{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:09:18Z","timestamp":1780391358947,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ijrobp.2025.11.039","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:34:50Z","timestamp":1764390890000},"page":"444-453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Five-Year Outcomes of Moderately Hypofractionated Whole Pelvic Radiation Therapy with Concurrent Chemotherapy and Image Guided High Dose Rate Brachytherapy for Locally Advanced Cervical Carcinoma"],"prefix":"10.1016","volume":"125","author":[{"given":"Ajeet Kumar","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhup","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahat","family":"Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Kumar","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vachaspati Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakhi","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tenzing Dahla","family":"Bhutia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Ramola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Burman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin Kumar","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradyumn","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.11.039_bib0001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0002","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4103\/ijmr.ijmr_1821_22","article-title":"Cancer incidence estimates for 2022 & projection for 2025: Result from National Cancer Registry Programme, India","volume":"156","author":"Sathishkumar","year":"2022","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0003","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/ijgc-2021-003001","article-title":"Global challenges of radiotherapy for the treatment of locally advanced cervical cancer","volume":"32","author":"Mayadev","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0004","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ijrobp.2013.06.2059","article-title":"Early clinical outcomes and toxicity of intensity modulated versus conventional pelvic radiation therapy for locally advanced cervix carcinoma: A prospective randomized study","volume":"87","author":"Gandhi","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5114\/jcb.2023.132553","article-title":"Combination of image-guided IMRT and IGBT in locally advanced carcinoma cervix: Prospective evaluation of toxicities and clinical outcomes from a tertiary cancer center in India","volume":"15","author":"Mishra","year":"2023","journal-title":"J Contemp Brachytherapy"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0006","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/cncr.27652","article-title":"The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy","volume":"119","author":"Song","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0007","article-title":"Challenges and opportunities with the use of hypofractionated radiation therapy in cancer care: Regional perspectives from South Korea, Japan, Singapore, and Australia","volume":"8","author":"Akimoto","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0008","first-page":"48","article-title":"The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies","volume":"9","author":"P\u00f6tter","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0009","first-page":"253","article-title":"Comparative evaluation of hypofractionated radiotherapy and conventional fractionated radiotherapy in the management of carcinoma of the cervix in Ibadan, Nigeria","volume":"29","author":"Campbell","year":"2000","journal-title":"Afr J Med Med Sci"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0010","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.ijrobp.2004.04.053","article-title":"Concurrent chemotherapy and hypofractionated twice-daily radiotherapy in cervical cancer patients with stage IIIB disease and bilateral parametrial involvement: A phase I-II study","volume":"60","author":"Viegas","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0011","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00432-023-05563-8","article-title":"Hypofractionated versus standard chemoradiotherapy in the definitive treatment of uterine cervix cancer: Interim results of a randomized controlled clinical trial","volume":"150","author":"Maddah Safaei","year":"2024","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1552346","article-title":"A comparative analysis of hypofractionated versus conventional radiotherapy for cervical cancer in a resource-limited setting: A prospective study","volume":"15","author":"Mallum","year":"2025","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0013","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2020.05.032","article-title":"Should we embrace hypofractionated radiotherapy for cervical cancer? A technical note on management during the COVID-19 pandemic","volume":"148","author":"Mendez","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0014","first-page":"127","article-title":"Hypofractionated radiotherapy in carcinoma cervix IIIB: Tata Memorial Hospital experience","volume":"39","author":"Muckaden","year":"2002","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0015","doi-asserted-by":"crossref","first-page":"e365","DOI":"10.1016\/j.clon.2024.06.032","article-title":"Clinical outcomes of hypo-fractionated radiotherapy and intercalated brachytherapy in cervical carcinoma: A prospective clinical study","volume":"36","author":"Ananth","year":"2024","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0016","doi-asserted-by":"crossref","first-page":"207","DOI":"10.21037\/atm.2017.03.102","article-title":"External beam