{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:32:10Z","timestamp":1770341530724,"version":"3.49.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T00:00:00Z","timestamp":1527206400000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Brenner Tumors are rare adenofibromas that are most commonly benign and discovered in post-menopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>This is a case report of a 57-year-old female with three months of progressively worsening abdominal pain due to a large abdominal mass discovered on CT scan. Surgical removal of the mass revealed a giant mucinous tumor of the ovary with an associated Brenner tumor that was discovered incidentally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Although the Brenner tumor was accurately identified in the intraoperative frozen section evaluation, the mucinous tumor was underdiagnosed by frozen section as benign when permanent section revealed borderline mucinous cystadenoma. This finding did not change the treatment course for this particular patient as she had expressed personal preference for total abdominal hysterectomy. However, underdiagnosis of frozen sections of ovarian tumors is not rare. It is unclear whether an associated Brenner tumor increases malignancy potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Further investigation is required to determine whether associated Brenner tumors found during frozen section are more highly associated with malignancy and could therefore change intraoperative and overall decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2018.05.007","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T12:39:03Z","timestamp":1527338343000},"page":"40-43","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["A case report of an incidental Brenner tumor found after resection of a large ovarian mucinous neoplasm"],"prefix":"10.1097","volume":"49","author":[{"given":"Danielle","family":"Dougherty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chibueze","family":"Onyemkpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolutope","family":"Oyasiji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R2-11-20260114","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.18203\/2320-1770.ijrcog20170600","article-title":"Brenner tumor of ovary: an incidental finding: a case report","volume":"6","author":"Jodha","year":"2017","journal-title":"Int. J. Reprod. Contraception Obstet. Gynecol"},{"key":"R3-11-20260114","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4103\/0973-1482.151858","article-title":"Brenner's tumor associated with ovarian mucinous cystadenoma reaching a huge size in postmenopausal woman","volume":"11","author":"Abbas","year":"2015","journal-title":"J. Cancer Res. Ther"},{"key":"R4-11-20260114","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijsu.2016.08.014","article-title":"The SCARE statement: consensus-based surgical case report guidelines","volume":"34","author":"Agha","year":"2016","journal-title":"Int. J. Surg"},{"key":"R5-11-20260114","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.5858\/132.11.1753","article-title":"Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with walthard cell nests: a study of 120 tumors","volume":"132","author":"Seidman","year":"2008","journal-title":"Arch. Pathol. Lab. Med"},{"key":"R6-11-20260114","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/path.4572","article-title":"Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin","volume":"237","author":"Wang","year":"2015","journal-title":"J. Pathol"},{"key":"R7-11-20260114","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/uog.11149","article-title":"Imaging in gynecological disease (7): clinical and ultrasound features of Brenner tumors of the ovary","volume":"40","author":"Dierickx","year":"2012","journal-title":"Ultrasound Obstet. Gynecol"},{"key":"R8-11-20260114","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00004728-200001000-00015","article-title":"Brenner tumor of the ovary: CT and MR findings","volume":"24","author":"Moon","year":"2005","journal-title":"J. Comput. Assist. Tomogr"},{"key":"R9-11-20260114","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ygyno.2007.06.008","article-title":"Accuracy of intraoperative frozen section analysis in borderline tumors of the ovary: A retrospective analysis of 96 cases and review of the literature","volume":"107","author":"Tempfer","year":"2007","journal-title":"Gynecol. Oncol"},{"key":"R10-11-20260114","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12957-016-0849-x","article-title":"Accuracy of intraoperative frozen section for the evaluation of ovarian neoplasms: an institutional experience","volume":"14","author":"Hashmi","year":"2016","journal-title":"World J. Surg. Oncol"},{"key":"R11-11-20260114","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1634\/theoncologist.2012-0139","article-title":"Diagnosis, treatment, and follow-up of borderline ovarian tumors","volume":"17","author":"Fischerova","year":"2012","journal-title":"Oncologist"},{"key":"R12-11-20260114","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1245\/s10434-010-1293-8","article-title":"Prognostic factors of a large retrospective series of mucinous borderline tumors of the ovary (excluding peritoneal pseudomyxoma)","volume":"18","author":"Koskas","year":"2011","journal-title":"Ann. Surg. Oncol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218301767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218301767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201849000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:37:54Z","timestamp":1768397874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201849000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":11,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2018.05.007","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}