{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:24:52Z","timestamp":1787793892434,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin that has potential for malignant transformation into squamous cell carcinoma (SCC). The pathogenesis of HS is poorly understood but thought to be from follicular keratinization, occlusion, and rupture of the pilosebaceous unit, followed by an infiltration of inflammatory cells into the dermis. Treatment is challenging due to a lack of effective medical therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case:<\/jats:title>\n                    <jats:p>In this case report, we describe a patient with chronic HS that developed into SCC who underwent late surgical intervention after failing medical management. At the time malignant transformation was discovered, the SCC was beyond resectability and ultimately fatal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Based on the morbidity and mortality of chronic HS illustrated in our case and presented in the literature, we advocate for early surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Wide surgical excision offers a near definitive intervention and should at least be considered for all chronic HS patients due to high morbidity and malignant transformation risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2019.01.006","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T01:54:51Z","timestamp":1547862891000},"page":"50-53","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Infiltrative squamous cell carcinoma in hidradenitis suppurativa"],"prefix":"10.1097","volume":"55","author":[{"given":"Peter G.","family":"Juviler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20260114","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0094-1298(20)30608-8","article-title":"Hidradenitis suppurativa","volume":"14","author":"Paletta","year":"1987","journal-title":"Clin. Plast. Surg"},{"key":"R2-14-20260114","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/bjs.1800790905","article-title":"Surgical treatment of hidradenitis suppurativa","volume":"79","author":"Banerjee","year":"1992","journal-title":"Br. J. Surg"},{"key":"R4-14-20260114","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jaad.2008.06.020","article-title":"Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies","volume":"59","author":"Revuz","year":"2008","journal-title":"J. Am. Acad. Dermatol"},{"key":"R6-14-20260114","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0002-9610(49)90162-2","article-title":"Hidradenitis suppurativa; its confusion with pilonidal disease and anal fistula","volume":"77","author":"Jackman","year":"1949","journal-title":"Am. J. 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Surg"},{"key":"R10-14-20260114","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.12688\/f1000research.11337.1","article-title":"Hidradenitis suppurativa: an update on connecting the tracts","volume":"6","author":"Smith","year":"2017","journal-title":"F1000Research"},{"key":"R11-14-20260114","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1046\/j.1524-4725.2000.00043.x","article-title":"Long-term results of wide surgical excision in 106 patients with hidradenitis suppurativa","volume":"26","author":"Rompel","year":"2000","journal-title":"Dermatol. Surg"},{"key":"R12-14-20260114","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.jaad.2015.07.044","article-title":"Recurrence of hidradenitis suppurativa after surgical management: a systematic review and meta-analysis","volume":"75","author":"Mehdizadeh","year":"2015","journal-title":"J. Am. Acad. Dermatol"},{"key":"R13-14-20260114","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-5945-12-9","article-title":"A review of wide surgical excision of hidradenitis suppurativa","volume":"12","author":"Alharbi","year":"2012","journal-title":"BMC Dermatol"},{"key":"R14-14-20260114","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/BF02586399","article-title":"Surgical treatment of perianal and perineal hidradenitis suppurativa","volume":"21","author":"Thornton","year":"1978","journal-title":"Dis. Colon Rectum"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219300173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219300173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201955000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:12:09Z","timestamp":1768396329000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201955000-00014"}},"subtitle":["A case report for early surgical intervention"],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":12,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2019.01.006","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}