{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:13:51Z","timestamp":1783145631709,"version":"3.54.6"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ijrobp.2025.06.3294","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T10:07:54Z","timestamp":1749982074000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac Outcomes Following Adjuvant Radiation Therapy in Triple-Negative Breast Cancer Patients With Prior Autoimmune Myocarditis"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-8110","authenticated-orcid":false,"given":"Pierre","family":"Loap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assile","family":"El Fakih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Helal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Cabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fourquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toulsie","family":"Ramtohul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Loirat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Pierga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Cl\u00e9ment","family":"Bidard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Mirabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlia","family":"Kirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2020.103121","article-title":"Cardiotoxicity in breast cancer patients treated with radiation therapy: From evidences to controversies","volume":"156","author":"Loap","year":"2020","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0002","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.jacc.2018.02.037","article-title":"Myocarditis in patients treated with immune checkpoint inhibitors","volume":"71","author":"Mahmood","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0003","doi-asserted-by":"crossref","first-page":"810\u2011821","DOI":"10.1056\/NEJMoa1910549","article-title":"Pembrolizumab for early triple-negative breast cancer","volume":"382","author":"Schmid","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0004","doi-asserted-by":"crossref","first-page":"1749\u20111755","DOI":"10.1056\/NEJMoa1609214","article-title":"Fulminant myocarditis with combination immune checkpoint blockade","volume":"375","author":"Johnson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0005","doi-asserted-by":"crossref","first-page":"1579\u20111589","DOI":"10.1016\/S1470-2045(18)30608-9","article-title":"Cardiovascular toxicities associated with immune checkpoint inhibitors: An observational, retrospective, pharmacovigilance study","volume":"19","author":"Salem","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0006","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1001\/jamaoncol.2018.3923","article-title":"Fatal toxic effects associated with immune checkpoint inhibitors: A systematic review and meta-analysis","volume":"4","author":"Wang","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0007","doi-asserted-by":"crossref","first-page":"150\u2011158","DOI":"10.1080\/0284186X.2023.2177976","article-title":"Dosimetric evaluation of the benefit of deep inspiration breath hold (DIBH) for locoregional irradiation of right breast cancer with volumetric modulated arctherapy (VMAT)","volume":"62","author":"Loap","year":"2023","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0008","doi-asserted-by":"crossref","first-page":"13\u201120","DOI":"10.1016\/j.canrad.2020.05.016","article-title":"Evaluating cardiac substructure radiation exposure in breast rotational intensity modulated radiation therapy: Effects of cancer laterality, fractionation and deep inspiration breath-hold","volume":"25","author":"Loap","year":"2021","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0009","doi-asserted-by":"crossref","first-page":"335\u2011336","DOI":"10.5301\/tj.5000516","article-title":"Low-dose bath with volumetric modulated arc therapy in breast cancer: \u201cMuch ado about nothing?","volume":"102","author":"Alongi","year":"2016","journal-title":"Tumori"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0010","doi-asserted-by":"crossref","first-page":"108\u2011133","DOI":"10.1158\/2159-8290.CD-21-0003","article-title":"Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy","volume":"12","author":"Herrera","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0011","doi-asserted-by":"crossref","first-page":"835\u2011857","DOI":"10.1007\/s40262-019-00748-2","article-title":"Clinical pharmacokinetics and pharmacodynamics of immune checkpoint inhibitors","volume":"58","author":"Centanni","year":"2019","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0012","doi-asserted-by":"crossref","first-page":"469\u2011470","DOI":"10.1016\/j.ijrobp.2022.12.058","article-title":"In regard to Alcorn","volume":"116","author":"Loap","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0013","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031454","article-title":"Diagnostic approach for suspected acute myocarditis: Considerations for standardization and broadening clinical spectrum","volume":"12","author":"Martens","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0014","doi-asserted-by":"crossref","first-page":"214\u2011219","DOI":"10.1016\/j.radonc.2017.07.001","article-title":"Whole breast radiotherapy in the lateral isocentric lateral decubitus position: Long-term efficacy and toxicity results","volume":"124","author":"Bronsart","year":"2017","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0015","doi-asserted-by":"crossref","first-page":"1714\u20111768","DOI":"10.1200\/JCO.2017.77.6385","article-title":"Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice Guideline","volume":"36","author":"Brahmer","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0016","article-title":"Real-world safety and effectiveness of neoadjuvant chemotherapy combination with pembrolizumab in triple-negative breast cancer","volume":"5","author":"Rached","year":"2024","journal-title":"ESMO Real World Data Digit Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0017","article-title":"Recurrent myocarditis induced by immune-checkpoint inhibitor treatment is accompanied by persistent inflammatory markers despite immunosuppressive treatment","volume":"5","author":"Aghel","year":"2021","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0018","article-title":"Tolerance of concurrent adjuvant radiation therapy and pembrolizumab for triple negative breast cancer: Real life experience","volume":"9","author":"Tison","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0019","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.canrad.2021.01.005","article-title":"Clinical practice of breast cancer protontherapy: A single-centre experience from selection to treatment","volume":"25","author":"Loap","year":"2021","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0020","first-page":"59\u201164","article-title":"Radiation exposure of cardiac conduction nodes during breast proton therapy","volume":"10","author":"Loap","year":"2023","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0021","doi-asserted-by":"crossref","first-page":"417\u2011425","DOI":"10.1016\/j.ijrobp.2021.08.039","article-title":"Cardiac magnetic resonance imaging and blood biomarkers for evaluation of radiation-induced cardiotoxicity in patients with breast cancer: Results of a phase 2 clinical trial","volume":"112","author":"Speers","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3294_bib0022","doi-asserted-by":"crossref","first-page":"125\u2011134","DOI":"10.1016\/j.ijrobp.2022.01.020","article-title":"Is radiation-induced cardiac toxicity reversible? Prospective evaluation of patients with breast cancer enrolled in a phase 3 randomized controlled trial","volume":"113","author":"Abraham","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625039094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625039094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:44:15Z","timestamp":1762019055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625039094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0360301625039094"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.06.3294","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Outcomes Following Adjuvant Radiation Therapy in Triple-Negative Breast Cancer Patients With Prior Autoimmune Myocarditis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.06.3294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}