{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:32:35Z","timestamp":1784824355994,"version":"3.55.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n INTRODUCTION:<\/jats:title>\n \n Abiotrophia<\/jats:italic>\n species have been referred to as nutritionally variant streptococci because of their fastidious nutritional requirements for growth.\n Abiotrophia<\/jats:italic>\n species are difficult to identify with conventional solid culture.\n <\/jats:p>\n <\/jats:sec>\n \n PRESENTATION OF CASE:<\/jats:title>\n \n A 48-year-old woman was admitted to our hospital with severe low back pain and body temperature of 38.2 \u00b0C. Magnetic resonance imaging revealed edema and contrast enhancement of the L4 and L5 vertebral bodies with high signal intensity in the L3-4 and L4-5 intervertebral discs on the T2-weighted images. The patient underwent needle biopsy of the L3-4 disk. Cultures of disk biopsy samples and blood yielded gram positive cocci in short chains with scanty growth on chocolate agar. Further subculture with supplemented medium and subsequent 16S ribosomal RNA gene sequencing identified the pathogen as\n Abiotrhophia adiacens<\/jats:italic>\n . The patient was treated with intravenous ampicillin. At 6-month follow-up, the patient was free of symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n \n Causative microorganisms remain unidentified in 25\u201340% of spinal infection cases.\n Abiotrophia<\/jats:italic>\n species grow poorly on conventional solid media, and require pyridoxal or thiol group supplementation. Use of Brucella HK agar or GAM agar plate is helpful for detection of\n Abiotrophia<\/jats:italic>\n species. We first confirmed the diagnosis by direct identification of\n Abiotrophia<\/jats:italic>\n adiacens from infected disk.\n Abiotrophia<\/jats:italic>\n species are one of the major pathogens of infective endocarditis accounting for 5% of cases. Considering their fastidious nature, it is likely that most cases of\n Abiotrophia<\/jats:italic>\n discitis are falsely classified as culture-negative discitis; therefore, their role in pyogenic discitis may be underestimated.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Subculture using nutritionally supplemented media is crucial for their identification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2013.09.018","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T20:45:31Z","timestamp":1380746731000},"page":"1107-1109","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Pyogenic discitis due to Abiotrophia adiacens"],"prefix":"10.1097","volume":"4","author":[{"given":"Kosuke","family":"Uehara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Chikuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Higurashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Ohkusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsushi","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Seichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20260114","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/CMR.4.2.184","article-title":"Nutritionally variant streptococci","volume":"4","author":"Ruoff","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"R2-16-20260114","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.blo.0000203452.36522.97","article-title":"Spinal infections: diagnostic tests and imaging studies","volume":"444","author":"An","year":"2006","journal-title":"Clin Orthop Relat Res"},{"key":"R3-16-20260114","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1302\/0301-620X.87B11.16294","article-title":"Spinal infections","volume":"87","author":"Govender","year":"2005","journal-title":"J Bone Joint Surg Br"},{"key":"R4-16-20260114","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1445-5994.1998.tb00667.x","article-title":"Vertebral osteomyelitis and discitis associated with Abiotrophia adiacens (nutritionally variant streptococcus) infection","volume":"28","author":"Heath","year":"1998","journal-title":"Aust N Z J Med"},{"key":"R5-16-20260114","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10096-004-1265-7","article-title":"First case of multiple discitis and sacroiliitis due to Abiotrophia defectiva","volume":"24","author":"Wilhelm","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R6-16-20260114","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s15010-002-2104-3","article-title":"Vertebral osteomyelitis and endocarditis of a pacemaker lead due to Granulicatella (Abiotrophia) adiacens","volume":"30","author":"Rosenthal","year":"2002","journal-title":"Infection"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213003039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261213003039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201304120-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:16:40Z","timestamp":1768396600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201304120-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":6,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2013.09.018","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}