{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:07:15Z","timestamp":1768435635869,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Most cases of appendicitis associated with lymphoma reported in literature are in patients with Burkitt's or large B-cell lymphoma. Mantle cell lymphoma only makes up 4% of all lymphoma cases in the U.S. We report a case of a patient with mantle cell lymphoma presenting with acute appendicitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE<\/jats:title>\n                    <jats:p>A 75 year old male with a history of left cervical lymphadenopathy biopsied to be mantle cell lymphoma presented with right lower abdomen pain for 3 days. An outpatient CT scan revealed acute appendicitis. Laparoscopic appendectomy was performed without any complication. The histologic examination showed mantle cell lymphoma occluding the lumen of appendix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Typically, appendicitis is caused by obstruction of the lumen of appendix by fecalith or lymphoma. A previously reported case of a patient with mantle cell lymphoma who developed appendicitis received chemotherapy before appendectomy. The author could not determine how mantle cell lymphoma contributed to appendicitis because the lumen of appendix was not occluded by the lymphoma, likely from cytoreduction from chemotherapy. We have a patient with mantle cell lymphoma before the patient received chemotherapy who presented with appendicitis. The appendiceal specimen shows the lumen filled with mantle cell lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This is a rare case of mantle cell lymphoma causing obstruction of appendiceal lumen and subsequently appendicitis, unaffected by chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2014.10.068","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T14:16:57Z","timestamp":1416579417000},"page":"33-35","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Mantle cell lymphoma presenting as acute appendicitis"],"prefix":"10.1097","volume":"6","author":[{"given":"Max","family":"Chae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampath","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Cheema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-10-20260114","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMcpc1209304","article-title":"Case records of the Massachusetts General Hospital. 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A 4-year old boy with fever and abdominal pain","volume":"368","author":"Ryan","year":"2013","journal-title":"N Engl J Med"},{"key":"R2-10-20260114","first-page":"9","article-title":"Primary Burkitt's lymphoma of the appendix presenting as acute abdomen: a case report","volume":"2","author":"Khanna","year":"2008","journal-title":"J Radiol Case Rep"},{"key":"R3-10-20260114","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1746-1596-8-2","article-title":"Paediatric T-cell lymphoma of the appendix: a case report","volume":"8","author":"Matsushita","year":"2013","journal-title":"Diagn Pathol"},{"key":"R4-10-20260114","first-page":"629","article-title":"Primary appendiceal lymphoma presenting as perforated acute appendicitis","volume":"67","author":"Fu","year":"2004","journal-title":"J Chin Med Assoc"},{"key":"R5-10-20260114","first-page":"311","article-title":"A rare cause of acute appendicitis: Burkitt's lymphoma of the appendix","volume":"39","author":"Ghani","year":"1984","journal-title":"Med J Malaysia"},{"key":"R6-10-20260114","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.3748\/wjg.v19.i25.4015","article-title":"Unusual histopathological findings in appendectomy specimens from patients with suspected acute appendicitis","volume":"19","author":"Yilmaz","year":"2013","journal-title":"World J Gastroenterol"},{"key":"R7-10-20260114","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ajh.23176","article-title":"Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management","volume":"87","author":"Vose","year":"2012","journal-title":"Am J Hematol"},{"key":"R8-10-20260114","first-page":"868151","article-title":"Acute appendicitis in a man undergoing therapy for mantle cell lymphoma","volume":"2012","author":"Linden","year":"2012","journal-title":"Case Rep Hematol"},{"key":"R9-10-20260114","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1046\/j.1365-2559.1999.0669f.x","article-title":"Angiocentric lymphoma masquerading as acute appendicitis","volume":"34","author":"Huh","year":"1999","journal-title":"Histopathology"},{"key":"R10-10-20260114","first-page":"173","article-title":"Multiple lymphomatous polyposis with diffuse involvement of the gastrointestinal tract. 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