{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:34:08Z","timestamp":1776764048789,"version":"3.51.2"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":253,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Peripheral Giant Cell Granuloma (PGCG) is the most common giant cell lesion found in the jaws; it originates from the connective tissue of the periosteum or from the periodontal ligament in response to local chronic irritation. Early and accurate diagnosis of these lesions allows for conservative management without compromising adjacent teeth or tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>This paper presents a case of PGCG in the esthetic zone of the upper jaw in a 23-year-old female patient. The treatment offered consisted of an excisional biopsy with immediate soft tissue grafting to prevent esthetic complications. The growing lesion has caused an interproximal spacing between the central and lateral incisors. The spacing spontaneously closed during the next six weeks after excision and no relapse occurred during postoperative follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Proper management of a PGCG lesion requires excluding other pathologies prior to planning for surgery. Correct diagnosis of such lesions is essential to optimize the treatment and prevent recurrence. Clinical examination alone may not give a correct picture, thereby requiring histopathological confirmation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Immediate soft tissue augmentation using a connective tissue graft has been suggested as a surgical solution after removal of PGCG to minimize patient discomfort and the loss of precious tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2014.09.014","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T02:50:07Z","timestamp":1411354207000},"page":"779-782","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Management of a Peripheral Giant Cell Granuloma in the esthetic area of upper jaw"],"prefix":"10.1097","volume":"5","author":[{"given":"Alaa' Z.","family":"Abu Gharbyah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-1-20260114","first-page":"232","article-title":"Peripheral giant cell granuloma: a potentially aggressive lesion in children","volume":"22","author":"Flaitz","year":"2000","journal-title":"Pediatr Dent"},{"key":"R3-1-20260114","first-page":"353","article-title":"An aggressive peripheral giant cell granuloma in a child","volume":"23","author":"Pandolfi","year":"1999","journal-title":"J Clin Pediatr Dent"},{"key":"R4-1-20260114","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0901-5027(88)80158-9","article-title":"Peripheral giant cell granuloma: clinico-pathologic study of 224 new cases and 956 reported cases","volume":"17","author":"Katsikeris","year":"1988","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R5-1-20260114","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0901-5027(88)80158-9","article-title":"Peripheral giant cell granuloma: clinicopathologic study of 224 new cases and review of 956 reported cases","volume":"17","author":"Katsikeris","year":"1988","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R6-1-20260114","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1902\/jop.1980.51.11.655","article-title":"Reactive lesions of the gingiva: a clinicopathological study of 741 cases","volume":"51","author":"Kfir","year":"1980","journal-title":"J Periodontol"},{"key":"R7-1-20260114","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1079-2104(97)90118-9","article-title":"Growth potential of peripheral giant cell granuloma","volume":"83","author":"Bodner","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-1-20260114","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0714.1972.tb02137.x","article-title":"Reactive lesions of the gingiva","volume":"1","author":"Eversole","year":"1972","journal-title":"J Oral Pathol"},{"key":"R9-1-20260114","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1601-0825.1995.tb00151.x","article-title":"Peripheral giant cell granuloma: a clinical study of 77 cases from 62 patients and literature review","volume":"1","author":"Mighell","year":"1995","journal-title":"Oral Dis"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261214002235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261214002235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201405110-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:22:13Z","timestamp":1768396933000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201405110-00001"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2014.09.014","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}