{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:53:39Z","timestamp":1768452819122,"version":"3.49.0"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION:<\/jats:title>\n Primary squamous cell carcinoma (SCC) of the tympanic membrane is exceptionally rare. We describe the history, investigation and management of this disease.<\/jats:p>\n <\/jats:sec>\n \n PRESENTATION OF CASE:<\/jats:title>\n A 68-year-old woman presented with a three month history of intermittent otorrhoea and external ear canal (EAC) pruritus. Otoscopy revealed a polypoidal granular nodule, confined to the posterior aspect of the tympanic membrane. Examination under anaesthesia (EUA) confirmed that the lesion was confined to the tympanic membrane, with a surrounding rim of normal drum. Biopsies were consistent with well differentiated SCC.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n Following discussion at multi-disciplinary team meeting for treatment planning, the patient underwent lateral temporal bone resection with ipsilateral superficial parotidectomy and selective neck dissection. Post-operative histology confirmed an SCC confined to the tympanic membrane.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n SCC of the tympanic membrane is an extremely rare condition. As with early temporal bone SCC, surgical resection with adjacent structure clearance remains the primary treatment modality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2012.08.012","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T06:15:27Z","timestamp":1348035327000},"page":"33-35","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Isolated primary squamous cell carcinoma of the tympanic membrane"],"prefix":"10.1097","volume":"4","author":[{"given":"Clifton","family":"Wijaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald P.","family":"McShane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-10-20260114","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1288\/00005537-195207000-00006","article-title":"Squamous cell carcinoma of the tympanic membrane","volume":"62","author":"Gisselson","year":"1952","journal-title":"Laryngoscope"},{"key":"R2-10-20260114","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/00129492-200209000-00034","article-title":"Isolated squamous cell carcinoma of the tympanic membrane","volume":"23","author":"Somers","year":"2002","journal-title":"Otology and Neurotology"},{"key":"R3-10-20260114","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1017\/S0022215110002203","article-title":"Persistent otorrhoea with an abnormal tympanic membrane secondary to squamous cell carcinoma of the tympanic membrane","volume":"125","author":"de Zoysa","year":"2011","journal-title":"Journal of Laryngology and Otology"},{"key":"R4-10-20260114","first-page":"582","article-title":"Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system","volume":"21","author":"Moody","year":"2000","journal-title":"American Journal of Otology"},{"key":"R6-10-20260114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.mlg.0000154744.71184.c7","article-title":"The outcome of radical surgery and postoperative radiotherapy for squamous carcinoma of the temporal bone","volume":"115","author":"Moffat","year":"2005","journal-title":"Laryngoscope"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212001575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212001575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304010-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:20:53Z","timestamp":1768396853000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304010-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2012.08.012","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}