{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:28:30Z","timestamp":1768433310079,"version":"3.49.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Split Hand-Foot malformation (SHFM) is a congenital limb defect that affects the central rays of the hands and\/or feet. It is a rare condition that has genetic and environmental etiologies. It ranges in severity depending on the extent of the malformation. We report on two siblings with severe SHFM affecting all limbs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We described two cases of siblings with SHFM and discuss the possible causes of the condition. This research did not require ethical approval due to the institute not requiring it for this type of study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Case 1 is a 7-year-old boy, and case 2 is his 4-year-old brother. They are both medically and surgically free. They had normal growth and development and were products of a consanguineous marriage. They both presented with bilateral deformities of the hands and feet, and had no previous family history of congenital anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SHFM may occur as a result of consanguineous marriage, genetic mutation, and chemical exposure. Genetic counseling and thorough assessment of associated anomalies is mandatory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2017.12.030","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T03:23:14Z","timestamp":1514344994000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Bilateral split hand foot malformation in siblings"],"prefix":"10.1097","volume":"44","author":[{"given":"Mohammed","family":"Ashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehab","family":"Assur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basim","family":"Awan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hattan","family":"Aljaaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-29-20260114","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1399-0004.2005.00530.x","article-title":"Split hand foot malformation (SHFM)","volume":"68","author":"Elliott","year":"2005","journal-title":"Clin. Genet"},{"key":"R2-29-20260114","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/ajmg.a.31245","article-title":"Clinical and epidemiological findings in patients with central ray deficiency: split hand foot malformation (SHFM) in Manitoba, Canada","volume":"140A","author":"Elliott","year":"2006","journal-title":"Am. J. Med. Genet"},{"key":"R3-29-20260114","first-page":"320","article-title":"Prevalence of congenital split hand\/split foot malformation in Chinese population","volume":"41","author":"Dai","year":"2010","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"R4-29-20260114","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/jmedgenet-2011-100556","article-title":"Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation","volume":"49","author":"Shamseldin","year":"2012","journal-title":"J. Med. 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