{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:03:48Z","timestamp":1790111028651,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017397","name":"UVA Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA234281"],"award-info":[{"award-number":["R01CA234281"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ijrobp.2026.08.012","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:36Z","timestamp":1787067696000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Forecasting Time-Dependent Radiation-Induced Lymphocyte Depletion in a Clinical Trial on Early-Stage Lung Cancer"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7217-389X","authenticated-orcid":false,"given":"Cam","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-0276","authenticated-orcid":false,"given":"Jonathan","family":"Colen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4283-1609","authenticated-orcid":false,"given":"Krishni","family":"Wijesooriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2026.08.012_bib0001","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jtcvs.2009.12.054","article-title":"Stereotactic body radiation therapy versus surgical resection for stage I non\u2013small cell lung cancer","volume":"140","author":"Crabtree","year":"2010","journal-title":"J Thora Cardiovasc Surg"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0002","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.radonc.2009.08.003","article-title":"Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: A meta-analysis","volume":"95","author":"Grutters","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0003","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1182\/blood-2009-02-206870","article-title":"Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment","volume":"114","author":"Lee","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0004","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ijrobp.2011.09.049","article-title":"Maximizing tumor immunity with fractionated radiation","volume":"83","author":"Schaue","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0005","first-page":"575","article-title":"Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis","volume":"43","author":"Ohba","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2172-11-19","article-title":"Tumor infiltrating lymphocytes: An intriguing player in the survival of colorectal cancer patients","volume":"11","author":"Deschoolmeester","year":"2010","journal-title":"BMC Immunol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0007","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/onc.2009.416","article-title":"Immune infiltration in human tumors: A prognostic factor that should not be ignored","volume":"29","author":"Pag\u00e8s","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0008","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/cncr.23712","article-title":"Predominant infiltration of macrophages and CD8+T cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer","volume":"113","author":"Kawai","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0009","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1200\/JCO.2007.15.0284","article-title":"Long-term survival for patients with non\u2013small-cell lung cancer with intratumoral lymphoid structures","volume":"26","author":"Dieu-Nosjean","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1201500","article-title":"A review on lymphocyte radiosensitivity and its impact on radiotherapy","volume":"13","author":"Paganetti","year":"2023","journal-title":"Front Oncol."},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0011","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2307\/3577549","article-title":"Radiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in vitro colony formation assay","volume":"123","author":"Nakamura","year":"1990","journal-title":"Radiat Res."},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0012","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.radonc.2021.01.034","article-title":"Risk and impact of radiation related lymphopenia in lung cancer: A systematic review and meta-analysis","volume":"157","author":"Upadhyay","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0013","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.jtho.2020.06.008","article-title":"Radiotherapy-related lymphopenia affects overall survival in patients with lung cancer","volume":"15","author":"Abravan","year":"2020","journal-title":"J Thor Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109804","article-title":"Impact of radiation dose to the immune system on disease progression and survival for early-stage non-small cell lung cancer treated with stereotactic body radiation therapy","volume":"186","author":"Wang","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0015","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0140-6736(23)01384-3","article-title":"Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: An open-label, randomised, phase 2 trial","volume":"402","author":"Chang","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0016","doi-asserted-by":"crossref","unstructured":"Pircher A, S\u00f3t\u00e9r S, Eaton M, et al. ESMO Immuno-Oncology Congress, Dec 2024, Geneva-Switzerland Abstract 117O \u2013 Stereotactic Body Radiotherapy (SBRT) With Pembrolizumab (pembro) for Unresected Stage I\/II Non-Small-Cell Lung Cancer (NSCLC): The Randomized, Double-Blind, Phase 3 KEYNOTE-867 Study. https:\/\/doi.org\/10.1016\/j.iotech.2024.100746","DOI":"10.1016\/j.iotech.2024.100746"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0017","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/07357907.2012.762780","article-title":"The etiology of treatment-related lymphopenia in patients with malignant gliomas: Modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells","volume":"31","author":"Yovino","year":"2013","journal-title":"Cancer Invest"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0018","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac16ea","article-title":"HEDOS\u2014a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations","volume":"66","author":"Shin","year":"2021","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-018-0952-y","article-title":"Modelling the immunosuppressive effect of liver SBRT by simulating the dose to circulating lymphocytes: an in-silico planning study","volume":"13","author":"Basler","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0020","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac4da4","article-title":"A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy","volume":"67","author":"Xing","year":"2022","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0021","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab6c41","article-title":"4D blood flow model for dose calculation to circulating blood and lymphocytes","volume":"65","author":"Hammi","year":"2020","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0022","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad02d6","article-title":"A stochastic model of blood flow to calculate blood dose during radiotherapy","volume":"68","author":"Beekman","year":"2023","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0023","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.ijrobp.2017.06.351","article-title":"Higher radiation dose to immune system is correlated with poorer survival in patients with Stage III non\u2013small cell lung cancer: A secondary study of a phase 3 cooperative group trial (NRG Oncology RTOG 0617)","volume":"99","author":"Jin","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0024","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijrobp.2019.05.064","article-title":"Impact of radiation dose to the host immune system on tumor control and survival for stage III non-small cell lung cancer treated with definitive radiation therapy","volume":"105","author":"Ladbury","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0025","article-title":"Lymphocyte depletion rate as a biomarker of radiation dose to circulating lymphocytes during fractionated partial-body radiation therapy","volume":"7","author":"Ellsworth","year":"2022","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0026","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1002\/mp.17181","article-title":"Predicting radiation-inducedimmune suppression in lung cancer patientstreated with stereotactic body radiation therapy","volume":"51","author":"Colen","year":"2024","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0027","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.imlet.2006.10.009","article-title":"Lymphocyte numbers and subsets in the human blood","volume":"108","author":"Blum","year":"2007","journal-title":"Immunol Lett"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0028","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.it.2007.08.009","article-title":"Do most lymphocytes in humans really reside in the gut?","volume":"28","author":"Ganusov","year":"2007","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0029","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308511120","article-title":"The total mass, number, and distribution of immune cells in the human body","volume":"120","author":"Sender","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/jcp.s3-13.1.63","article-title":"Lymphocytes. 3. Distribution. Distribution of lymphocytes in health","volume":"s3-13","author":"Ford","year":"1979","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003586","article-title":"Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism","volume":"10","author":"Ganusov","year":"2014","journal-title":"PLOS Comput Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2026.07.012","article-title":"First Measurement: Proactively Sparing the Immune System During SBRT to Early-Stage Lung Cancer-A Randomized Phase II Study","author":"Wijesooriya","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0034","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.ijrobp.2025.03.080","article-title":"Radiation-induced lymphopenia: In-silico replications of preclinical studies suggest importance of dose to lymphoid organs","volume":"123","author":"Beekman","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0035","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ae0d29","article-title":"Predicting lymphocyte dose and surviving fraction for VMAT and IMPT treatments with a dynamic lymphocyte flow model for locally advanced cervical cancer","volume":"70","author":"C Kuipers","year":"2025","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0036","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.radonc.2019.11.014","article-title":"A framework for modeling radiation induced lymphopenia in radiotherapy","volume":"144","author":"Jin","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0037","article-title":"Radiation Therapy Oncology Group RTOG 0813 seamless Phase I\/II study of stereotactic lung radiotherapy (SBRT) For early stage, centrally located, nonsmall cell lung cancer (NSCLC) in medically inoperable patients","author":"Bezjak","year":"2009","journal-title":"Update"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0038","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2013.06.016","article-title":"Radiation Therapy Oncology Group (RTOG) protocol 0915: A randomized phase 2 study comparing 2 stereotactic body radiation therapy (SBRT) schedules for medically inoperable patients with Stage I peripheral non-small cell lung cancer","volume":"87","author":"Videtic","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0039","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijrobp.2004.12.060","article-title":"CT-based