{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:00:11Z","timestamp":1772758811543,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":205,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Despite the fact the mucocoele of the appendix is a rare entity it has been the subject of much interest in the literature. The term mucocoele refers to cystic dilatation of the appendix filled with mucin resulting from proximal obstruction of the appendix lumen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>We report two patients presenting with mucinous cystadenoma of the appendix with elevation of serum carcinoembryonic antigen (CEA), which has rarely been reported. Both patients had mild symptoms and a normal colonoscopy preoperatively. The diagnosis was not suspected in one patient prior to surgery. The elevated CEA prompted additional diagnostic radiologic investigations including ultrasonography, and computed tomography scans. The patients had uneventful appendicectomies with subsequent normalization of their CEA levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Mucinous cystadenoma of the appendix is a rare pathological entity characterized by a dilated mucous filled appendix. The presence of an elevated CEA associated with the presence of this entity is a rare presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Because the diagnosis is rarely suspected prior to surgery patients with an enlarged appendix with associated elevated CEA levels should have careful investigations to exclude malignancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2013.07.007","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T21:45:19Z","timestamp":1375479919000},"page":"886-888","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA)"],"prefix":"10.1097","volume":"4","author":[{"given":"M.E.C.","family":"McFarlane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Plummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bonadie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-27-20260114","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/102490791101800303","article-title":"A retrospective study on mucocele of the appendix presenting with acute abdomen or acute appendicitis","volume":"18","author":"Yakan","year":"2011","journal-title":"Hong Kong Journal of Emergency Medicine"},{"key":"R2-27-20260114","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/BF02235492","article-title":"Giant mucocoele of the appendix","volume":"44","author":"Minni","year":"2001","journal-title":"Diseases of the Colon & Rectum"},{"key":"R3-27-20260114","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/BF02068082","article-title":"Appendiceal mucocoele with concomitant colonic cancer","volume":"39","author":"Fujiwara","year":"1996","journal-title":"Diseases of the Colon & Rectum"},{"key":"R4-27-20260114","first-page":"750","article-title":"Benign and malignant cystic tumors of the appendix","volume":"71","author":"Woodruff","year":"1940","journal-title":"Surgery, Gynecology and Obstetrics"},{"key":"R5-27-20260114","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/1097-0142(197312)32:6<1525::AID-CNCR2820320632>3.0.CO;2-C","article-title":"Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix: a re-evaluation of appendiceal mucocoele","volume":"32","author":"Higa","year":"1973","journal-title":"Cancer"},{"key":"R6-27-20260114","first-page":"1095","article-title":"A case of appendiceal mucocoele associated with colon cancer","volume":"50","author":"Zullo","year":"1995","journal-title":"Minerva Chirurgica"},{"key":"R7-27-20260114","first-page":"397","article-title":"Mucocele of the appendix with concomitant colonic cancer: case report","volume":"20","author":"Versaci","year":"1999","journal-title":"Giornale di Chirurgia"},{"key":"R8-27-20260114","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2169\/internalmedicine1962.29.642","article-title":"A case of primary mucinous cystadenocarcinoma of the appendix with elevated serum carcinoembryonic antigen (CEA)","volume":"29","author":"Noritake","year":"1990","journal-title":"Japanese Journal of Medicine"},{"key":"R9-27-20260114","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/jcp.50.7.613","article-title":"Mucinous cystadenoma of the appendix with raised serum carcinoembryonic antigen concentration: clinical and pathological features","volume":"50","author":"Shimizu","year":"1997","journal-title":"Journal of Clinical Pathology"},{"key":"R10-27-20260114","first-page":"41","article-title":"A case of appendiceal mucocele with elevated CEA level in the cystic fluid detected by colonoscopic examination","volume":"42","author":"Oshimo","year":"2000","journal-title":"Gastroenterological Endoscopy"},{"key":"R11-27-20260114","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0009-9260(98)80064-0","article-title":"Case report: mucocoele of the tip of the appendix","volume":"53","author":"Takahashi","year":"1998","journal-title":"Clinical Radiology"},{"key":"R12-27-20260114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/01.pap.0000194625.05137.51","article-title":"Appendiceal mucinous tumors and pseudomyxoma peritonei: histologic features, diagnostic problems, and proposed classification","volume":"12","author":"Pai","year":"2005","journal-title":"Advances in Anatomic Pathology"},{"key":"R13-27-20260114","first-page":"392","article-title":"Benign and malignant mucocoele of the appendix. Histological types and prognosis","volume":"139","author":"Aho","year":"1973","journal-title":"Acta Chirurgica Scandinavica"},{"key":"R14-27-20260114","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1148\/rg.233025134","article-title":"Primary neoplasms of the appendix: radiologic spectrum of disease with pathologic correlation","volume":"23","author":"Pickhardt","year":"2003","journal-title":"Radiographics"},{"key":"R15-27-20260114","first-page":"787","article-title":"Mucocele of the appendix: computer tomographic, endoscopic, and pathologic correlation","volume":"87","author":"Isaacs","year":"1992","journal-title":"American Journal of Gastroenterology"},{"key":"R16-27-20260114","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00004728-200305000-00001","article-title":"Rare benign and malignant appendiceal lesions: spectrum of computed tomography findings with pathologic correlation","volume":"27","author":"Chiou","year":"2003","journal-title":"Journal of Computer Assisted Tomography"},{"key":"R17-27-20260114","first-page":"259","article-title":"Appendiceal mucocoele: a case report and review of the literature","volume":"86","author":"Haritopoulos","year":"2001","journal-title":"International Surgery"},{"key":"R18-27-20260114","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0016-5107(76)73580-6","article-title":"An endoscopic view of mucocoele of the appendix","volume":"23","author":"Ponsky","year":"1976","journal-title":"Gastrointestinal Endoscopy"},{"key":"R19-27-20260114","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0016-5107(89)72860-1","article-title":"The volcano sign of appendiceal mucocoele","volume":"35","author":"Hamilton","year":"1989","journal-title":"Gastrointestinal Endoscopy"},{"key":"R20-27-20260114","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00268-006-0454-1","article-title":"Mucocele of the appendix","volume":"31","author":"Ruiz-Tovar","year":"2007","journal-title":"World Journal of Surgery"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213002216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213002216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304100-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:28:58Z","timestamp":1768397338000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304100-00027"}},"subtitle":["Report of two cases and review of the literature"],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2013.07.007","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}