{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:09:59Z","timestamp":1792098599731,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Surgery Case Reports"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/j.ijscr.2018.10.078","type":"journal-article","created":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T02:26:22Z","timestamp":1541816782000},"page":"281-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A surgical case of aortic stenosis with recurrent gastrointestinal bleeding: Heyde syndrome"],"prefix":"10.1097","volume":"53","author":[{"given":"Makoto","family":"Iijima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagomi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Murase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.ijscr.2018.10.078_bib0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1056\/NEJM195807242590416","article-title":"Gastrointestinal bleeding in aortic stenosis","volume":"259","author":"Heyde","year":"1958","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0010","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2491\/jjsth.24.295","article-title":"Acquired type IIA von Willebrand syndrome caused by aortic stenosis: Heyde\u2019s syndrome","volume":"24","author":"Tashiro","year":"2013","journal-title":"Jpn. J. Thromb. Hemost."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijsu.2016.08.014","article-title":"The SCARE statement: consensus-based surgical case report guidelines","volume":"34","author":"Agha","year":"2016","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0020","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1056\/NEJMcibr1205363","article-title":"From clinical observation to mechanism \u2013 Heyde\u2019s syndrome","volume":"367","author":"Loscalzo","year":"2012","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0025","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/gast.2001.21204","article-title":"Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract","volume":"120","author":"Veyadier","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijscr.2018.10.078_bib0030","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/BF01296266","article-title":"Angiodysplasia. Clinical presentation and colonoscopic diagnosis","volume":"29","author":"Richter","year":"1984","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0035","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/archinte.163.15.1821","article-title":"Increased prevalence of aortic stenosis in patients with arteriovenous malformations of the gastrointestinal tract in Heyde syndrome","volume":"163","author":"Batur","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0040","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.5551\/jat.30809","article-title":"Unexpectedly high prevalence of acquired von Willebrand syndrome in patients with severe aortic stenosis as evaluated with a novel large multimer index","volume":"22","author":"Tamura","year":"2015","journal-title":"J. Atheroscler. Thromb."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0045","first-page":"327","article-title":"Role of von Willebrand factor for the onset of arterial thrombosis","volume":"47","author":"Goto","year":"2001","journal-title":"Clin. Lab."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0055","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2169\/internalmedicine.45.1526","article-title":"Successful colectomy for the treatment of repetitive bleeding from colonic angiodysplasia in a patient with Heyde syndrome","volume":"45","author":"Ogano","year":"2006","journal-title":"Intern. Med."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0060","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jacc.2012.10.041","article-title":"Heyde\u2019s syndrome incidence and outcome in patients undergoing transcatheter aortic valve implantation","volume":"61","author":"Godino","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijscr.2018.10.078_bib0065","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtcvs.2011.05.034","article-title":"Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome","volume":"144","author":"Thompson","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218305029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261218305029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:40:15Z","timestamp":1768387215000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210261218305029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":13,"alternative-id":["S2210261218305029"],"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2018.10.078","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A surgical case of aortic stenosis with recurrent gastrointestinal bleeding: Heyde syndrome","name":"articletitle","label":"Article Title"},{"value":"International Journal of Surgery Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijscr.2018.10.078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.","name":"copyright","label":"Copyright"}]}}