{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:08:41Z","timestamp":1789160921882,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","redjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ijrobp.2026.08.023","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:23Z","timestamp":1787067683000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Phase I Study of Cyclical Hypofractionated Palliative Radiation Therapy (Quad Shot) for Central Lung Tumors in Patients With Stage IV Non-Small Cell Lung Cancer: Results From the PROMISE 006 Trial"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-472X","authenticated-orcid":false,"given":"Y. Helen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsheen","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Gelblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Yorke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan T.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin F.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Toumbacaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emali","family":"Khalyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narek","family":"Shaverdian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Guttmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon S.","family":"Imber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneeth","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham J.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rimner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Shepherd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2026.08.023_bib0001","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/JTO.0b013e3181c5920c","article-title":"Trends in stage distribution for patients with non-small cell lung cancer: A National Cancer Database survey","volume":"5","author":"Morgensztern","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0002","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1200\/JCO.2007.15.3312","article-title":"Palliative thoracic radiotherapy for lung cancer: A systematic review","volume":"26","author":"Fairchild","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0003","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/bjc.1991.62","article-title":"Inoperable non-small-cell lung cancer (NSCLC): A Medical Research Council randomised trial of palliative radiotherapy with two fractions or ten fractions. Report to the Medical Research Council by its Lung Cancer Working Party","volume":"63","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0004","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0936-6555(05)80446-7","article-title":"Palliative radiotherapy for lung cancer: Two versus five fractions","volume":"9","author":"Rees","year":"1997","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0005","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.bjc.6602477","article-title":"A prospective, randomised study to compare two palliative radiotherapy schedules for non-small-cell lung cancer (NSCLC)","volume":"92","author":"Senkus-Konefka","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0006","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0936-6555(96)80101-4","article-title":"Randomized trial of two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status","volume":"8","author":"Lander","year":"1996","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0007","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1200\/JCO.2005.01.685","article-title":"Results of the Dutch National study of the palliative effect of irradiation using two different treatment schemes for non-small-cell lung cancer","volume":"23","author":"Kramer","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0008","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/bjc.1992.196","volume":"65","author":"Bleehen","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0009","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.prro.2011.01.005","article-title":"Palliative thoracic radiotherapy in lung cancer: An American Society for Radiation Oncology evidence-based clinical practice guideline","volume":"1","author":"Rodrigues","year":"2011","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0010","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.oraloncology.2015.07.011","article-title":"Palliative head and neck radiotherapy with the RTOG 8502 regimen for incurable primary or metastatic cancers","volume":"51","author":"Lok","year":"2015","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0011","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/jpm.2006.0192","article-title":"Palliation of pelvic and head and neck cancer with paclitaxel and a novel radiotherapy regimen","volume":"10","author":"Carrascosa","year":"2007","journal-title":"J Palliat Med"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0012","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0360-3016(89)90120-X","article-title":"Phase II study of multiple daily fractionations in the palliation of advanced pelvic malignancies: Preliminary report of RTOG 8502","volume":"17","author":"Spanos","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0013","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2005.10.008","article-title":"The 'QUAD SHOT'\u2013a phase II study of palliative radiotherapy for incurable head and neck cancer","volume":"77","author":"Corry","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0014","doi-asserted-by":"crossref","first-page":"685","DOI":"10.21873\/anticanres.11364","article-title":"Hypofractionated palliative radiotherapy with concurrent radiosensitizing chemotherapy for advanced head and neck cancer using the \"QUAD-SHOT Regimen\"","volume":"37","author":"Gamez","year":"2017","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0015","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/cancers16051049","article-title":"Palliative quad shot radiation therapy with or without concurrent immune checkpoint inhibition for head and neck cancer","volume":"16","author":"Upadhyay","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0016","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1200\/JCO.2006.07.5937","article-title":"Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer","volume":"24","author":"Timmerman","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0017","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10585-018-9942-6","article-title":"Radiotherapy in palliation of thoracic tumors: A phase I-II study (SHARON project)","volume":"35","author":"Farina","year":"2018","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0018","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25602-7","article-title":"Short course palliative radiotherapy in advanced solid tumors: A pooled analysis (the SHARON project)","volume":"12","author":"Donati","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamaoncol.2021.7664","article-title":"Palliative radiation for advanced central lung tumors with intentional avoidance of the esophagus (PROACTIVE): A phase 3 randomized clinical trial","volume":"8","author":"Louie","year":"2022","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0020","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ijrobp.2024.03.050","article-title":"Stereotactic radiation for ultra-central non-small cell lung cancer: A safety and efficacy trial (SUNSET)","volume":"120","author":"Giuliani","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0021","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.ijrobp.2025.08.060","article-title":"Five-year survival and safety of SABR in patients with unresectable locally advanced non-small cell lung cancer unfit for concurrent radio-chemotherapy: Focus on patterns of local recurrence from the START-NEW-ERA non-randomized phase 2 trial","volume":"124","author":"Arcidiacono","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002143.pub3","article-title":"Palliative radiotherapy regimens for patients with thoracic symptoms from non-small cell lung cancer","volume":"1","author":"Stevens","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijrobp.2026.08.023_bib0023","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1200\/JCO.2004.06.123","article-title":"Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: A national phase III trial","volume":"22","author":"Sundstr\u00f8m","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626042021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301626042021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:44:43Z","timestamp":1789159483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301626042021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"alternative-id":["S0360301626042021"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.08.023","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase I Study of Cyclical Hypofractionated Palliative Radiation Therapy (Quad Shot) for Central Lung Tumors in Patients With Stage IV Non-Small Cell Lung Cancer: Results From the PROMISE 006 Trial","name":"articletitle","label":"Article Title"},{"value":"International Journal of Radiation Oncology*Biology*Physics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijrobp.2026.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}