{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:17:27Z","timestamp":1768436247887,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Anaplastic carcinoma of the thyroid is a rare but aggressive malignancy which can present with a rapidly enlarging neck mass or compressive sequelae of cough, dyspnoea, dysphagia and hoarseness. Treatment of such tumours is commonly palliative however they occasionally represent surgical challenges due to their rapid growth, diagnostic difficulty and locoregional spread.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A 75 year-old retired veterinary surgeon was referred with a 2 month history of a painless, enlarging neck mass. The patient denied any secondary compressive symptoms or general symptoms of malignancy. On examination a large right-sided neck mass measuring 7 cm \u00d7 5 cm was appreciated which was fixed, hard and irregular with associated adenopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>We discuss the diagnostic challenges posed by anaplastic carcinoma of the thyroid and the difficulties in selecting the appropriate intervention in this aggressive disease process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Anaplastic carcinoma of the thyroid is encountered infrequently in clinical practice and can generate diagnostic and therapeutic challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2012.12.012","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T19:01:33Z","timestamp":1358449293000},"page":"378-381","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Enlarging neck masses in the elderly \u2013 Histological and surgical considerations"],"prefix":"10.1097","volume":"4","author":[{"given":"M.D.","family":"O\u2019Sullivan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.S.","family":"McAnena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.S.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"McCann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Kerin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-7-20260114","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/cncr.20936","article-title":"Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors","volume":"103","author":"Kebebew","year":"2005","journal-title":"Cancer"},{"key":"R2-7-20260114","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0140-6736(03)12488-9","article-title":"Thyroid carcinoma","volume":"361","author":"Sherman","year":"2003","journal-title":"Lancet"},{"key":"R3-7-20260114","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MOO.0b013e328343af3d","article-title":"Anaplastic thyroid carcinoma: palliation or treatment?","volume":"19","author":"Wein","year":"2011","journal-title":"Current Opinion in Otolaryngology and Head and Neck Surgery"},{"key":"R5-7-20260114","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1015-9584(09)60008-7","article-title":"Investigation of the validity of UICC stage grouping of anaplastic carcinoma of the thyroid","volume":"32","author":"Ito","year":"2009","journal-title":"Asian Journal of Surgery"},{"key":"R6-7-20260114","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1067\/msy.2001.118266","article-title":"Anaplastic thyroid carcinoma: a 50-year experience at a single institution","volume":"130","author":"McIver","year":"2001","journal-title":"Surgery"},{"key":"R7-7-20260114","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/1097-0142(20010615)91:12<2335::AID-CNCR1266>3.0.CO;2-1","article-title":"Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival","volume":"91","author":"Haigh","year":"2001","journal-title":"Cancer"},{"key":"R9-7-20260114","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jso.20700","article-title":"Pathology and genetics of thyroid carcinoma","volume":"94","author":"DeLellis","year":"2006","journal-title":"Journal of Surgical Oncology"},{"key":"R10-7-20260114","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1210\/jcem.83.7.4984","article-title":"Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells","volume":"83","author":"Blagosklonny","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"R11-7-20260114","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00423-006-0115-8","article-title":"New trends in the treatment of undifferentiated carcinomas of the thyroid","volume":"392","author":"Miccoli","year":"2007","journal-title":"Langenbeck\u2019s Archives of Surgery"},{"key":"R12-7-20260114","first-page":"1743","article-title":"Survival of a patient with anaplastic thyroid cancer following intensity-modulated radiotherapy and sunitinib\u2014a case report","volume":"32","author":"Schoenfeld","year":"2012","journal-title":"Anticancer Research"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213000102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213000102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304040-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:46:11Z","timestamp":1768398371000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304040-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2012.12.012","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}