{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:34:27Z","timestamp":1792146867244,"version":"4.4.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":200,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in late adult life. But primary visceral malignant fibrous histiocytoma is a very rare entity. In peripheries, it is known to have an aggressive behavior but its biological pattern when involving liver and spleen is not well understood due to the rarity of its occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A case of malignant fibrous histiocytoma of the liver and spleen as multiple cystic lesions in a 30 years old man is reported. The patient presented with hepatosplenomegaly resulting in central abdominal distention. Pre-operative investigations pointed toward the diagnosis of malignant cystic disease. The tumor presented as multiple hepatic cysts with massive hepatomegaly and splenomegaly. These cysts contained hemorrhagic fluid. Biopsy revealed highly cellular pleomorphic spindle cells fascicles arranged in storiform pattern at places with frequent mitoses. Immunohistochemistry revealed viamentin positivity. The tumor is compared with previous case reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Malignant fibrous histiocytoma of liver and spleen has been mentioned in the literature as isolated case reports and most of these present as solid lesions but presentation as multiple cysts is also a possibility as was seen in this patient. It can be confirmed only on histo-pathology supported by immunohistochemistry. The disease carries guarded prognosis due to its rapid progression and diagnostic dilemma pre-operatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>This rare malignancy affecting the viscera can be diagnosed only with high index of suspicion and awareness regarding its presentation can help surgeons deal with it.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2012.11.004","type":"journal-article","created":{"date-parts":[[2012,11,10]],"date-time":"2012-11-10T17:03:59Z","timestamp":1352567039000},"page":"139-141","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["A rare presentation of hepatic and splenic cystic malignant fibrous histiocytoma"],"prefix":"10.1097","volume":"4","author":[{"given":"Anupam","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh G.","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheer Singh","family":"Kalwaniya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-40-20260114","first-page":"963","article-title":"Malignant fibrous histiocytoma of the spleen accompanying hepatic cyst: report of a case and review of literature","volume":"16","author":"Feng","year":"2011","journal-title":"Journal of Research in Medical Sciences"},{"key":"R2-40-20260114","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2559.1987.tb02647.x","article-title":"Primary malignant fibrous histiocytoma of the liver: a case report with immunocytochemical observations","volume":"11","author":"Arends","year":"1987","journal-title":"Histopathology"},{"key":"R3-40-20260114","first-page":"813","article-title":"Malignant fibrous histiocytoma of the liver: a case report","volume":"80","author":"Conran","year":"1985","journal-title":"American Journal of Gastroenterology"},{"key":"R4-40-20260114","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00000478-198204000-00005","article-title":"Primary nonlymphoreticular malignant neoplasms of the spleen","volume":"6","author":"Wick","year":"1982","journal-title":"American Journal of Surgical Pathology"},{"key":"R5-40-20260114","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF01889085","article-title":"Extraretroperitoneal abdominal malignant fibrous histiocytoma","volume":"13","author":"Bruneton","year":"1988","journal-title":"Gastrointestinal Radiology"},{"key":"R6-40-20260114","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1385\/MO:18:4:293","article-title":"Primary malignant fibrous histiocytoma of the spleen and liver","volume":"18","author":"Colovic","year":"2001","journal-title":"Medical Oncology"},{"key":"R7-40-20260114","first-page":"390","article-title":"Primary malignant fibrous histiocytoma of the spleen and liver \u2013 a case report","volume":"22","author":"Lieu","year":"1993","journal-title":"Annals of the Academy of Medicine, Singapore"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212002052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261212002052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304010-00040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:24:20Z","timestamp":1768397060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304010-00040"}},"subtitle":["A case report and literature review"],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2012.11.004","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}