{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:49:18Z","timestamp":1785934158264,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ijrobp.2026.07.003","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:32:01Z","timestamp":1784179921000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrahypofractionated Whole Breast Irradiation in Early-Stage Breast Cancer: An Italian Multicenter Observational Study"],"prefix":"10.1016","author":[{"given":"Isabella","family":"Palumbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Giulia","family":"Becchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmen","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fozza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Lazzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Falivene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Baldissera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Ingrosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Felice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Nuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Anselmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Marazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Carnevale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Blandino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Musu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cucciarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Rago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Damiana","family":"Andrulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mascioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Ferraioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Antonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Prisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"La Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Bacchiddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Bonzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatrice","family":"Campoccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Bini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Aristei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2026.07.003_bib0001","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","article-title":"Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomised trials","volume":"378","author":"Darby","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0002","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1470-2045(06)70699-4","article-title":"Effect of radiotherapy fraction size on tumour control in patient with early-stage breast cancer after local tumour excision: Long-term results of a randomised trial","volume":"7","author":"Owen","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0003","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1470-2045(08)70077-9","article-title":"The UK standardisation of breast radiotherapy (START) trial A of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"9","author":"Bentzen","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0004","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0140-6736(08)60348-7","article-title":"The UK Standardisation of Breast Radiotherapy (START) trial B of radiotherapy hypofractionation for treatment of early breast cancer: A randomised trial","volume":"371","author":"Bentzen","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0005","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa0906260","article-title":"Long-term result of hypofractionated radiation therapy for breast cancer","volume":"362","author":"Whelan","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0006","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.clon.2024.07.007","article-title":"Cost-outcome of radiotherapy for local control and overall survival benefits in breast cancer","volume":"36","author":"Powell","year":"2024","journal-title":"Clin Oncol (R Coll Radiol)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0007","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0140-6736(20)30932-6","article-title":"Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5 year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3","volume":"395","author":"Brunt","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.clon.2020.03.006","article-title":"International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic","volume":"32","author":"Coles","year":"2020","journal-title":"Clin Oncol (R Coll Radiol)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0009","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1016\/j.clon.2020.11.027","article-title":"Accelerated adaptation of ultrahypofractionated radiation therapy for breast cancer at the time of the COVID-19 pandemic","volume":"33","author":"Machiels","year":"2021","journal-title":"Clin Oncol (R Coll Radiol)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13014-025-02669-w","article-title":"Implementation of ultra-hypofractionated radiotherapy for breast cancer in the Netherlands in 2020-2023, using registry data and questionnaires","volume":"20","author":"Eijkelboom","year":"2025","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0011","unstructured":"Postoperative radiotherapy for breast cancer: Hypofractionation RCR consensus statements. 2021.https:\/\/www.rcr.ac.uk\/our-services\/all-our-publications\/clinical-oncology-publications\/postoperative-radiotherapy-for-breast-cancer-hypofractionation-rcr-consensus-statements\/. Accessed March 5, 2026."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0012","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S1470-2045(21)00539-8","article-title":"European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer","volume":"23","author":"Meattini","year":"2022","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0013","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s11547-022-01563-9","article-title":"The Italian Association for Radiotherapy and Clinical Oncology (AIRO) position statements for postoperative breast cancer radiation therapy volume, dose, and fractionation","volume":"127","author":"Meattini","year":"2022","journal-title":"Radiol Med"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0014","unstructured":"NCCN. guidelineshttps:\/\/www.nccn.org\/professionalphysician_gls\/pdf\/breast.pdf. Accessed March 5, 2026."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0015","unstructured":"Associazione Italiana di Radioterapia Oncologica (AIRO) Gruppo di Lavoro per la Patologia Mammaria. La Radioterpia dei Tumori Della Mammella Indicazioni E Criteri Guida. 2013. http:\/\/www.radioterapiaitalia.it. Accessed March 5, 2026."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/03008916221088885","article-title":"AIRO breast cancer group best clinical practice 2022 update","volume":"108","author":"Ciabattoni","year":"2022","journal-title":"Tumori"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00066-018-1378-z","article-title":"Heart toxicity from breast cancer radiotherapy: Current findings, assessment, and prevention","volume":"195","author":"Piroth","year":"2019","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0018","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/annonc\/mdz173","article-title":"Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"30","author":"Cardoso","year":"2019","journal-title":"Ann Oncol."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0019","series-title":"Common Terminology Criteria for Adverse Events (CTCAE) version 5.0","article-title":"Cancer therapy evaluation program","year":"2017"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0360-3016(79)90729-6","article-title":"Analysis of cosmetic results following primary radiotherapy for stages I and II carcinoma of the breast","volume":"5","author":"Harris","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0021","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clon.2008.03.017","article-title":"Evaluation of a method for grading late photographic change in breast appearance after radiotherapy for early breast cancer","volume":"20","author":"Haviland","year":"2008","journal-title":"Clin Oncol (R Coll Radiol)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0022","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF00439229","article-title":"The interpretation of scores from the EORTC quality of life questionnaire QLQ-C30","volume":"5","author":"King","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0023","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1200\/JCO.1996.14.10.2756","article-title":"The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: First results from a three-country field