{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:47:47Z","timestamp":1789141667358,"version":"build-2803163510"},"reference-count":78,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,6,24]],"date-time":"2027-06-24T00:00:00Z","timestamp":1813795200000},"content-version":"am","delay-in-days":358,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["P50CA278595"],"award-info":[{"award-number":["P50CA278595"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R37CA255330"],"award-info":[{"award-number":["R37CA255330"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R00CA160639"],"award-info":[{"award-number":["R00CA160639"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA256166"],"award-info":[{"award-number":["K08CA256166"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA284747"],"award-info":[{"award-number":["R01CA284747"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD023526"],"award-info":[{"award-number":["S10 OD023526"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000982","name":"Conquer Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005625","name":"RSNA Research and Educational Foundation","doi-asserted-by":"publisher","award":["RF1904"],"award-info":[{"award-number":["RF1904"]}],"id":[{"id":"10.13039\/100005625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","award":["P250255US01"],"award-info":[{"award-number":["P250255US01"]}],"id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007881","name":"Fondation pour la M\u00e9decine de Laboratoire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006098","name":"Radiological Society of North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["P50DE026787"],"award-info":[{"award-number":["P50DE026787"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ijrobp.2025.12.014","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:07:27Z","timestamp":1768972047000},"page":"1176-1189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers"],"prefix":"10.1016","volume":"125","author":[{"given":"Pippa F.","family":"Cosper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Paracha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hrycyniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Eyzaguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"McCunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Boulanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangok P.","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Horner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Harari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Kimple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2025.12.014_bib0001","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ccell.2018.03.007","article-title":"Genomic and functional approaches to understanding cancer aneuploidy","volume":"33","author":"Taylor","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0002","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ceb.2006.10.002","article-title":"Does aneuploidy cause cancer?","volume":"18","author":"Weaver","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0003","unstructured":"Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (2026). Mitelman F, Johansson B, and Mertens F (Eds)., https:\/\/mitelmandatabase.isb-cgc.org"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0004","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.semcdb.2013.02.001","article-title":"2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells","volume":"24","author":"Zasadil","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2006.10.019","article-title":"Mad2 overexpression promotes aneuploidy and tumorigenesis in mice","volume":"11","author":"Sotillo","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0006","doi-asserted-by":"crossref","first-page":"E2205","DOI":"10.1073\/pnas.1201911109","article-title":"Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons","volume":"109","author":"Ryan","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0007","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature08136","article-title":"A mechanism linking extra centrosomes to chromosomal instability","volume":"460","author":"Ganem","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0008","doi-asserted-by":"crossref","first-page":"e6564","DOI":"10.1371\/journal.pone.0006564","article-title":"Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells","volume":"4","author":"Silkworth","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0009","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature11935","article-title":"Replication stress links structural and numerical cancer chromosomal instability","volume":"494","author":"Burrell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0010","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1038\/ncomms6990","article-title":"Numerical chromosomal instability mediates susceptibility to radiation treatment","volume":"6","author":"Bakhoum","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0011","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/386623a0","article-title":"Genetic instability in colorectal cancers","volume":"386","author":"Lengauer","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0012","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.semradonc.2021.09.002","article-title":"Chromosome missegregation as a modulator of radiation sensitivity","volume":"32","author":"Cosper","year":"2022","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0013","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.molcel.2012.07.029","article-title":"Playing the end game: DNA double-strand break repair pathway choice","volume":"47","author":"Chapman","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0014","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1101\/gad.348319.121","article-title":"Transient genomic instability drives tumorigenesis through accelerated clonal evolution","volume":"35","author":"Shoshani","year":"2021","journal-title":"Genes Dev"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0015","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/j.devcel.2021.07.009","article-title":"Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies","volume":"56","author":"Lukow","year":"2021","journal-title":"Dev Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0016","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.devcel.2021.07.006","article-title":"Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy","volume":"56","author":"Ippolito","year":"2021","journal-title":"Dev Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0017","doi-asserted-by":"crossref","first-page":"eabd4811","DOI":"10.1126\/scitranslmed.abd4811","article-title":"Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel","volume":"13","author":"Scribano","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0018","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ccr.2009.10.023","article-title":"Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity","volume":"16","author":"Baker","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0019","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1158\/0008-5472.CAN-06-3326","article-title":"Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice","volume":"67","author":"Iwanaga","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0020","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/35053094","article-title":"MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells","volume":"409","author":"Michel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002339","article-title":"Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles","volume":"21","author":"Zhou","year":"2023","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0022","doi-asserted-by":"crossref","first-page":"19108","DOI":"10.1073\/pnas.0904343106","article-title":"Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells","volume":"106","author":"Janssen","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0023","doi-asserted-by":"crossref","first-page":"E4134","DOI":"10.1073\/pnas.1317042110","article-title":"Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors","volume":"110","author":"Silk","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0024","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1091\/mbc.E15-10-0747","article-title":"High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation","volume":"27","author":"Zasadil","year":"2016","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1158\/1541-7786.MCR-20-0488","article-title":"p53 