{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:54:31Z","timestamp":1780487671611,"version":"3.54.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n INTRODUCTION:<\/jats:title>\n Clear cell renal cell carcinoma (ccRCC) is well known for its propensity to metastasize to unusual sites, even after 10 years. Gallbladder metastases are extremely rare, being found in approximately 0.6% of cases, at autopsy.<\/jats:p>\n <\/jats:sec>\n \n CASE PRESENTATION:<\/jats:title>\n A 51-year-old man with a history of right ccRCC underwent total nephrectomy with extended lymphadenectomy, in another Hospital. Three years later, he was hospitalized at our Hospital, with gallbladder metastasis detected during a follow-up CT scan. At clinical examination, the patient did not present any symptoms or signs of gallbladder disease. Several imaging tests were performed to better characterize the lesion. A successful cholecystectomy and hepatic resection of 4b segment were performed, obtaining a R0 resection. The clinical course was uneventful, without any complications. After a 7-month follow-up, the patient is free from disease.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n A typical metastases are those located in a site other than thoracic, skeletal, hepatic, adrenal or encephalic tissue. Cholecystectomy with R0 resection has demonstrated to be the only factor increasing survival, mainly in isolated cases of metastasis, providing an overall 35\u201360% survival rate at 5 years.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n In the follow-up of patients with a positive history of renal cell carcinoma specially clear cell subtype, all new finding should be taken into account as possible metastases. We ought to consider US and CT-scan behavior of gallbladder metastatic disease in order to orientate our diagnosis. Surgery for metastatic gallbladder disease of renal origin seems to be a feasible therapy which is capable of increasing patients\u2019 overall survival.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2015.11.021","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T13:18:04Z","timestamp":1448630284000},"page":"48-51","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Gallbladder\u2019s clear cell renal carcinoma metastasis"],"prefix":"10.1097","volume":"18","author":[{"given":"Carolina Castro","family":"Ruiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pedrazzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-14-20260114","doi-asserted-by":"crossref","first-page":"e37366","DOI":"10.1371\/journal.pone.0037366","article-title":"MicroRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion","volume":"7","author":"Dey","year":"2012","journal-title":"PLoS One"},{"key":"R3-14-20260114","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00534-007-1226-5","article-title":"Renal cell carcinoma with unusual metastasis to the gallbladder","volume":"15","author":"Nojima","year":"2008","journal-title":"J. Hepatobiliary Pancreat. Surg"},{"key":"R4-14-20260114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijscr.2015.03.009","article-title":"A unique presentation of a renal clear cell carcinoma with atypical metastases","volume":"11","author":"Staderini","year":"2015","journal-title":"Int. J. Surg. Case Rep"},{"key":"R5-14-20260114","doi-asserted-by":"crossref","first-page":"E559","DOI":"10.1111\/j.1464-410X.2012.11271.x","article-title":"Surgical treatment of atypical metastasis from renal cell carcinoma (RCC)","volume":"110","author":"Antonelli","year":"2012","journal-title":"BJU Int"},{"key":"R6-14-20260114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1746-1596-8-4","article-title":"A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature","volume":"8","author":"Ghaouti","year":"2013","journal-title":"Diagn. Pathol"},{"key":"R7-14-20260114","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2463\/mrms.2013-0130","article-title":"Gallbladder metastasis from renal cell carcinoma: a case report with review of the literature","volume":"14","author":"Ueda","year":"2015","journal-title":"Magn. Reson. Med. Sci"},{"key":"R9-14-20260114","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.3748\/wjg.15.4806","article-title":"Metastasis to the gallbladder: a single-center experience of 20 cases in South Korea","volume":"38","author":"Jae Yoon","year":"2009","journal-title":"World J. Gastroenterol"},{"key":"R10-14-20260114","first-page":"184","article-title":"M etastasi singola colecistica di neoplasia renale a cellule chiare","volume":"30","author":"Biolchini","year":"2009","journal-title":"Suppl. G. Chir"},{"key":"R11-14-20260114","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.3892\/ol.2012.616","article-title":"Metastasis of the gallbladder in clear cell renal carcinoma","volume":"3","author":"Bosc\u00e0 Robledo","year":"2012","journal-title":"Oncol. Lett"},{"key":"R12-14-20260114","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0090-4295(99)80310-0","article-title":"Renal cell carcinoma metastatic to the gallbladder or prostate: two case reports","volume":"46","author":"King","year":"1995","journal-title":"Urology"},{"key":"R13-14-20260114","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3348\/kjr.2014.15.3.334","article-title":"CT findings of gallbladder metastasese: emphasis on differences according to primary tumors","volume":"15","author":"Choi","year":"2014","journal-title":"Korean J. Radiol"},{"key":"R14-14-20260114","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/cncr.11234","article-title":"Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma. A stratification tool for prospective clinical trials","volume":"97","author":"Leibovich","year":"2013","journal-title":"Cancer"},{"key":"R15-14-20260114","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.anorl.2010.11.003","article-title":"Clear-cell renal carcinoma metastasis to the base of the toungue and sphenoid sinus: two very rare atypical ENT locations","volume":"128","author":"Morvan","year":"2011","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis"},{"key":"R16-14-20260114","first-page":"482","article-title":"Renal cell carcinoma metastasis to the gallbladder detected by FDG-PET\/CT","volume":"6","author":"Win","year":"2014","journal-title":"J. Clin. Med. Res"},{"key":"R17-14-20260114","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7863\/jum.1996.15.10.725","article-title":"Color doppler ultrasonographic evaluation of renal cell carcinoma metastasis to the gallbladder","volume":"15","author":"Lombardo","year":"1996","journal-title":"J. Ultrasound Med"},{"key":"R19-14-20260114","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.5858\/2009-0453-OA.1","article-title":"Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polyp","volume":"134","author":"Fang","year":"2010","journal-title":"Arch. Pathol. Lab. Med"},{"key":"R20-14-20260114","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00345-013-1060-0","article-title":"The role of surgery for metastatic renal cell carcinoma in the era of targeted therapies","volume":"31","author":"Bigot","year":"2013","journal-title":"World J. Urol"},{"key":"R21-14-20260114","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02303572","article-title":"Surgeon\u2019s role in the management of solitary renal cell carcinoma metastases occurring subsequentt to initial curative nephrectomy: an institutional review","volume":"1","author":"Kiemey","year":"1994","journal-title":"Ann. Surg. Oncol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215005015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261215005015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201618000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:27:01Z","timestamp":1768397221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201618000-00014"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":18,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2015.11.021","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}