{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:42:00Z","timestamp":1768434120223,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The most common cause of hyperthyroidism in children is graves\u2019 disease \u2013 an autoimmune disorder in which antibodies stimulate the thyrotropin receptor to signal growth thyroid gland by increasing thyroid hormone synthesis and release. It can be treated with medical therapy, radioactive iodine, or surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case<\/jats:title>\n                    <jats:p>JD was a two year old male who presented with severe diarrhea and diffuse neck enlargement. Laboratory work up was consistent with graves\u2019 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite maximal outpatient and inpatient treatment with methimazole, atenolol, prednisone, and SSKI, he suffered persistent thyrotoxicosis. He underwent near-total thyroidectomy without complication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case is notable as it may represent the youngest patient in the literature who has undergone thyroidectomy for graves\u2019 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.01.046","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T09:21:03Z","timestamp":1422609663000},"page":"131-133","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Thyroidectomy in a two-year old for graves\u2019 disease"],"prefix":"10.1097","volume":"8","author":[{"given":"Baddr A","family":"Shakhsheer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bordini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Layth","family":"Abdulrasool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymon","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-37-20260114","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0029-1211934","article-title":"Clinical aspects and treatment of juvenile graves\u2019 disease","volume":"105","author":"Perrild","year":"1997","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"R2-37-20260114","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0022-3476(77)80843-3","article-title":"Antithyroid drug therapy for toxic diffuse goiter (graves disease): thirty years experience in children and adolescents","volume":"91","author":"Barnes","year":"1977","journal-title":"J. Pediatr"},{"key":"R3-37-20260114","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1001\/archinte.1988.00380030132023","article-title":"graves\u2019 disease: influence of age on clinical findings","volume":"148","author":"Nordyke","year":"1988","journal-title":"Arch. Intern. Med"},{"key":"R4-37-20260114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3928\/0191-3913-19790301-05","article-title":"Dysthroid ophthalmopathy in children","volume":"16","author":"Young","year":"1979","journal-title":"J. Pediatr. Ophthalmol. 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Metab"},{"key":"R8-37-20260114","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1515\/JPEM.2008.21.11.1085","article-title":"Thyroid stimulating immunoglobulin is often negative in children with graves\u2019 disease","volume":"21","author":"Rahhal","year":"2008","journal-title":"J. Pediatr. Endocrinol. Metab"},{"key":"R9-37-20260114","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1210\/jc.2009-2546","article-title":"Dissimilar hepatotoxicity profiles of propylthiouracil and methimazole in children","volume":"95","author":"Rivkees","year":"2010","journal-title":"J. Clin Endocrinol. Metab"},{"key":"R10-37-20260114","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1007\/s00268-011-1238-9","article-title":"The surgical treatment of Graves\u2019 disease in children and adolescents","volume":"35","author":"Chiapponi","year":"2011","journal-title":"World J. Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215000577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215000577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201508000-00037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:37:10Z","timestamp":1768397830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201508000-00037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2015.01.046","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}