{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:01:33Z","timestamp":1768435293660,"version":"3.49.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T00:00:00Z","timestamp":1500681600000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>We present a case of Alkaptonuria (AKU) presented with severe lower urinary tract symptoms (LUTS) secondary to extensive prostatic calculi deposited in the para prostatic diverticulum. Prostatic calculi are seen in chronic prostatitis, chronic pelvic pain syndrome and benign prostate hyperplasia; however, in patients with AKU, prostatic calculi and\/or calcifications are more extensive. A para prostatic diverticulum is a rare entity in males; however, it should be considered in patients with AKU based on this case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DIAGNOSIS, THERAPEUTIC INTERVENTIONS, AND OUTCOMES:<\/jats:title>\n                    <jats:p>A patient with AKU presented with extensive prostatic calculi that were deposited in para prostatic diverticulum, urethra and urinary bladder. The stones were successfully managed endoscopically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Paraprostatic diverticula or urethral diverticula are rare entities. They may be congenital or acquired due to recurrent Urinary Tract Infections (UTIs) or distal urethral obstruction. The distal obstruction of the urethra secondary to stones was the most likely etiology of the paraprostatic diverticulum in our case. The possible mechanisms behind stone formation in our case were chronic stasis and urinary infection within a urethral diverticulum proximal to the urethral obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>This case sums a rare case of AKU and paraprostatic diverticular stones; in addition, it highlights the role endoscopic management of prostatolithiasis in AKU patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2017.07.041","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T07:46:25Z","timestamp":1500968785000},"page":"192-195","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["A rare presentation of alkaptonuria"],"prefix":"10.1097","volume":"38","author":[{"given":"Husam M.F.","family":"Masoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussam H.","family":"Alhawari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nosibah T.","family":"Alryalat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muayyad M.","family":"Murshidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujalli M.","family":"Murshidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-46-20260114","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10545-008-0984-9","article-title":"Garrods Croonian lectures (1908) and the charter \u201cInborn Errors of Metabolism\u201d: albinism, alkaptonuria, cystinuria and pentosuria at age 100 in 2008","volume":"31","author":"Scriver","year":"2008","journal-title":"J. Inherit. Metab. Dis"},{"key":"R2-46-20260114","first-page":"334","article-title":"Alkaptunuria: a very rare metabolic disorder","volume":"50","author":"Aquaron","year":"2013","journal-title":"Indian J. Biochem. Biophys"},{"key":"R3-46-20260114","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1007\/s00296-011-2219-x","article-title":"Identification of forty cases with alkaptonuria in one village in Jordan","volume":"32","author":"Al-Sbou","year":"2012","journal-title":"Rheumatol. Int"},{"key":"R4-46-20260114","first-page":"141","article-title":"Prostatic calculi","volume":"95","author":"S\u00f8ndergaard","year":"1987","journal-title":"Acta Pathol. Microbiol. Immunol. Scand. A"},{"key":"R5-46-20260114","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.eururo.2003.09.020","article-title":"Clinical correlation of prostatic lithiasis with chronic pelvic pain syndromes in young adults","volume":"45","author":"Geramoutsos","year":"2004","journal-title":"Eur. 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Endourol"},{"key":"R8-46-20260114","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/j.1464-410X.2009.08348.x","article-title":"A tertiary experience of urethral diverticulectomy: diagnosis, imaging and surgical outcomes","volume":"103","author":"Ockrim","year":"2009","journal-title":"BJU Int"},{"key":"R9-46-20260114","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1464-410X.2003.04660.x","article-title":"Urethral calculi: presentation and management","volume":"93","author":"Kamal","year":"2004","journal-title":"BJU Int"},{"key":"R11-46-20260114","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0022-5347(17)53332-7","article-title":"Congenital polyp of the posterior urethra and vesical calculus in a boy","volume":"128","author":"Dalens","year":"1982","journal-title":"J. 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Surg"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217303644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261217303644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201738000-00046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:37:19Z","timestamp":1768397839000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201738000-00046"}},"subtitle":["Extensive prostatic calculi with highlight of stones found in a unique paraprostatic urethral diverticulum"],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":12,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2017.07.041","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}