{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:39Z","timestamp":1791654639868,"version":"4.3.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ijrobp.2025.07.1447","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:05:43Z","timestamp":1754492743000},"page":"133-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["HYPofractionated Adjuvant RadioTherapy in 1 Versus 2 Weeks in High-Risk Patients With Breast Cancer (HYPART): Acute Toxicity Results"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-4139","authenticated-orcid":false,"given":"Budhi Singh","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Vias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avradeep","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali","family":"Kataria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngangom Robert","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Laroiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh","family":"Irrinki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"P","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0001","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S1470-2045(13)70386-3","article-title":"The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials","volume":"14","author":"Haviland","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0002","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S1460396909990124","article-title":"Therapeutic benefit of radiotherapy after surgery in patients with T1-T2 breast tumour","volume":"9","author":"Yadav","year":"2010","journal-title":"J Radiother Pract"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0003","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term results of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.ijrobp.2025.07.1447_bib0004","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/0973-1482.136560","article-title":"Post-mastectomy radiation beyond chest wall in patients with N1 breast cancer: is there a benefit?","volume":"10","author":"Yadav","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1470-2045(18)30813-1","article-title":"Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: A randomised, non-inferiority, open-label, phase 3 trial","volume":"20","author":"Wang","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0006","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1200\/JCO.20.01024","article-title":"Hypofractionated versus conventional fractionated radiotherapy after breast-conserving surgery in the modern treatment era: A multicenter, randomized controlled trial from China","volume":"38","author":"Wang","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0007","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2016.02.027","article-title":"Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial","volume":"120","author":"Brunt","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.adro.2019.09.005","article-title":"Comparison of toxicity and cosmetic outcomes after accelerated partial breast irradiation or whole breast irradiation using 3-dimensional conformal external beam radiation therapy","volume":"5","author":"Yadav","year":"2020","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0009","article-title":"Preliminary results of hypofractionated radiotherapy in breast cancer in Chandigarh, India: Single-centre, non-inferiority, open-label, randomised, phase 3 trial","volume":"24","author":"Yadav","year":"2024","journal-title":"Lancet Reg Health Southeast Asia"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0010","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000543855","article-title":"Three-fraction external beam radiotherapy in patients with early breast cancer","volume":"20","author":"Yadav","year":"2025","journal-title":"Breast Care (Basel)"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0011","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Murray Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0012","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/0973-1482.136560","article-title":"Post-mastectomy radiation beyond chest wall in patients with N1 breast cancer: Is there a benefit?","volume":"10","author":"Yadav","year":"2014","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0013","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13063-023-07851-7","article-title":"Hypofractionated Adjuvant RadioTherapy in 1 versus 2 weeks in high-risk patients with breast cancer (HYPART): A non-inferiority, open-label, phase III randomised trial","volume":"25","author":"Yadav","year":"2024","journal-title":"Trials"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0014","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ijrobp.2017.12.015","article-title":"A phase 2 study of 2 weeks of adjuvant whole breast\/chest wall and\/or regional nodal radiation therapy for patients with breast cancer","volume":"100","author":"Yadav","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.radonc.2022.07.003","article-title":"Hyport Adjuvant AuthorGroup. HYPORT adjuvant acute toxicity and patient dosimetry quality assurance results \u2013 Interim analysis","volume":"174","author":"Chakraborty","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3857\/roj.2021.01053","article-title":"Accelerated hypofractionated breast radiotherapy with simultaneous integrated boost: A feasibility study","volume":"40","author":"Yadav","year":"2022","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0017","article-title":"Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results","volume":"46","author":"Ratosa","year":"2024","journal-title":"Clin Transl Radiat Oncol"},{"issue":"5_suppl","key":"10.1016\/j.ijrobp.2025.07.1447_bib0018","first-page":"GS5","article-title":"Abstract GS5-12: Hypofractionated Radiotherapy in patients with Breast Cancer (HRBC): Acute toxicity data of a phase III randomized study","volume":"83","author":"Yadav","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0019","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1200\/JCO.20.00459","article-title":"Quantifying the impact of axillary surgery and nodal irradiation on breast cancer-related lymphedema and local tumor control: Long-term results from a prospective screening trial","volume":"38","author":"Naoum","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0020","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clbc.2024.03.007","article-title":"Hypofractionation for regional nodal irradiation in breast cancer: Best of both the worlds","volume":"24","author":"Yadav","year":"2024","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0021","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijrobp.2023.04.020","article-title":"Regional lymph node radiation is not the main risk factor for breast cancer related lymphedema: Stop chasing radiation doses, fractionation or techniques-focus on axillary surgery de-escalation or prevention","volume":"117","author":"Naoum","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0022","first-page":"S4430","article-title":"DBCG Skagen trial 1: Phase III randomised trial of hypo- vs standard fractionated loco-regional radiotherapy in node-positive breast cancer patients","volume":"5027","author":"Offerson","year":"2025","journal-title":"ESTRO"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0023","first-page":"503","article-title":"Breast cancer hypofractionated radiotherapy in 2-weeks with 2D technique: 5-year clinical outcomes of a phase 2 trial","volume":"26","author":"Yadav","year":"2021","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.ijrobp.2025.07.1447_bib0024","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3857\/roj.2020.00129","article-title":"Late-term effects of hypofractionated chest wall and regional nodal radiotherapy with two-dimensional technique in patients with breast cancer","volume":"38","author":"Yadav","year":"2020","journal-title":"Radiat Oncol J"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625060456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625060456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:47:31Z","timestamp":1791654451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625060456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0360301625060456"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.07.1447","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HYPofractionated Adjuvant RadioTherapy in 1 Versus 2 Weeks in High-Risk Patients With Breast Cancer (HYPART): Acute Toxicity Results","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.07.1447","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}