{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:45:57Z","timestamp":1768434357255,"version":"3.49.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T00:00:00Z","timestamp":1462320000000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Congenital factor VII deficiency is a rare bleeding disorder with high phenotypic variability. It is critical that children with congenital Factor VII deficiency be identified early when high-risk surgery is planned. Cranial vault surgery is common for children with craniosynostosis, and these surgeries are associated with significant morbidity mostly secondary to the risk of massive blood loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A two-month old infant who presented for elective craniosynostosis repair was noted to have an elevated prothrombin time (PT) with a normal activated partial thromboplastin time (aPTT) on preoperative labs. The infant had no clinical history or reported family history of bleeding disorders, therefore a multidisciplinary decision was made to repeat the labs under general anesthesia and await the results prior to incision. The results confirmed the abnormal PT and the case was canceled. Hematologic workup during admission revealed factor VII deficiency. The patient underwent an uneventful endoscopic strip craniectomy with perioperative administration of recombinant Factor VIIa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Important considerations for perioperative laboratory evaluation and management in children with factor VII deficiency are discussed. Anesthetic and surgical management of the child with factor VII deficiency necessitates meticulous planning to prevent life threatening bleeding during the perioperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>A thorough history and physical examination with a high clinical suspicion are vital in preventing hemorrhage during surgeries in children with coagulopathies. Abnormal preoperative lab values should always be confirmed and addressed before proceeding with high-risk surgery. A multidisciplinary discussion is essential to optimize the risk-benefit ratio during the perioperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T19:35:08Z","timestamp":1462649708000},"page":"77-79","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Elevated prothrombin time on routine preoperative laboratory results in a healthy infant undergoing craniosynostosis repair"],"prefix":"10.1097","volume":"24","author":[{"given":"Kareen L.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward S.","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna R.","family":"Kudchadkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-21-20260114","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1160\/TH04-10-0650","article-title":"Clinical phenotypes and factor VII genotype in congenital factor VII deficiency","volume":"93","author":"Mariani","year":"2005","journal-title":"Thromb. Haemost"},{"key":"R2-21-20260114","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1365-2516.2008.01844.x","article-title":"Factor VII deficiency: defining the clinical picture and optimizing therapeutic options","volume":"14","author":"Lapecorella","year":"2008","journal-title":"Haemophilia"},{"key":"R3-21-20260114","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/hae.12160","article-title":"Use of global assays to understand clinical phenotype in congenital factor VII deficiency","volume":"19","author":"Greene","year":"2013","journal-title":"Haemophilia"},{"key":"R4-21-20260114","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.anclin.2007.05.008","article-title":"Perioperative management of pediatric patients with craniosynostosis","volume":"25","author":"Koh","year":"2007","journal-title":"Anesthesiol. 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Haemost"},{"key":"R9-21-20260114","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-2516.2011.02596.x","article-title":"rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency","volume":"17","author":"Tran","year":"2011","journal-title":"Haemophilia"},{"key":"R10-21-20260114","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3324\/haematol.2012.074039","article-title":"Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety: results from the Seven Treatment Evaluation Registry (STER)","volume":"98","author":"Napolitano","year":"2013","journal-title":"Haematologica"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261216301250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261216301250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201624000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:40:29Z","timestamp":1768398029000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201624000-00021"}},"subtitle":["Diagnosis and perioperative management of congenital factor VII deficiency"],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":10,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2016.05.004","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}