{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:30:54Z","timestamp":1772796654389,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Rhinophyma is the most common clinical manifestation of phytamous rosacea. While conservative methods (e.g. topical or systemic antibiotics, retinoids) are effective for the treatment of acne rosacea, a surgical intervention is appropriate and required in established rhinophyma. A variety of surgical techniques to reduce proliferated tissue have been reported. However, a surgical \u201cgold standard\u201d for treating the distorting phymatous skin alterations has not yet been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>This case report details a novel surgical approach: the combination of a bovine collagen\u2013elastin with simultaneous autologous non-meshed split-thickness skin grafting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Our approach was based on the following considerations: deep excision facilitates complete removal of diseased tissue that ultimately reduces the risk of recurrence in contrast to commonly applied methods relying predominantly on superficial lesion removal with subsequent spontaneous re-epithelialization. The application of a dermal substitute to create a neodermis covered by split-thickness autologous skin grafting may serve as a functionally and aesthetically appropriate model without requiring the recruitment of donor sites for full-thickness skin grafts or even local flaps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The combination of deep excision and single-step replacement of epidermal\u2013dermal components may ultimately avoid the recurrence of rhinophyma and contribute to a full skin repair leading to satisfactory functional and aesthetic outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2012.11.003","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T20:46:00Z","timestamp":1352493960000},"page":"200-203","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["The surgical treatment of rhinophyma\u2014Complete excision and single-step reconstruction by use of a collagen\u2013elastin matrix and an autologous non-meshed split-thickness skin graft"],"prefix":"10.1097","volume":"4","author":[{"given":"Harald-Franz","family":"Selig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Benjamin","family":"Lumenta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars-Peter","family":"Kamolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-17-20260114","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMcp042829","article-title":"Clinical practice. Rosacea","volume":"352","author":"Powell","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"R2-17-20260114","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea","volume":"46","author":"Wilkin","year":"2002","journal-title":"Journal of the American Academy of Dermatology"},{"key":"R4-17-20260114","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/SAP.0b013e31815f12d2","article-title":"Rhinophyma: diagnosis and treatment options for a disfiguring tumor of the nose","volume":"61","author":"Sadick","year":"2008","journal-title":"Annals of Plastic Surgery"},{"key":"R5-17-20260114","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.bjps.2008.09.026","article-title":"Management of full-thickness skin defects in the hand and wrist region: first long-term experiences with the dermal matrix Matriderm\u00ae","volume":"63","author":"Haslik","year":"2010","journal-title":"Journal of Plastic, Reconstructive and Aesthetic Surgery"},{"key":"R6-17-20260114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1742-481X.2010.00687.x","article-title":"The use of Matriderm and autologous skin grafting in the treatment of diabetic ulcers: a case report","volume":"7","author":"Cervelli","year":"2010","journal-title":"International Wound Journal"},{"key":"R7-17-20260114","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.burns.2009.12.002","article-title":"Matriderm\u00ae in depth-adjusted reconstruction of necrotising fasciitis defects","volume":"36","author":"Ryssel","year":"2010","journal-title":"Burns"},{"key":"R8-17-20260114","doi-asserted-by":"crossref","first-page":"60e","DOI":"10.1097\/PRS.0b013e3181c725e5","article-title":"Early excision and application of matriderm with simultaneous autologous skin grafting in facial burns","volume":"125","author":"Atherton","year":"2010","journal-title":"Plastic and Reconstructive Surgery"},{"key":"R9-17-20260114","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00266-010-9639-y","article-title":"Aesthetic improvements of skin grafts in nasal tip reconstruction","volume":"35","author":"Riml","year":"2011","journal-title":"Aesthetic Plastic Surgery"},{"key":"R10-17-20260114","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1177\/000348949710601111","article-title":"Excision of rhinophyma with the carbon dioxide laser: a ten-year experience","volume":"106","author":"Karim Ali","year":"1997","journal-title":"Annals of Otology, Rhinology and Laryngology"},{"key":"R11-17-20260114","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0025-6196(12)61576-6","article-title":"Spectrum of results after treatment of rhinophyma with the carbon dioxide laser","volume":"66","author":"el-Azhary","year":"1991","journal-title":"Mayo Clinic Proceedings"},{"key":"R12-17-20260114","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00266-011-9802-0","article-title":"Malignancies within rhinophyma: report of three new cases and review of the literature","volume":"36","author":"Lazzeri","year":"2011","journal-title":"Aesthetic Plastic Surgery"},{"key":"R13-17-20260114","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00266-001-0039-1","article-title":"Surgical treatment of rhinophyma: a comparison of techniques","volume":"26","author":"Bogetti","year":"2002","journal-title":"Aesthetic Plastic Surgery"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212002040?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212002040?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304020-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:00:47Z","timestamp":1768395647000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304020-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2012.11.003","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}