study","volume":"14","author":"Sprangers","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0024","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.canrad.2021.07.036","volume":"26","author":"Chaffai","year":"2022","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0025","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.3390\/biomedicines10102568","article-title":"Ultra-hypofractionation for whole-breast irradiation in early breast cancer: Interim analysis of a prospective study","volume":"10","author":"Sigaudi","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0026","article-title":"Acute skin toxicity of ultra-hypofractionated whole breast radiotherapy with simultaneous integrated boost for early breast cancer","volume":"41","author":"Montero","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0027","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s12282-024-01577-3","article-title":"Acute adverse events of ultra-hypofractionated whole-breast irradiation after breast-conserving surgery for early breast cancer in Japan: An interim analysis of the multi-institutional phase II UPBEAT study","volume":"31","author":"Tokuda","year":"2024","journal-title":"Breast Cancer"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0028","doi-asserted-by":"crossref","first-page":"e333","DOI":"10.1016\/j.clon.2024.06.045","article-title":"Feasibility and safety of the \"One-Week Breast Radiation Therapy\" program","volume":"36","author":"Ba","year":"2024","journal-title":"Clin Oncol (R Coll Radiol)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0029","first-page":"611","article-title":"Ultra-hypofractionated whole breast radiotherapy with automated hybrid-VMAT technique: A pilot study on safety, skin toxicity and aesthetic outcomes","volume":"16","author":"Boccardi","year":"2024","journal-title":"Breast Cancer (Dove Med Press)."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0030","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1007\/s12282-024-01626-x","article-title":"Acute toxicity of hypofractionated radiotherapy for Japanese breast cancer patients after surgery: A single center prospective observational study (HyPORT-BC)","volume":"31","author":"Nakamura","year":"2024","journal-title":"Breast Cancer"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0031","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1007\/s12094-024-03786-w","article-title":"Ultra-hypofractionated 5-fraction radiation therapy for early breast cancer into whole breast and regional nodes: experience in a tertiary hospital","volume":"27","author":"Tejada Ortigosa","year":"2025","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0032","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.ijrobp.2026.02.233","article-title":"Early safety of ultra-hypofractionated whole breast irradiation and sequential tumor bed boost for early breast cancer (SHIFT): A multicenter, phase 2 trial","volume":"125","author":"Zheng","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0033","article-title":"Tolerance of adjuvant ultrahypofractionated whole-breast radiation therapy employing moderately hypofractionated sequential boost: A single institution analysis","volume":"10","author":"Unterkirhere","year":"2025","journal-title":"Adv Radiat Oncol."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0034","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijrobp.2025.07.1447","article-title":"HYPofractionated adjuvant radioTherapy in 1 versus 2 weeks in high-risk patients with breast cancer (HYPART): Acute toxicity results","volume":"124","author":"Yadav","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0035","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1001\/jama.2023.4855","article-title":"Randomized trials vs real-world evidence: How can both inform decision-making?","volume":"329","author":"Sheldrick","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0036","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2016.02.027","article-title":"Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial","volume":"120","author":"Brunt","year":"2016","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/WWBF1044","article-title":"One versus three weeks hypofractionated whole breast radiotherapy for early breast cancer treatment: The FAST-Forward phase III RCT","volume":"27","author":"Brunt","year":"2023","journal-title":"Health Technol Assess"},{"issue":"18","key":"10.1016\/j.ijrobp.2026.07.003_bib0038","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3390\/cancers18071100","article-title":"Interleukin-18 as a potential biomarker for radiotherapy-related pain in breast cancer: Implications for personalized pain management","volume":"28","author":"McMahon","year":"2026","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0039","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1200\/JCO.20.01703","article-title":"Toward improving patients' experiences of acute toxicity from breast radiotherapy: Insights from the analysis of patient-reported outcomes in a large multicenter cohort","volume":"38","author":"Jagsi","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0040","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.critrevonc.2005.06.003","article-title":"Use of comprehensive geriatric assessment in older cancer patients: Recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG)","volume":"55","author":"Extermann","year":"2005","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0041","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/S1470-2045(20)30741-5","article-title":"Updated recommendations regarding the management of older patients with breast cancer: A joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG)","volume":"22","author":"Biganzoli","year":"2021","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.111310","article-title":"Acute toxicity and quality of life after 5-fraction versus 15-fraction adjuvant radiotherapy following conventional or oncoplastic breast-conserving surgery - a real-world prospective cohort study","volume":"214","author":"Mink van der Molen","year":"2026","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0043","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2478\/raon-2018-0026","article-title":"Breast size impact on adjuvant radiotherapy adverse effects and dose parameters in treatment planning","volume":"52","author":"Ratosa","year":"2018","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2025.103881","article-title":"The 2024 Assisi think tank on breast cancer: Focus on the use of a tumour bed boost after breast conserving therapy","volume":"80","author":"Arenas","year":"2025","journal-title":"Breast"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0045","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.radonc.2018.06.020","article-title":"Predictors for poor cosmetic outcome in patients with early stage breast cancer treated with breast conserving therapy: Results of the Young Boost Trial","volume":"128","author":"Brouwers","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0046","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.breast.2013.07.047","article-title":"Smoking as an independent risk factor for severe skin reactions due to adjuvant radiotherapy for breast cancer","volume":"22","author":"Sharp","year":"2013","journal-title":"Breast"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110574","article-title":"Breast induration and irradiated volume in the DBCG HYPO trial: The impact of age, smoking, and boost","volume":"201","author":"Thomsen","year":"2024","journal-title":"Radiother Oncol."},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0048","article-title":"The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review","volume":"24","author":"Wong","year":"2020","journal-title":"Cancer Treat Res Commun"},{"key":"10.1016\/j.ijrobp.2026.07.003_bib0049","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S1470-2045(26)00076-8","volume":"27","author":"Brunt","year":"2026","journal-title":"Lancet Oncol."}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626039969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626039969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:24:31Z","timestamp":1785932671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301626039969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":49,"alternative-id":["S0360301626039969"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.07.003","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultrahypofractionated Whole Breast Irradiation in Early-Stage Breast Cancer: An Italian Multicenter Observational Study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}