{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:43:01Z","timestamp":1781793781839,"version":"3.54.5"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sagliker described craniofacial, skeletal, neurologic and soft tissue abnormalities in patients with secondary hyperparathyroidism with end-stage chronic renal disease. This unique entity has been attributed to delay in treatment of renal insufficiency. As of 2012 sixty cases have been reported. The aim of the study is to report this entity in five patients and to propose this condition as an indication for parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report five patients. All patients had chronic renal failure (CRF) and secondary hyperparathyroidism that fulfilled the criteria for Sagliker syndrome and underwent parathyroid surgery. We collected detailed information, including clinical history, laboratory data, and old\/current photographs for comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The five patients, four women and one man mean age 21 years, had severe secondary hyperparathyroidism (mean serum preoperative PTH = 3779.6 pg\/ml, mean preoperative Ca\n                      <jats:sup>2+<\/jats:sup>\n                      = 8.83 mg\/dl and P\n                      <jats:sup>3\u2013<\/jats:sup>\n                      = 5.66 mg\/dl); maxillary and mandibular bone changes; teeth\/dental abnormalities; and soft and benign tumors in the mouth. Three had severe uglifying facial appearance. All patients underwent total parathyroidectomy without postoperative complications. After surgery mean serum PTH was 17.16 pg\/ml (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.006), P\n                      <jats:sup>3\u2212<\/jats:sup>\n                      = 3.38 mg\/dl (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0068) and Ca\n                      <jats:sup>2+<\/jats:sup>\n                      = 6.97 mg\/dl (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.345). At surgery, average height was 149.8 cm, a mean of 6 cm (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.003) less than at the beginning of CRF. Preoperative Beck Depression Inventory test mean score was 37 (severe depression); 6 months after surgery mean score was 15.8 (mild mood disturbance)(\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0001). Clinical follow-up was satisfactory with a mean follow up time of 14 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We consider that Sagliker syndrome should be added to current surgical indications for parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.01.044","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T12:40:20Z","timestamp":1422448820000},"page":"127-130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Sagliker syndrome in patients with secondary hyperparathyroidism and chronic renal failure"],"prefix":"10.1097","volume":"8","author":[{"given":"Ana Mej\u00eda","family":"Pineda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor J.","family":"Mel\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Lemus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Pe\u00f1alonzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-36-20260114","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1053\/j.jrn.2012.07.002","article-title":"Severe renal osteodystrophy in a pediatric patient with end-stage renal disease: Sagliker syndrome?","volume":"23","author":"Yavascan","year":"2013","journal-title":"J. Ren. Nutr"},{"key":"R2-36-20260114","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.semnephrol.2004.06.021","article-title":"Sagliker syndrome: uglifying human face appearance in late and severe secondary hyperparathyroidism in chronic renal failure","volume":"24","author":"Sagliker","year":"2004","journal-title":"Semin. Nephrol"},{"key":"R3-36-20260114","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"Beck","year":"1961","journal-title":"Arch. Gen. Psychiatry"},{"key":"R4-36-20260114","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.jrn.2007.10.023","article-title":"International study on Sagliker syndrome and uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic kidney disease patients","volume":"18","author":"Sagliker","year":"2008","journal-title":"J. Ren. Nutr"},{"key":"R5-36-20260114","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ncpneph0421","article-title":"Evidence-based treatment recommendations for uremic bleeding","volume":"3","author":"Hedges","year":"2007","journal-title":"Nat. Clin. Pract. Nephrol"},{"key":"R6-36-20260114","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00268-011-1392-0","article-title":"Initial parathyroid surgery in 606 patients with renal hyperparathyroidism","volume":"36","author":"Schneider","year":"2012","journal-title":"World J. Surg"},{"key":"R7-36-20260114","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1053\/j.jrn.2011.10.030","article-title":"International evaluation of unrecognizably uglifying human faces in late and severe secondary hyperparathyroidism in chronic kidney disease Sagliker syndrome. A unique catastrophic entity, cytogenetic studies for chromosomal abnormalities, calcium-sensing receptor gene and GNAS1 mutations. Striking and promising missense mutations on the GNAS1 Gene exons 1,4,10,4","volume":"22","author":"Yildiz","year":"2012","journal-title":"J. Ren. Nutr"},{"key":"R8-36-20260114","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.jrn.2006.04.018","article-title":"Neurologic manifestations in Sagliker syndrome: uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic renal failure patients","volume":"16","author":"Giray","year":"2006","journal-title":"J. Ren. Nutr"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215000553?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215000553?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201508000-00036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:37:00Z","timestamp":1768397820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201508000-00036"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":8,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2015.01.044","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}