{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:00:56Z","timestamp":1784854856424,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009530","name":"Jawaharlal Institute of Postgraduate Medical Education and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020407","name":"Tata Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ijrobp.2025.10.035","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:01:42Z","timestamp":1762192902000},"page":"952-960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Low-Cost Polyurethane Film in Reducing Dermatitis Severity in Breast Cancer Patients With Higher Fitzpatrick Skin Types Undergoing Hypofractionated Irradiation With Simultaneous Integrated Boost: An Intrapatient Randomized Controlled Trial"],"prefix":"10.1016","volume":"124","author":[{"given":"Madhubalan","family":"Harish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-1734","authenticated-orcid":false,"given":"Karunanithi","family":"Gunaseelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda Kishore","family":"Maroju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinnatamby","family":"Mourougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manivannan","family":"Mananvalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadass","family":"Parmeshwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premkumar","family":"Ramasubramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.10.035_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.753209","article-title":"Comparing hypofractionated with conventional fractionated radiotherapy after breast-conserving surgery for early breast cancer: A meta-analysis of randomized controlled trials","volume":"11","author":"Gu","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0002","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annonc.2023.11.016","article-title":"Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"35","author":"Loibl","year":"2024","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0003","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijwd.2020.07.015","article-title":"Dermatologic toxicities associated with radiation therapy in women with breast cancer","volume":"6","author":"Ramseier","year":"2020","journal-title":"Int J Womens Dermatol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30710-4","article-title":"Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: Objective, longitudinal assessment of skin color","volume":"8","author":"Yamazaki","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/0284186X.2018.1441542","article-title":"Prophylactically applied Hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients","volume":"57","author":"Schmeel","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0006","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/polym11122112","article-title":"Hydrofilm polyurethane films reduce radiation dermatitis severity in hypofractionated whole-breast irradiation: An objective, intra-patient randomized dual-center assessment","volume":"11","author":"Schmeel","year":"2019","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0007","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1200\/JCO.22.01873","article-title":"Mepitel film for the prevention of acute radiation dermatitis in breast cancer: A randomized multicenter open-label phase III trial","volume":"41","author":"Behroozian","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0008","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2014.01.005","article-title":"Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients","volume":"110","author":"Herst","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0009","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tipsro.2018.05.004","article-title":"Breast cancer patients report reduced sensitivity and pain using a barrier film during radiotherapy - A Danish intra-patient randomized multicentre study","volume":"7","author":"M\u00f8ller","year":"2018","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.breast.2019.05.012","article-title":"Mepitel Film and Mepilex Lite for the prophylaxis and treatment of skin toxicities from breast radiation","volume":"46","author":"Wan","year":"2019","journal-title":"Breast"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0011","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jmir.2014.03.050","article-title":"Phase III randomized pair comparison of a barrier film vs. standard skin care in preventing radiation dermatitis in women with breast cancer receiving adjuvant radiation therapy","volume":"45","author":"Rempel","year":"2014","journal-title":"J Med Imaging Radiat Sci"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0012","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1470-2045(08)70077-9","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"9","author":"Trialists\u2019 Group","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0013","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"371","author":"Trialists\u2019 Group","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0014","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1200\/JCO.19.02750","article-title":"Ten-year results of FAST: A randomized controlled Trial of 5-fraction whole-breast radiotherapy for early breast cancer","volume":"38","author":"Brunt","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0015","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial","volume":"395","author":"Brunt","year":"2020","journal-title":"The Lancet"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0016","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1186\/s13063-020-04751-y","volume":"21","author":"Chatterjee","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0017","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ijrobp.2022.07.2320","article-title":"NRG RTOG 1005: A phase III trial of hypo fractionated whole breast irradiation with concurrent boost vs. conventional whole breast irradiation plus sequential boost following lumpectomy for high risk early-stage breast cancer","volume":"114","author":"Vicini","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0018","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1748-717X-7-145","article-title":"Phase I-II study of hypofractionated simultaneous integrated boost using volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer patients: A report of feasibility and early toxicity results in the first 50 treatments","volume":"7","author":"Scorsetti","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0019","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1016\/S1470-2045(23)00067-0","article-title":"Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: International Delphi consensus-based recommendations","volume":"24","author":"Behroozian","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0020","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.breast.2023.07.001","article-title":"Barrier films for the prevention of acute radiation dermatitis in breast cancer: A systematic review and meta-analysis of randomised controlled trials","volume":"71","author":"Dejonckheere","year":"2023","journal-title":"Breast"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0021","first-page":"313","article-title":"Acute radiation dermatitis in breast cancer patients: Challenges and solutions","volume":"9","author":"Kole","year":"2017","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0022","article-title":"Delphi consensus-based recommendations of tools and outcomes for the assessment of radiation dermatitis severity","volume":"206","author":"Rahman","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.10.035_bib0023","article-title":"Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity","volume":"53","author":"Patel","year":"2025","journal-title":"Clin Transl Radiat Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625064223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625064223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:02:32Z","timestamp":1784851352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625064223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0360301625064223"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.10.035","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of Low-Cost Polyurethane Film in Reducing Dermatitis Severity in Breast Cancer Patients With Higher Fitzpatrick Skin Types Undergoing Hypofractionated Irradiation With Simultaneous Integrated Boost: An Intrapatient Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.10.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}