{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:02:13Z","timestamp":1781128933301,"version":"3.54.1"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Wegener\u2019s granulomatosis (WG) is a systemic vasculitis that can affect a variety of organs including ear, nose and throat, lungs and kidneys. However WG is unusual in the pituitary and rare in the central nervous system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PRESENTATION OF CASE:<\/jats:title>\n                    <jats:p>A 56-year-old male with likely WG presented with polyuria and polydipsia despite six months of conservative medical management. MRI scanning revealed an enlarging heterogeneously enhancing pituitary gland. Following endoscopic transsphenoidal pituitary biopsy and debulking, final tissue pathology was diagnostic for WG in the pituitary gland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Diagnosis remains difficult but most patients present with central diabetes insipidus (CDI) as well as varying degrees of hypopituitarism on a background of disease activity in other organs. Clinical judgment needs to balance the need for invasive surgical tissue diagnosis with increasing immunosuppressive therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>It is important to consider this rare complication of WG to ensure timely diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2017.02.014","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T04:01:08Z","timestamp":1487649668000},"page":"24-26","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Rare presentation of Wegener\u2019s granulomatosis in the pituitary gland"],"prefix":"10.1097","volume":"33","author":[{"given":"Samantha M.","family":"Baird","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upasna","family":"Pratap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice P.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Maartens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20260114","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11102-007-0021-2","article-title":"Pituitary involvement in Wegener\u2019s granulomatosis","volume":"11","author":"Yong","year":"2007","journal-title":"Pituitary"},{"key":"R2-7-20260114","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1590\/S0004-27302011000700008","article-title":"Panhypopituitarism due to Wegener\u2019s granulomatosis","volume":"55","author":"Santoro","year":"2011","journal-title":"Arq. Bras. Endocrinol. Metab"},{"key":"R3-7-20260114","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.1210\/jc.2014-1962","article-title":"Pituitary dysfunction in granulomatosis with polyangiitis: the mayo clinic experience","volume":"99","author":"Kapoor","year":"2014","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"R4-7-20260114","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.clineuro.2012.06.041","article-title":"Hypophyseal Wegener\u2019s granulomatosis presenting by visual field constriction without hypopituitarism","volume":"115","author":"Pereira","year":"2013","journal-title":"Clin. Neurol. Neurosurg"},{"key":"R6-7-20260114","first-page":"332","article-title":"Respirato-renal type of polyarteritis nodosa. Acta Med.","volume":"323-","author":"Ahlstrom","year":"1953","journal-title":"Scand"},{"key":"R7-7-20260114","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10067-005-0065-5","article-title":"Combined CNS and pituitary involvement as a primary manifestation of Wegener granulomatosis","volume":"25","author":"\u0160p\u00ed\u0161ek","year":"2005","journal-title":"Clin. Rheumatol"},{"key":"R8-7-20260114","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.0953-8194.2004.01183.x","article-title":"Magnetic resonance imaging of the hypothalamic-Neurohypophyseal system","volume":"16","author":"Fujisawa","year":"2004","journal-title":"J. Neuroendocrinol"},{"key":"R9-7-20260114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP12181.CR","article-title":"Refractory pituitary granulomatosis with polyangiitis (Wegener\u2019s) treated with rituximab","volume":"19","author":"Hughes","year":"2015","journal-title":"Endocr. 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