{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:00:07Z","timestamp":1768438807412,"version":"3.49.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":311,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Patients with type 1 Gaucher disease have been reported to be more likely to have cholelithiasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A case of cholelithiasis in a patient with type 1 Gaucher disease; which is very intriguing to show this comorbidity. The case was the only known case with this pathology in time of diagnosis in our country (Kosovo). The patient is a 21-year old girl a known case of type 1 Gaucher disease, at the age of 8 years. The patient underwent elective laparoscopic cholecystectomy. Chronic inflammatory changes and adhesions were obvious during surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Type 1 Gaucher disease patients have several risk factors for gallstone formation: increased biliary excretion of glucosylceramide, advanced liver disease and cirrhosis, splenomegaly, inborn error of metabolism, chronic systemic inflammation, T cell dysfunction, and insulin resistance\u201d to risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Gallstones and cholecystitis should be considered when abdominal symptoms and liver dysfunctions are seen in these patients. More studies are needed in especially Kosovo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2016.11.008","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T03:30:39Z","timestamp":1478835039000},"page":"227-229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Case report of cholelithiasis in a patient with type 1 Gaucher disease"],"prefix":"10.1097","volume":"29","author":[{"given":"Afrim","family":"Avdaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naim","family":"Fanaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirsade","family":"Osmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agron","family":"Bytyqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anila","family":"Cake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-58-20260114","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0006-291X(65)90743-6","article-title":"Metabolism of glucocerebrosides II. Evidence of an enzymatic deficiency in Gaucher\u2019s disease","volume":"18","author":"Brady","year":"1965","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"R2-58-20260114","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency \u2212macrophage \u2212targeted glucocerebrosidase for Gaucher\u2019s disease","volume":"324","author":"Barton","year":"1991","journal-title":"N. Engl. J. Med"},{"key":"R3-58-20260114","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/bcmd.2001.0480","article-title":"Cholelithiasis in patients with Gaucher disease","volume":"28","author":"Rosenbaum","year":"2002","journal-title":"Blood Cells Mol. Dis"},{"key":"R4-58-20260114","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/00004836-200408000-00009","article-title":"Increased prevalence of cholelithiasis in Gaucher disease: association with splenectomy but not with Gilbert syndrome","volume":"38","author":"Ben Harosh-Katz","year":"2004","journal-title":"J. Clin. Gastroenterol"},{"key":"R5-58-20260114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10545-010-9070-1","article-title":"High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease","volume":"33","author":"Taddei","year":"2010","journal-title":"J. Inherit. Metab. Dis"},{"key":"R6-58-20260114","first-page":"632","article-title":"Management of gallstones","volume":"72","author":"Bellows","year":"2005","journal-title":"Am. Fam. Phys"},{"key":"R7-58-20260114","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0005-2760(81)90279-4","article-title":"Biliary excretion of glycolipid in induced or inherited glucosylceramide lipiosis","volume":"665","author":"Pentchel","year":"1981","journal-title":"Biochim. Biophys. Acta"},{"key":"R8-58-20260114","first-page":"330","article-title":"Prevalence and incidence of cholelithiasis in patients with liver cirrhosis","volume":"29","author":"Maggi","year":"1997","journal-title":"Ital. J. Gastroenterol. Hepatol"},{"key":"R9-58-20260114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10545-010-9070-1","article-title":"High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease","volume":"33","author":"Taddei","year":"2010","journal-title":"J. Inherit. Metab. Dis"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261216304862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261216304862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201629000-00058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:51:15Z","timestamp":1768398675000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201629000-00058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":9,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2016.11.008","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}