{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:58:40Z","timestamp":1768435120379,"version":"3.49.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n INTRODUCTION:<\/jats:title>\n Inguinal lymph nodes are the frequent sites of metastasis for malignant lymphoma, squamous cell carcinoma of anal canal, vulva and penis, malignant melanoma and squamous cell carcinoma of skin over lower extremities or trunk. Anatomically, endometrial carcinoma is less likely to spread to the superficial or deep inguinal lymph nodes, thus metastatic involvement of these lymph nodes can easily be overlooked.<\/jats:p>\n <\/jats:sec>\n \n CASE PRESENTATION:<\/jats:title>\n Here-in we report a case of a 65-year old Saudi morbid obese female, who presented with left inguinal lymphadenopathy as initial delayed site of metastasis almost 19 months after the initial treatment for FIGO IA endometrial carcinoma. Patient underwent left inguinal lymph node dissection. Histopathology confirmed metastatic endometrial adenocarcinoma, positive for cytokeratin (CK-7), estrogen receptor (ER) and progesterone receptors (PR), negative for CK-20 and CDX2. Following the post-surgery recovery, she was given extended field radiation therapy to para-aortic, pelvis and bilateral inguinal lymph nodes with concurrent cisplatin chemotherapy followed by high dose rate brachytherapy.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Inguinal lymph nodes as delayed site of metastasis in early endometrial carcinoma is extremely rare entity. Incorporation of FDG-PET during the preoperative screening of inguinal nodes may be helpful. The impact of lymph node dissection and adjuvant radiation therapy on survival needs to be established.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2017.01.045","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T14:17:14Z","timestamp":1484835434000},"page":"12-15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Inguinal lymph node presenting as the delayed site of metastasis in early stage endometrial carcinoma"],"prefix":"10.1097","volume":"32","author":[{"given":"Shomaila Amir M.","family":"Akbar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutahir A.","family":"Tunio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"AlShakweer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AbdulAziz","family":"AlObaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mushabbab","family":"AlAsiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20260114","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/gyno.2001.6550","article-title":"Predictors of lymphatic failure in endometrial cancer","volume":"84","author":"Mariani","year":"2002","journal-title":"Gynecol. Oncol"},{"key":"R2-4-20260114","first-page":"2531","article-title":"Inguinal lymph node metastasis as the presenting symptom of endometrial cancer: a case report","volume":"22","author":"Scholz","year":"2002","journal-title":"Anticancer Res"},{"key":"R3-4-20260114","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1245\/s10434-014-3663-0","article-title":"Distribution of lymph node metastasis sites in endometrial cancer undergoing systematic pelvic and para-aortic lymphadenectomy: a proposal of optimal lymphadenectomy for future clinical trials","volume":"21","author":"Odagiri","year":"2014","journal-title":"Ann. Surg. Oncol"},{"key":"R4-4-20260114","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/gyno.1996.0082","article-title":"An atypical recurrence of endometrial carcinoma following estrogen replacement therapy","volume":"60","author":"Carr","year":"1996","journal-title":"Gynecol. 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Oncol"},{"key":"R8-4-20260114","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1136\/bmj.330.7490.538-b","article-title":"Surgical management of metastatic inguinal lymphadenopathy: the term deep inguinal nodes should be abandoned","volume":"330","author":"Gibson","year":"2005","journal-title":"BMJ"},{"key":"R9-4-20260114","first-page":"1891","article-title":"Magnetic resonance imaging for the pre-surgical assessment of endometrial cancer: results in a routine clinical setting, outside dedicated trials; a cross-sectional study","volume":"36","author":"Arnaiz","year":"2016","journal-title":"Anticancer Res"},{"key":"R10-4-20260114","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/RLU.0000000000000852","article-title":"Staging of high-risk endometrial cancer with PET\/CT and sentinel lymph node mapping","volume":"40","author":"Signorelli","year":"2015","journal-title":"Clin. Nucl. 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Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217300482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217300482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201732000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:44:00Z","timestamp":1768398240000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201732000-00004"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2017.01.045","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}