{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T22:57:26Z","timestamp":1768431446538,"version":"3.49.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Synchronous primary carcinomas of gallbladder are extremely rare. In this paper, we report a case of double primary carcinomas in gallbladder<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report:<\/jats:title>\n                    <jats:p>A 65 year old male was admitted to the hospital for surgical removal of gallbladder, which was diagnosed as cholecystitis in ultrasonography. Macroscopic examination disclosed a single whitish mass in gallbladder neck and another distinct mass in the fundus as wall thickening. Pathologic findings revealed squamous cell carcinoma of the neck and adenocarcinoma in the fundus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This study represents an example of misdiagnosis. Being cautious is mandatory in order to manage the patient properly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Synchronous primary carcinomas of gallbladder are rare. However this diagnosis should be taken into account in patients with cholecystitis features in order to seeking for the best surgical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2018.02.039","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T03:26:30Z","timestamp":1520306790000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous gallbladder squamous cell carcinoma and adenocarcinoma, both as primary tumors in one patient"],"prefix":"10.1097","volume":"45","author":[{"given":"Amir","family":"Vahedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahzad","family":"Azimpouran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ghavidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Karbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Farhadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-1-20260114","first-page":"1209","article-title":"Epidemiology of gallbladder cancer, a synthesis of recent data","volume":"65","author":"Diehl","year":"1980","journal-title":"J. Natl. Cancer Inst"},{"key":"R2-1-20260114","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ejso.2013.02.010","article-title":"Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience","volume":"39","author":"D'Hondt","year":"2013","journal-title":"Eur. J. Surg. Oncol"},{"key":"R3-1-20260114","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1479-666X(08)80073-X","article-title":"Gallbladder cancer\u2014a comprehensive review","volume":"6","author":"Lai","year":"2008","journal-title":"Surgeon"},{"key":"R6-1-20260114","first-page":"1358","article-title":"Multiple primary malignant tumors: a survey of the literature and a statistical study","volume":"16","author":"Warren","year":"1981","journal-title":"Am. J. Cancer"},{"key":"R7-1-20260114","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0002-9610(05)81278-4","article-title":"Multiple tumors of the biliary tract","volume":"159","author":"Gertsch","year":"1990","journal-title":"Am. J. Surg"},{"key":"R8-1-20260114","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijsu.2016.01.094","article-title":"The SCARE statement: consensus-based surgical case report guidelines","volume":"27","author":"Agha","year":"2016","journal-title":"Int. J. Surg"},{"key":"R9-1-20260114","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/(SICI)1096-9098(199708)65:4<258::AID-JSO6>3.0.CO;2-4","article-title":"Synchronous primary tumors of the extrahepatic bile duct and gallbladder","volume":"65","author":"Kurosaki","year":"1997","journal-title":"J. Surg. Oncol"},{"key":"R10-1-20260114","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12957-016-0848-y","article-title":"Synchronous malignancies of the gall bladder and common bile duct: a case report","volume":"14","author":"Kodaganur","year":"2016","journal-title":"World J. Surg. Oncol"},{"key":"R11-1-20260114","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2559.1987.tb02624.x","article-title":"Adenosquamous carcinoma of the gallbladder with spindle cell features. A light microscopic and immunocytochemical study of a case","volume":"11","author":"Suster","year":"1987","journal-title":"Histopathology"},{"key":"R12-1-20260114","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.humpath.2008.07.016","article-title":"Nonneoplastic signet-ring cells in the gallbladder and uterine cervix: a potential source of overdiagnosis","volume":"40","author":"Ragazzi","year":"2009","journal-title":"Hum. Pathol"},{"key":"R13-1-20260114","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1097\/PAS.0b013e3181706237","article-title":"Cribriform carcinoma of the gallbladder: a clinicopathologic study of 7 cases","volume":"32","author":"Albores-Saavedra","year":"2008","journal-title":"Am. J. Surg. Pathol"},{"key":"R14-1-20260114","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00000478-200604000-00010","article-title":"Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cells","volume":"30","author":"Albores-Saavedra","year":"2006","journal-title":"Am. J. Surg. Pathol"},{"key":"R15-1-20260114","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.anndiagpath.2009.08.002","article-title":"Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the surveillance, epidemiology, and end results program","volume":"13","author":"Albores-Saavedra","year":"2009","journal-title":"Ann. Diagn. Pathol"},{"key":"R16-1-20260114","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/00000478-200104000-00012","article-title":"Lymphoepithelioma-like cholangiocarcinoma: an Epstein-Barr virus-associated tumor","volume":"25","author":"Jeng","year":"2001","journal-title":"Am. J. Surg. Pathol"},{"key":"R17-1-20260114","first-page":"299","article-title":"Squamous cell carcinoma of gallbladder: report of two cases and review of literatures","volume":"31","author":"Karasawa","year":"1981","journal-title":"Acta Pathol. Jpn"},{"key":"R18-1-20260114","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/1097-0142(197710)40:4+<1786::AID-CNCR2820400803>3.0.CO;2-2","article-title":"Multiple primary malignant neoplasms: historical perspectives","volume":"40","author":"Moertel","year":"1977","journal-title":"Cancer"},{"key":"R19-1-20260114","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/13651820701867802","article-title":"Simultaneous gallbladder and bile duct cancers: revisiting the pathological possibilities","volume":"10","author":"Shukla","year":"2008","journal-title":"HPB (Oxford"},{"key":"R20-1-20260114","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1477-7819-9-84","article-title":"Synchronous double primary malignant tumor of the gallbladder and liver: a case report","volume":"9","author":"Kim","year":"2011","journal-title":"World J. Surg. Oncol"},{"key":"R21-1-20260114","first-page":"838","article-title":"Synchronous double primary tumor of gall bladder and stomach: a rare case report and a review literature","volume":"3","author":"Agarwal","year":"2015","journal-title":"Sch. J. Med. Case Rep"},{"key":"R22-1-20260114","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.anndiagpath.2012.07.006","article-title":"Best immunohistochemical panel in distinguishing adenocarcinoma from squamous cell carcinoma of lung: tissue microarray assay in nested lung cancer specimens","volume":"17","author":"Kim","year":"2013","journal-title":"Ann. Diagn. Pathol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218300737?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218300737?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201845000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:07:27Z","timestamp":1768396047000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201845000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":20,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2018.02.039","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}