techniques to boost cervical cancer when brachytherapy is not an option-theories and applications","volume":"5","author":"Mahmoud","year":"2017","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0017","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1016\/j.ijrobp.2019.06.130","article-title":"Hypo-fractionation in muscle-invasive bladder cancer: An individual patient data (IPD) meta-analysis of the BC2001 and BCON trials","volume":"105","author":"Porta","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 1","key":"10.1016\/j.ijrobp.2025.11.039_bib0018","doi-asserted-by":"crossref","first-page":"e695","DOI":"10.1016\/j.ijrobp.2024.07.1529","article-title":"Hypofractionated radiotherapy in treatment of cervical cancer: A systematic review","volume":"120","author":"Kibudde","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0019","series-title":"Hypofractionated External-beam RadiOtherapy for Intact Cervical Cancer (HEROICC-Trial): A feasibility study","year":"2023"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0020","series-title":"Moderately hypofractionated adaptive radiotherapy for cervical cancer","year":"2025"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0021","series-title":"Chemotherapy and pelvic hypofractionated radiation followed by surgery cervical cancer","year":"2023"},{"issue":"suppl","key":"10.1016\/j.ijrobp.2025.11.039_bib0022","first-page":"S129","article-title":"Prospective evaluation of acute toxicity with intensity-modulated moderately hypofractionated whole pelvic radiotherapy with image-guided brachytherapy for locally advanced cervical carcinoma","volume":"20","author":"Burman","year":"2024","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0023","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1136\/ijgc-2024-005419","article-title":"Efficacy of cumulative cisplatin dose on survival in patients with locally advanced cervical cancer treated with definitive chemoradiotherapy: Multicenter study by Turkish Oncology Group","volume":"34","author":"Akyildiz","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0024","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1080\/0284186X.2022.2048070","article-title":"Phase 1\/2 trial evaluating the effectiveness and safety of dose-adapted hypofractionated pelvic radiotherapy for Advanced Cervical cancers INeligible for ChemoTherapy (HYACINCT)","volume":"61","author":"Bacorro","year":"2022","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0025","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.ijrobp.2024.07.014","article-title":"Moderated hypofractionated online adaptive radiotherapy in locally advanced cervical cancer: A prospective 1 clinical trial","volume":"120","author":"Zeng","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0026","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1002\/cncr.28849","article-title":"Complications of pelvic radiation in patients treated for gynecologic malignancies","volume":"120","author":"Viswanathan","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0027","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ijrobp.2023.01.002","article-title":"Overall severe morbidity after chemo-radiation therapy and magnetic resonance imaging-guided adaptive brachytherapy in locally advanced cervical cancer: Results from the EMBRACE-I study","volume":"116","author":"Vittrup","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0028","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.radonc.2016.06.006","article-title":"Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study","volume":"120","author":"Mazeron","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0029","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): A multicentre prospective cohort study","volume":"22","author":"P\u00f6tter","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.radonc.2021.05.010","article-title":"IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer","volume":"160","author":"Mahantshetty","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0031","series-title":"Study of pelvic hypofractionated radiotherapy in endometrial cancer","year":"2025"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0032","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jamaoncol.2024.0565","article-title":"Postoperative hypofractionated intensity-modulated radiotherapy with concurrent chemotherapy in cervical cancer: The POHIM-CCRT nonrandomized controlled trial","volume":"10","author":"Cho","year":"2024","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2025.11.039_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamaoncol.2022.0362","article-title":"Quality-of-life outcomes and toxic effects among patients with cancers of the uterus treated with stereotactic pelvic adjuvant radiation therapy: The SPARTACUS phase 1\/2 nonrandomized controlled trial","volume":"8","author":"Leung","year":"2022","journal-title":"JAMA Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030162506523X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030162506523X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:20:28Z","timestamp":1780388428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030162506523X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S036030162506523X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.11.039","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Five-Year Outcomes of Moderately Hypofractionated Whole Pelvic Radiation Therapy with Concurrent Chemotherapy and Image Guided High Dose Rate Brachytherapy for Locally Advanced Cervical Carcinoma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.11.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}