{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:01:04Z","timestamp":1782903664328,"version":"3.54.5"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Cylindromas are usually benign tumors as small, solitary, slow-growing nodules of the scalp, face and trunk. Multiple cylindromas may form a \u201cturban tumors\u201d in the autosomal dominant Brooke-Spiegler syndrome. Malignant dermal cylindromas are very rare. There are few cases of malignant transformation of dermal cylindromas in the literature. We present an unusual case of malign cylindroma of the scalp with multiple metastasis to cervical lymph nodules and also this case is the only case that has the most lymph node metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A 52-year-old man initially presented to our clinic with hyperemic plaque located on his scalp. Measures of the plaque was 20 cm \u00d7 10 cm with bilateral, multiple palpable submandibulary lymph nodes. Entire scalp was removed reaching in depth the periostal level and bilateral modified radical neck dissection was performed. The histopathological examination of the scalp specimen was malignant skin ecrine tumor, cylindroma and on the neck dissection specimen, 55 lymph nodes were reported as metastatic out of 79. The patient was treated with chemotherapy and radiotherapy. No recurrence or metastasis was observed during a 5 year follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Malign cylindroma of the scalp rarely presents with multiple cervical lymph node metastasis, however it is important to be aware of this possibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The case reported below is outstanding in literature for being the only case that has the most lymph node metastasis. Although malign transformation of dermal cylindromas is rare, aggressive surgery should be considered with locoregional metastasis of the tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2013.02.027","type":"journal-article","created":{"date-parts":[[2013,4,19]],"date-time":"2013-04-19T09:45:41Z","timestamp":1366364741000},"page":"589-592","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Malign cylindroma of the scalp with multiple cervical lymph node metastasis\u2014A case report"],"prefix":"10.1097","volume":"4","author":[{"given":"Gokhan Giray","family":"Akgul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdinc","family":"Yenidogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soykan","family":"Dinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isin","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Kadri","family":"Colakoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Gulcelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20260114","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1365-2133.2001.04460.x","article-title":"Malignant transformation of multiple dermal cylindromas","volume":"145","author":"Durani","year":"2001","journal-title":"British Journal of Dermatology"},{"key":"R2-9-20260114","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12105-009-0138-x","article-title":"Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report","volume":"3","author":"Kuklani","year":"2009","journal-title":"Head and Neck Pathology"},{"key":"R3-9-20260114","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/1097-0142(19930901)72:5<1618::AID-CNCR2820720521>3.0.CO;2-5","article-title":"Cutaneous cylindroma with malignant transformation","volume":"72","author":"Gerretsen","year":"1993","journal-title":"Cancer"},{"key":"R5-9-20260114","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF01826771","article-title":"Weitere Beitrage zur Kenntnis der sogenannten. Zylindrome der Kopfhaut","volume":"159","author":"Wiedemann","year":"1929","journal-title":"Archives of Dermatology"},{"key":"R6-9-20260114","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5070\/D34FJ5P51C","article-title":"Brooke-Spiegler syndrome","volume":"13","author":"Kim","year":"2007","journal-title":"Dermatology Online Journal"},{"key":"R7-9-20260114","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/ajcp\/35.6.504","article-title":"Dermal cylindroma (dermal eccrine cylindroma)","volume":"35","author":"Crain","year":"1961","journal-title":"American Journal of Clinical Pathology"},{"key":"R8-9-20260114","first-page":"765","article-title":"Malignant transformation in a solitary dermal cylindroma","volume":"111","author":"Lin","year":"1987","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"R9-9-20260114","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-4362.1992.tb03985.x","article-title":"Multiple dermal cylindroma undergoing a malignant transformation","volume":"31","author":"Lotem","year":"1992","journal-title":"International Journal of Dermatology"},{"key":"R10-9-20260114","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1524-4725.1999.08138.x","article-title":"Giant malignant eccrine spiradenoma of the scalp","volume":"25","author":"Jamshidi","year":"1999","journal-title":"Dermatologic Surgery"},{"key":"R11-9-20260114","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1524-4725.1995.tb00281.x","article-title":"An unusual case of early malignant transformation in a spiradenoma","volume":"21","author":"Herzberg","year":"1995","journal-title":"Dermatologic Surgery"},{"key":"R12-9-20260114","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00000372-199812000-00005","article-title":"Primary cutaneous adenoid cystic carcinoma with lymph node metastasis","volume":"20","author":"Kato","year":"1998","journal-title":"American Journal of Dermatopathology"},{"key":"R13-9-20260114","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/00313028909061072","article-title":"Malignant dermal cylindromas: do they exist? A morphological and immunohistochemical study and review of the literature","volume":"21","author":"Iyer","year":"1989","journal-title":"Pathology"},{"key":"R14-9-20260114","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00000637-199002000-00013","article-title":"Malignant degeneration of dermal cylindroma","volume":"24","author":"Hammond","year":"1990","journal-title":"Annals of Plastic Surgery"},{"key":"R15-9-20260114","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0190-9622(99)70454-8","article-title":"Primary adenoid cystic carcinoma of skin with lung metastasis","volume":"40","author":"Chang","year":"1999","journal-title":"Journal of the American Academy of Dermatology"},{"key":"R16-9-20260114","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/(SICI)1097-0347(200001)22:1<84::AID-HED12>3.0.CO;2-7","article-title":"Primary cutaneous adenoid cystic carcinoma metastatic to cervical lymph nodes","volume":"22","author":"Weekly","year":"2000","journal-title":"Head and Neck"},{"key":"R17-9-20260114","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1258\/0022215011908595","article-title":"Primary cutaneous adenoid cystic carcinoma with regional lymph node metastasis","volume":"115","author":"Chu","year":"2001","journal-title":"Journal of Laryngology and Otology"},{"key":"R18-9-20260114","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1468-3083.2004.00904.x","article-title":"Primary cutaneous adenoid cystic carcinoma with lung and lymph node metastases","volume":"18","author":"Doganay","year":"2004","journal-title":"Journal of the European Academy of Dermatology and Venereology"},{"key":"R19-9-20260114","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1524-4725.1991.tb03281.x","article-title":"Malignant cylindroma of the scalp","volume":"17","author":"Lo","year":"1991","journal-title":"Journal of Dermatologic Surgery and Oncology"},{"key":"R20-9-20260114","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00000637-199602000-00017","article-title":"Transcranial erosion of a benign dermal cylindroma","volume":"36","author":"Wyld","year":"1996","journal-title":"Annals of Plastic Surgery"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213001272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213001272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304070-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:27:21Z","timestamp":1768397241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304070-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2013.02.027","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}