{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:16:11Z","timestamp":1792304171056,"version":"4.4.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPNSTs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2014.09.006","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T11:27:13Z","timestamp":1410866833000},"page":"793-795","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Malignant peripheral nerve sheath tumor of the vulva, an unusual differential diagnosis for vulvar mass"],"prefix":"10.1097","volume":"5","author":[{"given":"B\u00fclent","family":"\u00d6zdal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u00d6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmas","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6m\u00fcr","family":"Atao\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"G\u00fcng\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mutlu","family":"Meydanli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20260114","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6","article-title":"Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases","volume":"57","author":"Ducatman","year":"1986","journal-title":"Cancer"},{"key":"R2-5-20260114","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1245\/s10434-011-1978-7","article-title":"Malignant peripheral nerve sheath tumors (MPNST): the Mayo Clinic experience","volume":"19","author":"Stucky","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"R3-5-20260114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0748-7983(05)80073-3","article-title":"Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis","volume":"21","author":"Doorn","year":"1995","journal-title":"Eur J Surg Oncol: J Eur Soc Surg Oncol Br Assoc Surg Oncol"},{"key":"R4-5-20260114","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/neuonc\/nos287","article-title":"Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1","volume":"15","author":"Kolberg","year":"2013","journal-title":"Neuro-oncology"},{"key":"R5-5-20260114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<23::AID-AJMG6>3.0.CO;2-#","article-title":"Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis","volume":"89","author":"Woodruff","year":"1999","journal-title":"Am J Med Gen"},{"key":"R6-5-20260114","first-page":"721","article-title":"Malignant peripheral nerve sheath tumor of the vulva. A case report","volume":"47","author":"Maglione","year":"2002","journal-title":"J Reprod Med"},{"key":"R7-5-20260114","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/gyno.2002.6600","article-title":"Malignant peripheral nerve sheath tumor of the vulva: a multimodal treatment approach","volume":"85","author":"Lambrou","year":"2002","journal-title":"Gynecol Oncol"},{"key":"R8-5-20260114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3346\/jkms.1997.12.1.78","article-title":"Purely epithelioid malignant peripheral nerve sheath tumor of the vulva","volume":"12","author":"Lee","year":"1997","journal-title":"J Korean Med Sci"},{"key":"R9-5-20260114","first-page":"180","article-title":"Sarcoma of the vulva. Report of 12 patients","volume":"38","author":"DiSaia","year":"1971","journal-title":"Obstet Gynecol"},{"key":"R10-5-20260114","first-page":"969","article-title":"Malignant schwannoma of the vulva. A case report","volume":"33","author":"Terada","year":"1988","journal-title":"J Reprod Med"},{"key":"R11-5-20260114","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/jso.20971","article-title":"Malignant peripheral nerve sheath tumor: molecular pathogenesis and current management considerations","volume":"97","author":"Grobmyer","year":"2008","journal-title":"J Surg Oncol"},{"key":"R12-5-20260114","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1200\/JCO.2005.01.4886","article-title":"Pediatric malignant peripheral nerve sheath tumor: the Italian and German soft tissue sarcoma cooperative group","volume":"23","author":"Carli","year":"2005","journal-title":"J Clin Oncol: Off J Am Soc Clin Oncol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261214002144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261214002144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201405110-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:22:53Z","timestamp":1768396973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201405110-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2014.09.006","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}