definition of thoracic lymph node stations: an atlas from the University of Michigan","volume":"63","author":"Chapet","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/CCI.19.00041","article-title":"Development and usage of eContour, a novel, three-dimensional, image-based web site to facilitate access to contouring guidelines at the point of care","volume":"3","author":"Sherer","year":"2019","journal-title":"JCO Clin Cancer Inform"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0041","series-title":"Springer eBooks","first-page":"151","article-title":"Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes","author":"Ganusov","year":"2021"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0042","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.3389\/fimmu.2019.01492","article-title":"Estimating residence times of lymphocytes in ovine lymph nodes","volume":";10","author":"McDaniel","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0043","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ijrobp.2009.11.040","article-title":"Distribution of proliferating bone marrow in adult cancer patients determined using FLT-PET imaging","volume":"79","author":"Hayman","year":"2011","journal-title":"Int J Radiat Oncol, Biol, Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0044","series-title":"Immunobiology: The Immune System in Health and Disease. 5th edition","article-title":"Generation of lymphocytes in bone marrow and thymus","author":"Janeway","year":"2001"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0045","doi-asserted-by":"crossref","first-page":"01TR01","DOI":"10.1088\/1361-6560\/aaf26a","article-title":"The linear quadratic model: Usage, interpretation and challenges","volume":"64","author":"McMahon","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0046","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejrad.2018.07.005","article-title":"Reference values of liver volume in Caucasian population and factors influencing liver size","volume":"106","author":"Kromrey","year":"2018","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0047","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nature Methods"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0048","series-title":"Solving Least Squares Problems","author":"Lawson","year":"1995"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0049","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ad3c8d","article-title":"LymphoDose: A lymphocyte dose estimation framework\u2014application to brain radiotherapy","volume":"69","author":"de Kermenguy","year":"2024","journal-title":"Phys Med Biol"},{"issue":"10","key":"10.1016\/j.ijrobp.2026.08.012_bib0050","article-title":"Lymph Node Dose Is Associated with Immune Suppression and Poor Overall Survival in Locally Advanced Non-Small Cell Lung Cancer (NSCLC): TU-1120-BRC-5","volume":"52","author":"Nguyen","year":"2025","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0051","article-title":"Dosimetric effect of thymus and thoracic duct on radiation-induced lymphopenia in patients with primary lung cancer who received thoracic radiation","volume":"8","author":"Zhang","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0052","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijrobp.2025.07.1429","article-title":"Radiation-induced lymphopenia: From mathematical modeling towards mechanistic learning","volume":"124","author":"de Kermenguy","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0053","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/mp.15584","article-title":"A hybrid deep learning model for forecasting lymphocyte depletion during radiation therapy","volume":"49","author":"Ebrahimi","year":"2022","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0054","unstructured":"Nguyen C, Colen J, Wijesooriya K. Forecasting Time-Dependent Radiation Induced Lymphocyte Kill In Locally Advanced Non-Small Cell Lung Cancer (NSCLC). In 2026 Joint AAPM| COMP Annual Meeting & Exhibition 2026 Jul 19. AAPM. https:\/\/aapm.confex.com\/aapm\/2026am\/meetingapp.cgi\/Paper\/27445"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123963","article-title":"Preliminary study of the effect of stereotactic body radiotherapy (SBRT) on the immune system in lung cancer patients unfit for surgery: Immunophenotyping analysis","volume":"19","author":"Navarro-Mart\u00edn","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0056","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41698-023-00358-z","article-title":"Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer","volume":"7","author":"Gkika","year":"2023","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0057","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.immuni.2014.12.007","article-title":"Tissue-resident memory T cells","volume":"41","author":"Schenkel","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.ijrobp.2026.08.012_bib0058","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2015.03.031","article-title":"Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance","volume":"161","author":"Steinert","year":"2015","journal-title":"Cell"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626041908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626041908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:10:03Z","timestamp":1790107803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301626041908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":57,"alternative-id":["S0360301626041908"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.08.012","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forecasting Time-Dependent Radiation-Induced Lymphocyte Depletion in a Clinical Trial on Early-Stage Lung Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}