{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:26:42Z","timestamp":1793608002654,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007052","name":"MEMORIAL SLOAN KETTERING CANCER CENTER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ijrobp.2026.04.001","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:49:47Z","timestamp":1776066587000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric Results for Organs at Risk From Radiation Therapy Dose De-Escalation to the Subclinical Region in Human Papillomavirus-Associated Oropharyngeal Cancer: A Propensity Score-Matched Analysis"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-6998","authenticated-orcid":false,"given":"David Gibbes","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irini","family":"Yacoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Aliotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kallini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Zakeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Julie","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achraf A.","family":"Shamseddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna Y.","family":"Gelblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Aristophanous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2026.04.001_bib0001","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0002","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.prro.2018.10.015","article-title":"Reducing the radiation therapy dose prescription for elective treatment areas in human papillomavirus\u2013associated oropharyngeal carcinoma being treated with primary chemoradiotherapy at Memorial Sloan Kettering Cancer Center","volume":"9","author":"Tsai","year":"2019","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0003","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/jamaoncol.2021.6416","article-title":"Evaluation of substantial reduction in elective radiotherapy dose and field in patients with human papillomavirus\u2013associated oropharyngeal carcinoma treated with definitive chemoradiotherapy","volume":"8","author":"Tsai","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0004","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.prro.2017.02.002","article-title":"Radiation therapy for oropharyngeal squamous cell carcinoma: Executive summary of an ASTRO Evidence-Based Clinical Practice Guideline","volume":"7","author":"Sher","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","article-title":"Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): A randomised, multicentre, non-inferiority trial","volume":"393","author":"Gillison","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0006","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.semradonc.2017.04.008","article-title":"Management of radiation toxicity in head and neck cancers","volume":"27","author":"Siddiqui","year":"2017","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0007","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose\u2013volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0008","first-page":"2347","article-title":"Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma","volume":"124","author":"Chera","year":"2018","journal-title":"C++ancer"},{"issue":"15_suppl","key":"10.1016\/j.ijrobp.2026.04.001_bib0009","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1200\/JCO.2017.35.15_suppl.6076","article-title":"A personalized approach using hypoxia resolution to guide curative-intent radiation dose-reduction to 30 Gy: A novel de-escalation paradigm for HPV-associated oropharynx cancers (OPC)","volume":"35","author":"Riaz","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0010","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1200\/JCO.20.03128","article-title":"Reduced-dose radiation therapy for HPV-associated oropharyngeal carcinoma (NRG Oncology HN002)","volume":"39","author":"Yom","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0011","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1016\/j.ijrobp.2021.07.321","article-title":"Dose and volume de-escalation for elective nodal regions in patients with human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) undergoing curative-intent concurrent chemoradiation (CCRT)","volume":"111","author":"Tsai","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2018.07.1088","article-title":"Prospective personalized elective nodal dose de-escalation in patients with human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) undergoing definitive concurrent chemoradiation (CCRT): Acute toxicities and tolerance","volume":"102","author":"Tsai","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0013","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/COC.0000000000000064","article-title":"Sparing bilateral neck level IB in oropharyngeal carcinoma and xerostomia outcomes","volume":"38","author":"Tam","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0014","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.prro.2016.11.002","article-title":"Sparing of high retropharyngeal nodal basins in patients with unilateral oropharyngeal carcinoma treated with intensity modulated radiation therapy","volume":"7","author":"Leeman","year":"2017","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0015","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/hed.26492","article-title":"Ipsilateral radiation for squamous cell carcinoma of the tonsil: American Radium Society appropriate use criteria executive summary","volume":"43","author":"Tsai","year":"2021","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0016","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.radonc.2017.08.002","article-title":"Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life","volume":"126","author":"Hawkins","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0017","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy","volume":"67","author":"Li","year":"2007","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0018","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.radonc.2005.10.002","article-title":"Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?","volume":"77","author":"Jellema","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0019","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ijrobp.2007.12.033","article-title":"Dose-effect relationships for the submandibular salivary glands and implications for their sparing by intensity modulated radiotherapy","volume":"72","author":"Murdoch-Kinch","year":"2008","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0020","article-title":"Impact of oral cavity dosimetry on patient reported xerostomia and dysgeusia in the setting of deintensified chemoradiotherapy","volume":"7","author":"Fried","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0021","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1007\/s00066-022-01992-5","article-title":"Impact of dosimetric factors on long-term percutaneous enteral gastrostomy (PEG) tube dependence in head and neck cancer patients after (chemo)radiotherapy\u2014results from a prospective randomized trial","volume":"198","author":"L\u00f6ser","year":"2022","journal-title":"Strahlenther Onkol"},{"issue":"16_suppl","key":"10.1016\/j.ijrobp.2026.04.001_bib0022","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1200\/JCO.2024.42.16_suppl.6007","article-title":"Intra-treatment hypoxia directed major radiation de-escalation as definitive treatment for human papillomavirus-related oropharyngeal cancer","volume":"42","author":"Lee","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/CCI.17.00070","article-title":"Modeling dose response for late dysphagia in patients with head and neck cancer in the modern era of definitive chemoradiation","volume":"1","author":"Tsai","year":"2017","journal-title":"JCO Clin Cancer Inform"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0024","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ijrobp.2017.03.034","article-title":"Dosimetric predictors of patient-reported xerostomia and dysphagia with deintensified chemoradiation therapy for HPV-associated oropharyngeal squamous cell carcinoma","volume":"98","author":"Chera","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.04.001_bib0025","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.prro.2024.05.007","article-title":"Radiation therapy for HPV-positive oropharyngeal squamous cell carcinoma: An ASTRO clinical practice guideline","volume":"14","author":"Margalit","year":"2024","journal-title":"Pract Radiat Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626005651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626005651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:34:38Z","timestamp":1793604878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301626005651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0360301626005651"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.04.001","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dosimetric Results for Organs at Risk From Radiation Therapy Dose De-Escalation to the Subclinical Region in Human Papillomavirus-Associated Oropharyngeal Cancer: A Propensity Score-Matched Analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}