{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:54:40Z","timestamp":1773320080383,"version":"3.50.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Primary hepatic lymphoma is a rare malignancy which misdiagnosis and mistreatment is very frequent. Differential diagnosis of the hepatic lesion, based on the noninvolvement of blood vessels, includes: fatty infiltration, cirrhosis, amyloid infiltration, primary hepatomas, and metastatic neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>We describe a case of a 69-year-old man who presented with 15% weight loss and general fatigue over the previous 9 months. Physical examination revealed hepatomegaly without lymphadenopathy or splenomegaly. Magnetic resonance imaging showed a 13 cm \u00d7 9 cm \u00d7 11 cm tumor on the right liver associated with normal levels of alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA). After two negatives ultrasonography-guided needle liver biopsies, the third one showed diffuse infiltration of large sized lymphoid cells. Immunohistochemical findings demonstrated the B-lymphocyte lineage of the tumor. The patient received R-CHOP therapy (cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab) with good response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>It is important to recognize PHL because it responds favorably to chemotherapy and may have a better prognosis than hepatocellular carcinoma or metastatic disease of the liver. When imaging findings on CT scans and MRI are nonspecific, a biopsy is needed not only for a definitive diagnosis but also for identifying the immunophenotype of the PHL. This type of lesion is highly chemosensitive and early aggressive chemotherapy may result in sustained remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>This case emphasizes the importance of effective recognition of PHL considering its good response to chemotherapy and the possibility of sustained remission if early aggressive treatment is implemented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2013.10.003","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T16:00:20Z","timestamp":1382025620000},"page":"1165-1168","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Primary hepatic lymphoma"],"prefix":"10.1097","volume":"4","author":[{"given":"Vivian","family":"Resende","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane S.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael T.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Santos","family":"Laboissi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson Campos","family":"Tavares-Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo Fl\u00e1vio","family":"de Melo Couto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-33-20260114","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1440-1746.2010.06555.x","article-title":"Hepatobiliary and pancreatic: primary hepatic lymphoma","volume":"26","author":"Gatselis","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"R2-33-20260114","first-page":"6016","article-title":"Diagnosis and surgical treatment of primary hepatic lymphoma","volume":"16","author":"Yang","year":"2010","journal-title":"World J Gastroenterol"},{"key":"R3-33-20260114","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2169\/internalmedicine.50.4686","article-title":"Primary hepatic peripheral T-cell lymphoma treated with corticosteroid","volume":"50","author":"Miyashita","year":"2011","journal-title":"Intern Med"},{"key":"R4-33-20260114","first-page":"724","article-title":"Primary hepatic lymphoma-favorable outcome with chemotherapy plus rituximab","volume":"100","author":"Serrano-Navarro","year":"2008","journal-title":"Rev Esp Enferm Dig"},{"key":"R5-33-20260114","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3747\/co.v16i4.443","article-title":"Primary non-Hodgkin lymphoma of liver","volume":"16","author":"Masood","year":"2009","journal-title":"Curr Oncol"},{"key":"R6-33-20260114","first-page":"203","article-title":"Primary hepatic diffuse large B cell lymphoma: a case report","volume":"11","author":"Ma","year":"2011","journal-title":"Hepat Mon"},{"key":"R7-33-20260114","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3960\/jslrt.47.73","article-title":"Primary hepatic follicular lymphoma: a case report and discussion of chemotherapy and favorable outcomes","volume":"47","author":"Gomyo","year":"2007","journal-title":"J Clin Exp Hematopathol"},{"key":"R8-33-20260114","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s12185-008-0153-9","article-title":"Primary hepatic marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type: case report and review of the literature","volume":"88","author":"Doi","year":"2008","journal-title":"Int J Hematol"}],"container-title":["International Journal of Surgery Case 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report"],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2013.10.003","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}