is not required for high CIN to induce tumor suppression","volume":"19","author":"Funk","year":"2021","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0026","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1073\/pnas.0401142101","article-title":"Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint","volume":"101","author":"Kops","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0027","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/bs.mcb.2018.03.002","article-title":"Quantitative methods to measure aneuploidy and chromosomal instability","volume":"144","author":"Godek","year":"2018","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0028","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tig.2008.07.002","article-title":"Whole chromosome instability and cancer: A complex relationship","volume":"24","author":"Ricke","year":"2008","journal-title":"Trends Genet"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0029","article-title":"Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer","volume":"4","author":"Dhital","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0030","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.celrep.2016.05.048","article-title":"Negative selection and chromosome instability induced by Mad2 overexpression delay breast cancer but facilitate oncogene-independent outgrowth","volume":"15","author":"Rowald","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0031","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/annonc\/mdv178","article-title":"Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: A prospective validation cohort study from the TACT trial","volume":"26","author":"Jamal-Hanjani","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0032","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1158\/1055-9965.EPI-11-0343","article-title":"Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer","volume":"20","author":"Roylance","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0033","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0034","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","article-title":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers","volume":"92","author":"Gillison","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0035","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/0014-4827(63)90026-0","article-title":"Induction of multipolar spindles by X-radiation in mammalian cells in vitro","volume":"31","author":"Levis","year":"1963","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0036","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1083\/jcb.96.3.776","article-title":"Microtubule-organizing centers abnormal in number, structure, and nucleating activity in x-irradiated mammalian cells","volume":"96","author":"Sato","year":"1983","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0037","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1038\/sj.emboj.7600393","article-title":"Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM","volume":"23","author":"Dodson","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0038","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/excr.1999.4797","article-title":"Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells","volume":"255","author":"Sato","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0039","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1038\/sj.onc.1203902","article-title":"A possible role for centrosome overduplication in radiation-induced cell death","volume":"19","author":"Sato","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0040","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1038\/sj.onc.1208589","article-title":"Partial downregulation of MAD1 causes spindle checkpoint inactivation and aneuploidy, but does not confer resistance towards taxol","volume":"24","author":"Kienitz","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0041","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0042","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","article-title":"Analysis and visualization of longitudinal genomic and clinical data from the AACR project GENIE biopharma collaborative in cBioPortal","volume":"83","author":"de Bruijn","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0043","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0044","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2307\/3572025","article-title":"X-ray sensitivity during the cell generation cycle of cultured chinese hamster cells","volume":"29","author":"Sinclair","year":"1966","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0045","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1200\/JCO.22.00980","article-title":"Results of phase III randomized trial for use of docetaxel as a radiosensitizer in patients with head and neck cancer, unsuitable for cisplatin-based chemoradiation","volume":"41","author":"Patil","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0046","first-page":"5198","article-title":"Paclitaxel enhances in vitro radiosensitivity of squamous carcinoma cell lines of the head and neck","volume":"56","author":"Leonard","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0047","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jnci\/86.6.441","article-title":"In vitro studies of Taxol as a radiation sensitizer in human tumor cells","volume":"86","author":"Liebmann","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0048","first-page":"2431","article-title":"Docetaxel enhances tumor radioresponse in vivo","volume":"3","author":"Mason","year":"1997","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0049","doi-asserted-by":"crossref","first-page":"229ra43","DOI":"10.1126\/scitranslmed.3007965","article-title":"Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles","volume":"6","author":"Zasadil","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0050","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1158\/0008-5472.CAN-23-3332","article-title":"CENP-E inhibition induces chromosomal instability and synergizes with diverse microtubule-targeting agents in breast cancer","volume":"84","author":"Tucker","year":"2024","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0051","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.oraloncology.2016.11.017","article-title":"Defining the boundaries and expanding the utility of head and neck cancer patient derived xenografts","volume":"64","author":"Swick","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0052","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1186\/s12885-018-4890-8","article-title":"Human papillomavirus infection in patients with