{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:53:12Z","timestamp":1774479192618,"version":"3.50.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":121,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction:<\/jats:title>\n In patients with a hypercoagulable state, such as patients with pulmonary embolism and\/or Budd-Chiari syndrome, the complications from multiple gene mutations are more numerous than those from a single mutation. The authors present a woman with no major prior medical history who presented with pulmonary embolism and Budd-Chiari syndrome; this enigmatic co-occurrence has never been solely reported without underlying aetiology in a patient without prior medical conditions.<\/jats:p>\n <\/jats:sec>\n \n Case presentation:<\/jats:title>\n A 20-year-old female presented to the emergency room complaining of a sudden onset of acute epigastric abdominal pain lasting for approximately 2 h. The patient's liver enzymes were severely elevated. Computed tomography of her abdomen showed thrombosed hepatic veins as well as supra-hepatic and hepatic portions of the inferior vena cava. She was becoming progressively hypotensive despite supplying intravenous fluid. Consequently, the patient received a contrast chest CT, which revealed the presence of acute pulmonary embolism; to confirm the diagnosis of a perfusion abnormality with normal ventilation, a clear radiograph in that region was obtained, denoting a V\/Q study mismatch.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Many details regarding the enigmatic mechanism behind the appearance of such a thrombotic co-occurrence in our patient are unclear. Since the anticardiolipin antibody IgG and IgM serum levels were normal, blood eosinophil count was persistently normal, and no signs of autoimmune disease were found, the diagnosis of autoimmune disease in the case under discussion is unlikely.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Adding pulmonary embolism to the list of complications associated with Budd-Chiari syndrome is highly suggested, regardless of having predisposing condition(s).<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n <\/jats:sec>","DOI":"10.1016\/j.ijscr.2018.04.030","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T17:03:12Z","timestamp":1525366992000},"page":"16-21","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["An enigmatic case presentation of Budd-Chiari syndrome with pulmonary embolism"],"prefix":"10.1097","volume":"48","author":[{"given":"A.M.","family":"Al-Sharydah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.","family":"Al-Abdulwahhab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Abu AlOla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20260114","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/hep.22772","article-title":"Vascular disorders of the liver","volume":"49","author":"DeLeve","year":"2009","journal-title":"Hepatology"},{"key":"R2-4-20260114","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7326\/0003-4819-151-3-200908040-00004","article-title":"Etiology, management, and outcome of the Budd-Chiari syndrome","volume":"151","author":"Murad","year":"2009","journal-title":"Ann. Intern. Med"},{"key":"R3-4-20260114","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/0016-5085(94)90765-X","article-title":"The changing scene of hepatic vein thrombosis: recognition of asymptomatic cases","volume":"106","author":"Hadengue","year":"1994","journal-title":"Gastroenterology"},{"key":"R4-4-20260114","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhep.2008.10.007","article-title":"Primary budd-chiari syndrome","volume":"50","author":"Valla","year":"2009","journal-title":"J. Hepatol"},{"key":"R5-4-20260114","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijsu.2016.08.014","article-title":"The SCARE statement: consensus-based surgical case report guidelines","volume":"34","author":"Agha","year":"2016","journal-title":"Int. J. Surg"},{"key":"R6-4-20260114","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/2050640615582293","article-title":"Budd-Chiari syndrome","volume":"3","author":"Martens","year":"2015","journal-title":"United Eur. Gastroenterol. J"},{"key":"R8-4-20260114","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gene.2013.11.019","article-title":"Combined genetic mutations have remarkable effect on deep venous thrombosis and\/or pulmonary embolism occurence","volume":"536","author":"Simsek","year":"2014","journal-title":"Gene"},{"key":"R9-4-20260114","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.carpath.2008.12.012","article-title":"Endomyocardial fibrosis as a cause of Budd-Chiari syndrome and fatal pulmonary embolism","volume":"19","author":"Bestetti","year":"2010","journal-title":"Cardiovasc. Pathol"},{"key":"R10-4-20260114","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/000331970405500215","article-title":"Right atrial extension of primary venous leiomyosarcoma: pulmonary embolism and Budd-Chiari syndrome at presentation: a case report","volume":"55","author":"Gowda","year":"2004","journal-title":"Angiology"},{"key":"R11-4-20260114","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/hep.24811","article-title":"1; Fibrolamellar hepatocellular carcinoma presenting with budd\u2010chiari syndrome, right atrial thrombus, and pulmonary emboli","volume":"55","author":"Asrani","year":"2012","journal-title":"Hepatology"},{"key":"R12-4-20260114","first-page":"645","article-title":"Bilateral pulmonary thromboembolism and Budd-Chiari syndrome in a patient with Crohn's disease on oral contraceptives","volume":"2009","author":"Mas","year":"2009","journal-title":"Rev. Esp. Enferm. Dig"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218301561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218301561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201848000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:16:19Z","timestamp":1768396579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201848000-00004"}},"subtitle":["An unusual syndrome with an uncommon complication"],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2018.04.030","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}