{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:40:36Z","timestamp":1783942836970,"version":"3.55.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":257,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Giant cell granuloma (GCG) is a non-neoplastic osseous proliferative lesion of unknown etiology. Although a benign disease process, GCG can be locally destructive. It is extremely rare to have a pediatric case of GCG occurring in the nasal cavity with intracranial invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>We report a case of an aggressive and recurrent giant cell granuloma with intracranial invasion in a 10 years old female patient which was completely excised with endoscopic craniofacial resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>A literature review on pathogenesis, diagnosis and management is also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The most common treatment for giant cell granuloma is surgery, ranging from simple curettage to resection. However, it must be completely excised in cases of aggressive and extensive lesion because of the high recurrence rate after incomplete removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.09.011","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T19:16:37Z","timestamp":1442603797000},"page":"67-70","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Pediatric aggressive giant cell granuloma of nasal cavity"],"prefix":"10.1097","volume":"16","author":[{"given":"Sung Tae","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Ryun","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Sang","family":"Rha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20260114","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00381-013-2254-x","article-title":"Giant cell reparative granuloma of the pediatric cranium: case report and review of the literature","volume":"30","author":"Conley","year":"2014","journal-title":"Childs Nerv. Syst"},{"key":"R2-17-20260114","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hed.20069","article-title":"Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990\u20131995","volume":"26","author":"de Lange","year":"2004","journal-title":"Head Neck"},{"key":"R3-17-20260114","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0030-4220(53)90151-0","article-title":"Giant-cell reparative granuloma traumatic bone cyst, and fibrous (fibro-oseous) dysplasia of the jawbones","volume":"6","author":"Jaffe","year":"1953","journal-title":"Oral Surg. Oral Med. Oral Pathol"},{"key":"R4-17-20260114","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11845-012-0858-x","article-title":"Aggressive giant cell granuloma of the jaws treated with interferon alpha: a report of two cases","volume":"182","author":"O'Connell","year":"2013","journal-title":"Ir. J. Med. Sci"},{"key":"R5-17-20260114","first-page":"690194","article-title":"Aggressive giant cell reparative granuloma of the nasal cavity","volume":"2013","author":"Ishinaga","year":"2013","journal-title":"Case Rep. Otolaryngol"},{"key":"R6-17-20260114","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0278-2391(86)90040-6","article-title":"Central giant cell lesions of the jaws: a clinicopathologic study","volume":"44","author":"Chuong","year":"1986","journal-title":"J. Oral Maxillofac. Surg"},{"key":"R7-17-20260114","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0165-5876(02)00348-8","article-title":"Giant cell reparative granulo a originating from the ethmoid sinus","volume":"67","author":"Arda","year":"2003","journal-title":"Int. J. Pediatr. Otorhinolaryngol"},{"key":"R8-17-20260114","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0022215100130701","article-title":"Giant cell reparative granuloma of the concha bullosa","volume":"109","author":"Koay","year":"1995","journal-title":"J. Laryngol. Otol"},{"key":"R9-17-20260114","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0046-8177(74)80064-X","article-title":"Giant cell reparative granuloma outside the jaw bone: diagnostic criteria and review of the literature with the first case described in the temporal bone","volume":"5","author":"Hirschl","year":"1974","journal-title":"Hum. Pathol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215004022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215004022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201516000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:21:36Z","timestamp":1768396896000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201516000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":9,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2015.09.011","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}