laryngeal carcinoma","volume":"18","author":"Onerci Celebi","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0053","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12105-013-0486-4","article-title":"Human papillomavirus-associated head and neck squamous cell carcinoma survival: A comparison by tumor site and initial treatment","volume":"8","author":"Salazar","year":"2014","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0054","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/bjc.2015.59","article-title":"Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma","volume":"112","author":"Young","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12885-016-2083-x","article-title":"Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer","volume":"16","author":"Denu","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0056","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2767-9764.CRC-22-0302","article-title":"Misaligned chromosomes are a major source of chromosomal instability in breast cancer","volume":"3","author":"Tucker","year":"2023","journal-title":"Cancer Res Commun"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0057","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309621121","article-title":"A survey of chromosomal instability measures across mechanistic models","volume":"121","author":"Lynch","year":"2024","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0058","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1200\/JCO.2013.53.9163","article-title":"Postoperative chemoradiotherapy and cetuximab for high-risk squamous cell carcinoma of the head and neck: Radiation Therapy Oncology Group RTOG-0234","volume":"32","author":"Harari","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0059","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1158\/0008-5472.CAN-15-1617","article-title":"Effects of anticancer drugs on chromosome instability and new clinical implications for tumor-suppressing therapies","volume":"76","author":"Lee","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216700120","article-title":"HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E","volume":"120","author":"Cosper","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0061","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1158\/0008-5472.CAN-13-0587","article-title":"Enhanced radiation sensitivity in HPV-positive head and neck cancer","volume":"73","author":"Kimple","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0062","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.radonc.2013.03.013","article-title":"HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity","volume":"107","author":"Rieckmann","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0063","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2009.10.008","article-title":"HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer","volume":"94","author":"Lassen","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0064","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/cncr.28656","article-title":"Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy","volume":"120","author":"Zaki","year":"2014","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113735","article-title":"Pre-existing subclones determine radioresistance in rectal cancer organoids","volume":"43","author":"Andel","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0066","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1172\/JCI59954","article-title":"Chromosomal instability and cancer: A complex relationship with therapeutic potential","volume":"122","author":"Bakhoum","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0067","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1172\/JCI130435","article-title":"TTK inhibition radiosensitizes basal-like breast cancer through impaired homologous recombination","volume":"130","author":"Chandler","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0068","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1083\/jcb.201001036","article-title":"Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine","volume":"190","author":"Santaguida","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0069","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1101\/gr.276378.121","article-title":"Extensive protein dosage compensation in aneuploid human cancers","volume":"32","author":"Schukken","year":"2022","journal-title":"Genome Res"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0070","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1101\/gad.207407.112","article-title":"Aneuploidy causes proteotoxic stress in yeast","volume":"26","author":"Oromendia","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0071","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.15252\/embj.201488648","article-title":"HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells","volume":"33","author":"Donnelly","year":"2014","journal-title":"EMBO J"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0072","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.1206412","article-title":"Aneuploidy drives genomic instability in yeast","volume":"333","author":"Sheltzer","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0073","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10754","article-title":"The presence of extra chromosomes leads to genomic instability","volume":"7","author":"Passerini","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0074","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/s41467-023-37095-7","article-title":"Short-term molecular consequences of chromosome mis-segregation for genome stability","volume":"14","author":"Garribba","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0075","doi-asserted-by":"crossref","first-page":"7772","DOI":"10.1038\/s41467-024-52176-x","article-title":"Human aneuploid cells depend on the RAF\/MEK\/ERK pathway for overcoming increased DNA damage","volume":"15","author":"Zerbib","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0076","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ijrobp.2022.12.015","article-title":"Long-Term update of NRG\/RTOG 0522: A randomized phase 3 trial of concurrent radiation and cisplatin with or without cetuximab in locoregionally advanced head and neck cancer","volume":"116","author":"Caudell","year":"2023","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0077","doi-asserted-by":"crossref","first-page":"20921","DOI":"10.18632\/oncotarget.4879","article-title":"Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy","volume":"6","author":"Bennett","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijrobp.2025.12.014_bib0078","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.200303167","article-title":"Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss","volume":"162","author":"Weaver","year":"2003","journal-title":"J. Cell Biol."}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625065915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301625065915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:14:43Z","timestamp":1782486883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301625065915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":78,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0360301625065915"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.12.014","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pretreatment Chromosomal Instability Correlates With Radiation Sensitivity in Squamous Cell Cancers","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2025.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}