{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:33:47Z","timestamp":1768440827385,"version":"3.49.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Cavernous hemangioma of the adrenal gland is a rare benign tumor. The diagnosis is often postoperative on histological exam with the presence of blood-filled, dilated vascular spaces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>We report the clinical case of a 49 years-old woman who came to our observation with aspecific abdominal pain. A computed tomography (CT) abdominal scan revealed a 11 cm right adrenal mass. This lesion was well circumscribed, round, encapsulated. After iodinated-contrast we observed a progressive, inhomogeneous enhancement without evidence of active bleeding and with pre-operative diagnosis of adrenal hemangioma. Laparoscopic adrenalectomy was performed by a transperitoneal flank approach. Pathological examination revealed a 11 cm adrenal mass with extensive central necrotic areas mixed to sinusoidal dilation and fibrotic septa. Postoperative diagnosis was adrenal hemangioma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Adrenal hemangiomas occur infrequently. Generally these adrenal masses are non-functioning and there is no specific symptoms. Recent records demonstrate that laparoscopic adrenalectomy is technically safe and feasible for large adrenal tumors, but controversy exists in cases of suspected malignancy. We choose laparoscopic approach to adrenal gland on the basis of preoperative CT abdominal scan that excludes radiological signs of adrenocortical carcinoma (ACC) such as peri-adrenal infiltration and vascular invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Laparoscopic adrenalectomy is considered the standard treatment in case of diagnosis of benign lesions. In this case report we discussed a large adrenal cavernous hemangioma treated with laparoscopic approach. Fundamental is the study of preoperative endocrine disorders and radiologic findings to exclude signs of malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.09.040","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T20:34:21Z","timestamp":1445200461000},"page":"150-153","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Large cavernous hemangioma of the adrenal gland"],"prefix":"10.1097","volume":"16","author":[{"given":"A.","family":"Agrusa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Salamone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Buono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chianetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sorce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gulotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Galia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gulotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-38-20260114","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0022-5347(17)67320-8","article-title":"Hemangioma of the adrenal","volume":"74","author":"Johnson","year":"1955","journal-title":"J. Urol"},{"key":"R2-38-20260114","first-page":"242","article-title":"Cardiac risk stratification in elective non-cardiac surgery: role of NT-proBNP","volume":"30","author":"Novo","year":"2011","journal-title":"Int. Angiol"},{"key":"R3-38-20260114","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.urology.2013.04.005","article-title":"Giant adrenal cavernous hemangioma: a rare abdominal mass","volume":"82","author":"Galea","year":"2013","journal-title":"Urology"},{"key":"R4-38-20260114","first-page":"125","article-title":"Laparoscopic management of adrenal tumors: a four-year experience in a single center","volume":"69","author":"Romano","year":"2014","journal-title":"Minerva Chirurgica"},{"key":"R5-38-20260114","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijscr.2013.12.020","article-title":"Adrenal gunshot wound: Laparoscopic approach. Report of a case","volume":"5","author":"Agrusa","year":"2014","journal-title":"Int. J. Surg. 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Case report and literature review","volume":"12","author":"Benassai","year":"2014","journal-title":"Int. J. Surg"},{"key":"R13-38-20260114","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijscr.2013.11.003","article-title":"A rare cavernous hemangioma of the adrenal gland","volume":"5","author":"Edwards","year":"2014","journal-title":"Int. J. Surg. Case Rep"},{"key":"R14-38-20260114","first-page":"78","article-title":"Retroperitoneal hemorrhage secondary to a ruptured cavernous hemangioma","volume":"48","author":"Forbes","year":"2005","journal-title":"Can. J. Surg"},{"key":"R15-38-20260114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1749-7922-9-33","article-title":"Right diaphragmatic injury and lacerated liver during a penetrating abdominal trauma: case report and brief literature review","volume":"25","author":"Agrusa","year":"2014","journal-title":"World J. Emerg. 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