{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:35:38Z","timestamp":1791660938821,"version":"4.3.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Bronchial localization of Mucoepidermoid carcinoma (MEC) is rare. The precise nature of these neoplasms is not yet clear and little is known on the histogenesis and pathogenesis of the disease. Here we present a case of a bronchial MEC with a detailed pathological, immunohistochemical, and molecular analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF A CASE:<\/jats:title>\n                    <jats:p>A 46 years old Caucasian male patient was referred to our Unit for fever, non productive cough and dyspnea lasting for two months. The chest CT scan evidenced an 8-mm intraluminal lesion in the left main bronchus, in correspondence of the origin of the lingular segmental bronchus. Multiple biopsies were performed through bronchoscopy, and the diagnosis of a mucoepidermoid carcinoma of the lung was obtained. A left upper lobectomy was performed. The histopathological examination confirmed the preoperative diagnosis and stage (pT1N0M0). No further therapies were employed, given the stage of the disease. The patient is presently free of disease, approximately three years after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>The treatment of MECs is usually surgical by traditional or sleeve lobectomy, performed with an open or video-assisted technique, with the aim of an R0 resection. In this stage the prognosis is excellent. Conversely, high grade tumors seems to be particularly aggressive, even more than other NSCLC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Low grade type of Bronchial MEC, as our case, is often characterized by an optimal clinical management and prognosis. The lack of EGFR sensitizing mutations does not preclude the use of TKIs, which may be extremely useful in patients non responsive to other therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2017.01.042","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T14:19:10Z","timestamp":1484835550000},"page":"159-162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Bronchial mucoepidermoid carcinoma"],"prefix":"10.1097","volume":"31","author":[{"given":"Alessandro G.","family":"Fois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Diana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Arcadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Marras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Crivelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Putzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio C.","family":"Ginesu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Canu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Pirina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-41-20260114","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/00000658-194511000-00005","article-title":"Muco-Epidermoid Tumors of Salivary Glands","volume":"122","author":"Stewart","year":"1945","journal-title":"Ann. Surg"},{"key":"R2-41-20260114","first-page":"335","article-title":"Bronchogenic carcinoma; an analysis of 100 autopsy cases","volume":"111","author":"Smetana","year":"1952","journal-title":"Mil Surg"},{"key":"R3-41-20260114","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.lungcan.2010.08.021","article-title":"Primary salivary gland-type lung cancer: surgical outcomes","volume":"72","author":"Kang","year":"2011","journal-title":"Lung Cancer"},{"key":"R4-41-20260114","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-7819-12-33","article-title":"Clinicopathological analysis of pulmonary mucoepidermoid carcinoma","volume":"12","author":"Shen","year":"2014","journal-title":"World J. Surg. Oncol"},{"key":"R5-41-20260114","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/2049-6958-8-45","article-title":"Lung cancer epidemiology in north sardinia, Italy","volume":"8","author":"Paliogiannis","year":"2013","journal-title":"Multidiscip. Respir. Med"},{"key":"R6-41-20260114","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clinimag.2011.03.003","article-title":"Mucoepidermoid carcinoma of the lung: common findings and unusual appearances on CT","volume":"36","author":"Li","year":"2012","journal-title":"Clin. Imaging"},{"key":"R7-41-20260114","first-page":"9","article-title":"Mucoepidermoid tumors of the bronchus: ultrastructural and immunohistochemical study. Histiogenic correlations","volume":"22","author":"S\u00e1nchez-Mora","year":"2007","journal-title":"Histol. Histopathol"},{"key":"R8-41-20260114","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1477-7819-10-232","article-title":"Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases","volume":"10","author":"Xi","year":"2012","journal-title":"World J. Surg. Oncol"},{"key":"R9-41-20260114","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/1097-0142(197109)28:3<539::AID-CNCR2820280302>3.0.CO;2-G","article-title":"Mucoepidermoid tumors of bronchial glands","volume":"28","author":"Turnbull","year":"1971","journal-title":"Cancer"},{"key":"R10-41-20260114","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.lungcan.2007.08.022","article-title":"Mucoepidermoid carcinoma of the lung: high-resolution CT and histopathologic findings in five cases","volume":"60","author":"Ishizumi","year":"2008","journal-title":"Lung Cancer"},{"key":"R11-41-20260114","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1183\/09031936.01.00275301","article-title":"The new World Health Organization classification of lung tumours","volume":"18","author":"Brambilla","year":"2001","journal-title":"Eur. Respir. J"},{"key":"R12-41-20260114","first-page":"433","article-title":"Histogenic classification of salivary tumors","volume":"92","author":"Eversole","year":"1971","journal-title":"Arch. Pathol"},{"key":"R13-41-20260114","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1002\/1097-0142(197905)43:5<1720::AID-CNCR2820430523>3.0.CO;2-Q","article-title":"Mucoepidermoid carcinoma of the bronchus: an electron microscopic study of the low grade and the high grade variants","volume":"43","author":"Klacsmann","year":"1979","journal-title":"Cancer"},{"key":"R14-41-20260114","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0300-9785(86)80066-7","article-title":"Histologic evaluation of myoepithelial participation in salivary gland tumors","volume":"15","author":"Nikai","year":"1986","journal-title":"Int. J. Oral Maxillofac. Surg"},{"key":"R16-41-20260114","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lungcan.2007.11.014","article-title":"Mucoepidermoid carcinoma of lung: potential target of EGFR-directed treatment","volume":"61","author":"Han","year":"2008","journal-title":"Lung Cancer"},{"key":"R17-41-20260114","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.bjc.6604430","article-title":"Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma","volume":"99","author":"Dahse","year":"2008","journal-title":"Br. J. Cancer"},{"key":"R18-41-20260114","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lungcan.2009.01.003","article-title":"Gefitinib as targeted therapy for mucoepidermoid carcinoma of the lung: possible significance of CRTC1-MAML2 oncogene","volume":"64","author":"O'Neill","year":"2009","journal-title":"Lung Cancer"},{"key":"R19-41-20260114","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1158\/0008-5472.CAN-05-1125","article-title":"Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP\/CREB regulated genes","volume":"65","author":"Coxon","year":"2005","journal-title":"Cancer Res"},{"key":"R20-41-20260114","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1158\/1078-0432.CCR-08-0957","article-title":"Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers","volume":"14","author":"Yonesaka","year":"2008","journal-title":"Clin. Cancer Res"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217300457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217300457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201731000-00041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:01:08Z","timestamp":1768395668000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201731000-00041"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2017.01.042","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}