{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T20:02:51Z","timestamp":1784404971228,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007316","name":"National Cancer Institute Division of Cancer Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ijrobp.2026.06.3053","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T13:31:49Z","timestamp":1784295109000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Phase 1 Trial of Dose-Escalated Hypofractionated Adaptive Radiation Therapy With Atezolizumab for Advanced Head and Neck Cancers"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1063-7932","authenticated-orcid":false,"given":"Musaddiq","family":"Awan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Tarima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Zenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Memon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica E.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Shreenivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Firat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Massey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Akakpo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bruening","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Bonate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Elmont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0001","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jama.2010.261","article-title":"Stereotactic body radiation therapy for inoperable early stage lung cancer","volume":"303","author":"Timmerman","year":"2010","journal-title":"JAMA."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0002","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ijrobp.2014.11.023","article-title":"A prospective phase 2 trial of reirradiation with stereotactic body radiation therapy plus cetuximab in patients with previously irradiated recurrent squamous cell carcinoma of the head and neck","volume":"91","author":"Vargo","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0003","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.radonc.2013.08.012","article-title":"Multi institutional phase II study of concomitant stereotactic reirradiation and cetuximab for recurrent head and neck cancer","volume":"109","author":"Lartigau","year":"2013","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0004","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijrobp.2019.03.010","article-title":"Phase 1 fractional dose-escalation study of equipotent stereotactic radiation therapy regimens for early-stage glottic larynx cancer","volume":"105","author":"Sher","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijrobp.2019.05.021","article-title":"SBRT for early stage laryngeal cancer: Progress, but not quite ready for prime time","volume":"105","author":"Young","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0006","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijrobp.2019.03.011","article-title":"Early closure of a Phase 1 clinical trial for SABR in early-stage glottic cancer","volume":"105","author":"Kang","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0007","doi-asserted-by":"crossref","first-page":"dju164","DOI":"10.1093\/jnci\/dju164","article-title":"Phase II study of accelerated hypofractionated three-dimensional conformal radiotherapy for stage T1-3 N0 M0 non-small cell lung cancer: NCIC CTG BR.25","volume":"106","author":"Cheung","year":"2014","journal-title":"J Natl Cancer Inst."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0008","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1172\/JCI67313","article-title":"Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice","volume":"124","author":"Deng","year":"2014","journal-title":"J Clin Invest."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0009","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jtho.2017.04.014","article-title":"Combined radiotherapy and anti-PD-L1 antibody synergistically enhances antitumor effect in non-small cell lung cancer","volume":"12","author":"Gong","year":"2017","journal-title":"J Thorac Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2019.01.018","article-title":"Selection of lymph node target volumes for definitive head and neck radiation therapy: A 2019 update","volume":"134","author":"Biau","year":"2019","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0011","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.0006-341X.2000.01177.x","article-title":"Sequential designs for phase I clinical trials with late-onset toxicities","volume":"56","author":"Cheung","year":"2000","journal-title":"Biometrics."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0012","first-page":"753","article-title":"Herpes simplex virus-1 (HSV-1) infection in radiation-induced oral mucositis","volume":"14","author":"Nicolatou-Galitis","year":"2006","journal-title":"Support Care Cancer."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0013","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/AAC.33.6.862","article-title":"Effect of acyclovir on radiation- and chemotherapy-induced mouth lesions","volume":"33","author":"Bubley","year":"1989","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0014","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1079-2104(97)90342-5","article-title":"Reactivation of oral herpes simplex virus: Implications for clinical management of herpes simplex virus recurrence during radiotherapy","volume":"84","author":"Oakley","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0015","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0030-4220(90)90239-O","article-title":"Oral herpes simplex virus infection in patients receiving head and neck radiation","volume":"69","author":"Redding","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/924619","article-title":"PD-L1-expressing dendritic cells contribute to viral resistance during acute HSV-1 infection","volume":"2012","author":"Bryant-Hudson","year":"2012","journal-title":"Clin Dev Immunol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0017","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1470-2045(20)30737-3","article-title":"Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: A randomised, double-blind, placebo-controlled, multicentre, phase 3 trial","volume":"22","author":"Lee","year":"2021","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0018","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.annonc.2022.10.006","article-title":"Pembrolizumab versus cetuximab concurrent with radiotherapy in patients with locally advanced squamous cell carcinoma of head and neck unfit for cisplatin (GORTEC 2015-01 PembroRad): A multicenter, randomized, phase II trial","volume":"34","author":"Tao","year":"2023","journal-title":"Ann Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0019","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.oraloncology.2015.04.007","article-title":"Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience","volume":"51","author":"Scher","year":"2015","journal-title":"Oral Oncol."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/lary.20716","article-title":"Chemoradiation for patients with advanced oral cavity cancer","volume":"120","author":"Stenson","year":"2010","journal-title":"Laryngoscope."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0021","first-page":"1381","article-title":"Three-week hypofractionated radiotherapy in early glottic cancer-A single institution retrospective study","volume":"16","author":"Sudha","year":"2022","journal-title":"Ecancermedicalscience."},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0022","article-title":"Patterns of response in head and neck cancer subregions using daily quantitative MRI from MR-guided radiation therapy","volume":"56","author":"Bonate","year":"2025","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.06.3053_bib0023","article-title":"Quantitative magnetic resonance imaging responses in head and neck cancer patients treated with magnetic resonance-guided hypofractionated radiation therapy","volume":"33","author":"Bonate","year":"2025","journal-title":"Phys Imaging Radiat Oncol."}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626039118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626039118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:23:46Z","timestamp":1784402626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301626039118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":23,"alternative-id":["S0360301626039118"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.06.3053","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase 1 Trial of Dose-Escalated Hypofractionated Adaptive Radiation Therapy With Atezolizumab for Advanced Head and Neck Cancers","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.06.3053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}