{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:56:39Z","timestamp":1768434999672,"version":"3.49.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["25462129"],"award-info":[{"award-number":["25462129"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Signet ring cell carcinoma (SRCC) of the ampulla of vater is a very rare tumor that is reported infrequently in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A 59-year-old woman visited our hospital for evaluation of elevated transaminase levels. On laboratory examination of tumor marker levels, carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19\u20139 levels were normal, and DUPAN-2 was elevated. Computed tomography (CT) confirmed a 2 cm, enhanced mass in the periampullary region, with marked common bile duct dilatation. Endoscopic retrograde cholangiopancreatography (ERCP) showed a swollen papilla of vater, with a reddish, erosive mucosa. Histological examination of biopsy samples from the ampulla of vater showed signet ring cell carcinoma (SRCC). The patient underwent radical pancreatoduodenectomy. Pathological examination showed that the SRCC had infiltrated into the duodenal muscularis propria and pancreatic parenchyma, and lymph node metastases were identified around the abdominal aorta and common hepatic artery. Based on the immunohistochemical staining patterns of the positive results for CDX2 and MUC2, the tumor cells in the present case appeared to have an intestinal type origin. The ampullary cancer was diagnosed as T3bN1M1, Stage IV according to the International Union Against Cancer TNM classification (UICC). After undergoing adjuvant chemotherapy with cisplatin\u2013gemcitabine chemotherapy for 6 months, the patient has remained disease-free in the 7 months since surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>SRCC of intestinal-type origin is associated with a favorable outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Investigation to confirm the histological origin of SRCC by immunohistochemical staining might inform the treatment strategy and identify patients with ampullary SRCC who may have a good prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.05.031","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T03:57:22Z","timestamp":1432871842000},"page":"108-111","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Signet ring cell carcinoma of the ampulla of vater"],"prefix":"10.1097","volume":"12","author":[{"given":"Masaki","family":"Wakasugi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tanemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Oshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironao","family":"Yasuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Akamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-30-20260114","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/00000658-199807000-00013","article-title":"Factors predictive of survival in ampullary carcinoma","volume":"228","author":"Howe","year":"1998","journal-title":"Ann. Surg"},{"key":"R2-30-20260114","first-page":"1071","article-title":"A signet-ring cell carcinoma of the ampulla of vater","volume":"114","author":"Gardner","year":"1990","journal-title":"Arch. Pathol. Lab. Med"},{"key":"R3-30-20260114","first-page":"561","article-title":"Signet-ring-cell carcinoma of the ampulla of vater: a case report","volume":"49","author":"Hara","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"R4-30-20260114","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0016-5107(02)70126-0","article-title":"Signet ring cell carcinoma of major papilla","volume":"56","author":"Tseng","year":"2002","journal-title":"Gastrointest. Endosc"},{"key":"R5-30-20260114","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s10595-002-2509-9","article-title":"Signet-ring cell carcinoma of the ampulla of vater: report of a case","volume":"33","author":"Eriguchi","year":"2003","journal-title":"Surg. Today"},{"key":"R6-30-20260114","first-page":"471","article-title":"Signet-ring cell carcinoma of the ampulla of vater","volume":"34","author":"Li","year":"2004","journal-title":"Ann. Clin. Lab. Sci"},{"key":"R7-30-20260114","first-page":"495","article-title":"Signet-ring cell carcinoma of the Vater\u2019s ampulla","volume":"5","author":"Ramia","year":"2004","journal-title":"JOP"},{"key":"R8-30-20260114","first-page":"793","article-title":"Signet-ring cell carcinoma of the ampulla of vater","volume":"103","author":"Fang","year":"2004","journal-title":"J. Formos. Med. Assoc"},{"key":"R9-30-20260114","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/000313480607200221","article-title":"Radical resection in signet ring carcinoma of the ampulla of vater: report of an 11-year survivor","volume":"72","author":"Bloomston","year":"2006","journal-title":"Am. Surg"},{"key":"R10-30-20260114","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1007\/s00595-007-3534-4","article-title":"Signet-ring cell carcinoma of the ampulla of vater: report of a case","volume":"37","author":"Akatsu","year":"2007","journal-title":"Surg. Today"},{"key":"R11-30-20260114","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3748\/wjg.15.888","article-title":"Signet-ring cell carcinoma of the ampulla of vater: contrast-enhanced ultrasound findings","volume":"15","author":"Gao","year":"2009","journal-title":"World J. Gastroenterol"},{"key":"R12-30-20260114","first-page":"690","article-title":"Signet ring cell carcinoma of the ampulla of vater: a case report","volume":"10","author":"Ishibashi","year":"2009","journal-title":"JOP"},{"key":"R13-30-20260114","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/MPA.0b013e318216db94","article-title":"Signet ring cell carcinoma of the ampulla of vater: demonstration of pancreatobiliary origin","volume":"40","author":"Gheza","year":"2011","journal-title":"Pancreas"},{"key":"R14-30-20260114","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.1200\/JCO.2011.35.2385","article-title":"Signet ring cell carcinoma of the ampulla of vater with leptomeningeal metastases: a case report","volume":"29","author":"Paplomata","year":"2011","journal-title":"J. Clin. Oncol"},{"key":"R15-30-20260114","first-page":"162","article-title":"Signet-ring cell carcinoma co-existing with adenocarcinoma of the ampulla of vater a case report","volume":"12","author":"Maekawa","year":"2011","journal-title":"JOP"},{"key":"R16-30-20260114","doi-asserted-by":"crossref","first-page":"501","DOI":"10.4321\/S1130-01082012000900013","article-title":"Signet ring cell adenocarcinoma of the ampulla of vater: a rare pathology","volume":"104","author":"Lesquereux-Mart\u00ednez","year":"2012","journal-title":"Rev. Esp. Enferm. Dig"},{"key":"R17-30-20260114","first-page":"1","article-title":"Signet ring cell carcinoma of the vater's ampulla: a very rare malignancy","volume":"2012","author":"Daoudi","year":"2012","journal-title":"Case Rep. Oncol. Med"},{"key":"R18-30-20260114","first-page":"190","article-title":"Poorly-differentiated signet-ring cell carcinoma of the ampulla of vater: report of a rare malignancy","volume":"14","author":"Acharya","year":"2013","journal-title":"JOP"},{"key":"R19-30-20260114","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3892\/ol.2014.2344","article-title":"Signet ring cell carcinoma of the ampulla of vater: immunophenotype and differentiation","volume":"8","author":"Wen","year":"2014","journal-title":"Oncol. Lett"},{"key":"R20-30-20260114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000197027","article-title":"Heterotopic gastric mucosa in the duodenum","volume":"3","author":"Hoedemaeker","year":"1970","journal-title":"Digestion"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215002527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215002527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201512000-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:29:21Z","timestamp":1768397361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201512000-00030"}},"subtitle":["Report of a case and a review of the literature"],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":20,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2015.05.031","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}