{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:51:05Z","timestamp":1792813865229,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006058","name":"Saint Baldricks Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ijrobp.2025.06.3876","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T02:40:57Z","timestamp":1751424057000},"page":"972-979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Contemporary Radiation Therapy Approaches in Combined Modality Treatment on Pediatric High-Risk Classic Hodgkin Lymphoma Study: AHOD 1331"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2312-5418","authenticated-orcid":false,"given":"Bradford S.","family":"Hoppe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond B.","family":"Mailhot-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglin","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Charpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul R.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan D.","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Alzaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"McCarten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Flampouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Kessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Y.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0001","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ijrobp.2016.01.053","article-title":"A comparative evaluation of normal tissue doses for patients receiving radiation therapy for Hodgkin lymphoma on the childhood cancer survivor study and recent Children\u2019s Oncology Group trials","volume":"95","author":"Zhou","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0002","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1182\/blood-2010-04-278796","article-title":"Morbidity and mortality in long-term survivors of Hodgkin lymphoma: A report from the childhood cancer survivor study","volume":"117","author":"Castellino","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ijrobp.2021.07.1716","article-title":"Radiation therapy across pediatric Hodgkin lymphoma research group protocols: A report from the staging, evaluation, and response criteria harmonization (SEARCH) for childhood, adolescent, and young adult Hodgkin lymphoma (CAYAHL) group","volume":"112","author":"Hall","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0004","doi-asserted-by":"crossref","first-page":"e951","DOI":"10.1016\/S2352-3026(24)00276-X","article-title":"Radiation target nomenclature for lymphoma trials: Consensus recommendations from the National Clinical Trials Network groups","volume":"11","author":"Saifi","year":"2024","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0005","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1200\/JCO.22.02320","article-title":"Cardiac substructure radiation dose and risk of late cardiac disease in survivors of childhood cancer: A report from the childhood cancer survivor study","volume":"41","author":"Bates","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0006","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ijrobp.2015.11.046","article-title":"Radiation-related new primary solid cancers in the childhood cancer survivor study: Comparative radiation dose response and modification of treatment effects","volume":"94","author":"Inskip","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0007","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1182\/blood-2008-10-184143","article-title":"A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: The results of P9425","volume":"114","author":"Schwartz","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0008","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ijrobp.2017.05.004","article-title":"Evidence-based review on the use of proton therapy in lymphoma from the Particle Therapy Cooperative Group (PTCOG) Lymphoma Subcommittee","volume":"99","author":"Tseng","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0009","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2022.10.003","article-title":"Systematic review for deep inspiration breath hold in proton therapy for mediastinal lymphoma: A PTCOG lymphoma subcommittee report and recommendations","volume":"177","author":"Patel","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0010","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1200\/JCO.20.03286","article-title":"Excellent outcome for pediatric patients with high-risk Hodgkin lymphoma treated with brentuximab vedotin and risk-adapted residual node radiation","volume":"39","author":"Metzger","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0011","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.prro.2019.09.015","article-title":"The meaningless meaning of mean heart dose in mediastinal lymphoma in the modern radiation therapy era","volume":"10","author":"Hoppe","year":"2020","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0012","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/annonc\/mdt156","article-title":"Estimated risk of cardiovascular disease and secondary cancers with modern highly conformal radiotherapy for early-stage mediastinal Hodgkin lymphoma","volume":"24","author":"Maraldo","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0013","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijrobp.2015.09.043","article-title":"In the battle between protons and photons for hematologic malignancies, the patient must win","volume":"95","author":"Dabaja","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0014","doi-asserted-by":"crossref","first-page":"21","DOI":"10.14338\/IJPT-21-00011.1","article-title":"Comparative effectiveness of proton therapy versus photon radiotherapy in adolescents and young adults for classical Hodgkin lymphoma","volume":"8","author":"Bates","year":"2022","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0015","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ijrobp.2020.08.055","article-title":"Risk of pneumonitis and outcomes after mediastinal proton therapy for relapsed\/refractory lymphoma: A PTCOG and PCG collaboration","volume":"109","author":"Tseng","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0016","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/annonc\/mdx287","article-title":"Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma","volume":"28","author":"Hoppe","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0017","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.radonc.2015.10.022","article-title":"Association of intensity-modulated radiation therapy on overall survival for patients with Hodgkin lymphoma","volume":"118","author":"Parikh","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0018","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJMoa2206660","article-title":"Brentuximab vedotin with chemotherapy in pediatric high-risk Hodgkin\u2019s lymphoma","volume":"387","author":"Castellino","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0019","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.prro.2014.05.003","article-title":"Implementation of contemporary radiation therapy planning concepts for pediatric Hodgkin lymphoma: Guidelines from the International Lymphoma Radiation Oncology Group","volume":"5","author":"Hodgson","year":"2015","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1200\/JCO.2015.63.4444","article-title":"Radiation dose-response relationship for risk of coronary heart disease in survivors of Hodgkin lymphoma","volume":"34","author":"van Nimwegen","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0021","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijrobp.2021.07.1711","article-title":"Establishing cost-effective allocation of proton therapy for patients with mediastinal Hodgkin lymphoma","volume":"112","author":"Mailhot Vega","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0022","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.ijrobp.2014.04.029","article-title":"Involved-node proton therapy in combined modality therapy for Hodgkin lymphoma: Results of a phase 2 study","volume":"89","author":"Hoppe","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.31290","article-title":"Outcomes of proton therapy to infradiaphragmatic sites in pediatric patients with Hodgkin lymphoma","volume":"71","author":"Jiang","year":"2024","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0024","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.radonc.2022.01.016","article-title":"Vital organ sparing with proton therapy for pediatric Hodgkin lymphoma: Toxicity and outcomes in 50 patients","volume":"168","author":"Tringale","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0025","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1002\/cncr.32938","article-title":"Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy","volume":"126","author":"Xiang","year":"2020","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0026","article-title":"Insurance coverage decisions for pediatric proton therapy","volume":"65","author":"Ojerholm","year":"2018","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0027","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijrobp.2010.05.007","article-title":"Rationale for and preliminary results of proton beam therapy for mediastinal lymphoma","volume":"81","author":"Li","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0028","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.3109\/10428194.2010.493250","article-title":"Cardiac sparing with proton therapy in consolidative radiation therapy for Hodgkin lymphoma","volume":"51","author":"Hoppe","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0029","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S1470-2045(05)70248-5","article-title":"Proton radiotherapy for Hodgkin\u2019s disease in the sacrum","volume":"6","author":"Kirsch","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14338\/IJPT-21-00012.1","article-title":"Evaluating disparities in proton radiation therapy use in AHOD1331, a contemporary Children\u2019s Oncology Group trial for advanced-stage Hodgkin lymphoma","volume":"8","author":"Mailhot Vega","year":"2022","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.ijrobp.2025.06.3876_bib0031","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/jnci\/djae013","article-title":"Accelerating pediatric Hodgkin lymphoma research: The Hodgkin Lymphoma Data Collaboration (NODAL)","volume":"116","author":"Wyatt","year":"2024","journal-title":"J Natl Cancer Inst"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625045183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625045183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:30:00Z","timestamp":1760826600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625045183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0360301625045183"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.06.3876","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Contemporary Radiation Therapy Approaches in Combined Modality Treatment on Pediatric High-Risk Classic Hodgkin Lymphoma Study: AHOD 1331","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.06.3876","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}