timestamp":1743578630000},"page":"306-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Principal Strain Analysis for Early Detection of Radiation-Induced Cardiotoxicity in a Mouse Model"],"prefix":"10.1016","volume":"123","author":[{"given":"Tanmay","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandhini","family":"Manikandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor-Jade","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-2829","authenticated-orcid":false,"given":"Steven K.","family":"Montalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaka","family":"Wansapura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Avazmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-9525","authenticated-orcid":false,"given":"Prasanna G.","family":"Alluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.03.029_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0002","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc3007","article-title":"Strategies to improve radiotherapy with targeted drugs","volume":"11","author":"Begg","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0003","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41698-017-0034-x","article-title":"Precision cardio-oncology: Understanding the cardiotoxicity of cancer therapy","volume":"1","author":"Han","year":"2017","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0005","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.echo.2014.07.012","article-title":"Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: A report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"27","author":"Plana","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0006","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13014-019-1408-8","article-title":"Early detection of subclinical left ventricular dysfunction after breast cancer radiation therapy using speckle-tracking echocardiography: Association between cardiac exposure and longitudinal strain reduction (BACCARAT study)","volume":"14","author":"Walker","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0007","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/ejhf.154","article-title":"Prevalence and prognostic value of subclinical left ventricular systolic dysfunction by global longitudinal strain in a community-based cohort","volume":"16","author":"Russo","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10334-004-0051-y","article-title":"Quantitative assessment of regional myocardial function in a rat model of myocardial infarction using tagged MRI","volume":"17","author":"Thomas","year":"2004","journal-title":"MAGMA"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0009","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/ehjci\/jez041","article-title":"Myocardial strain imaging: Review of general principles, validation, and sources of discrepancies","volume":"20","author":"Amzulescu","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jjcc.2020.11.004","article-title":"Segmental longitudinal strain as the most accurate predictor of the patchy pattern late gadolinium enhancement in hypertrophic cardiomyopathy","volume":"77","author":"Wabich","year":"2021","journal-title":"J Cardiol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0011","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.athoracsur.2014.10.067","article-title":"Regional myocardial three-dimensional principal strains during postinfarction remodeling","volume":"99","author":"Pilla","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0012","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/jcm12030743","article-title":"Clinical utility of strain imaging in assessment of myocardial fibrosis","volume":"12","author":"Gao","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0013","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaccao.2020.12.006","article-title":"Cardiac magnetic resonance for early detection of radiation therapy-induced cardiotoxicity in a small animal model","volume":"3","author":"Ibrahim","year":"2021","journal-title":"JACC. Cardio Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110113","article-title":"Dose-dependent changes in cardiac function, strain and remodelling in a preclinical model of heart base irradiation","volume":"193","author":"Ghita-Pettigrew","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0015","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCIMAGING.112.979385","article-title":"Three-dimensional reconstruction of the functional strain-line pattern in the left ventricle from 3-dimensional echocardiography","volume":"5","author":"Mangual","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0016","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.echo.2014.05.014","article-title":"Three-dimensional principal strain analysis for characterizing subclinical changes in left ventricular function","volume":"27","author":"Pedrizzetti","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0017","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-bioeng-062117-121129","article-title":"A contemporary look at biomechanical models of myocardium","volume":"21","author":"Avazmohammadi","year":"2019","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.887705","article-title":"Radiotherapy-induced cardiotoxicity: the role of multimodality cardiovascular imaging","volume":"9","author":"Podlesnikar","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0019","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.mrrev.2016.07.003","article-title":"Effects of ionizing radiation on the heart","volume":"770","author":"Boerma","year":"2016","journal-title":"Mutat Res Rev Mutat Res"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2342-10-1","article-title":"Design and validation of Segment \u2013 freely available software for cardiovascular image analysis","volume":"10","author":"Heiberg","year":"2010","journal-title":"BMC Med Imaging"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0021","doi-asserted-by":"crossref","unstructured":"Mukherjee T, Keshavarzian M, Fugate EM, et al. Complete spatiotemporal quantification of cardiac motion in mice through enhanced acquisition and super-resolution reconstruction. Preprint. Posted online June 3, 2024. bioRxiv 596322. doi:10.1101\/2024.05.31.596322","DOI":"10.1101\/2024.05.31.596322"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0022","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-3-030-78710-3_27","article-title":"An image registration framework to estimate 3D myocardial strains from cine cardiac MRI in mice","volume":"12738","author":"Keshavarzian","year":"2021","journal-title":"Funct Imaging Model Heart"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0023","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s10439-022-03102-z","article-title":"Contractile adaptation of the left ventricle post-myocardial infarction: Predictions by rodent-specific computational modeling","volume":"51","author":"Mendiola","year":"2023","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0024","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.radonc.2020.07.016","article-title":"Cardiac sub-volume targeting demonstrates regional radiosensitivity in the mouse heart","volume":"152","author":"Ghita","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0025","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1158\/1078-0432.CCR-20-3882","article-title":"A novel mouse model of radiation-induced cardiac injury reveals biological and radiological biomarkers of cardiac dysfunction with potential clinical relevance","volume":"27","author":"Dreyfuss","year":"2021","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.03.029_bib0026","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1532-429X-14-49","article-title":"Evaluation of left ventricular torsion by cardiovascular magnetic resonance","volume":"14","author":"Young","year":"2012","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625002561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:39:44Z","timestamp":1777955984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625002561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0360301625002561"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.029","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Principal Strain Analysis for Early Detection of Radiation-Induced Cardiotoxicity in a Mouse Model","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}