{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:22:42Z","timestamp":1778822562965,"version":"3.51.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Phyllodes tumors are biphasic fibroepithelial tumors that account for fewer than 1% of mammary tumors. They usually appear in middle-aged women, with an average size of 4\u20137 cm and rapid growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case<\/jats:title>\n                    <jats:p>A 25-year-old woman sought care after excision of recurrent nodules in the right breast, with a diagnosis of borderline phyllodes tumor. She had no new lesions on physical examination. Imaging studies revealed an anechoic collection and nodular areas in a previous surgical site, correlated with pathology. Immuno-histochemical examination was positive for vimentin, calponin, Ki-67 and estrogen receptor. Systemic staging did not show metastases. Skin-reducing mastectomy was performed on the right side, followed by reconstruction and left reduction mammaplasty for symmetry. At 8-month follow-up, there was no relapse of the lesions on clinical and ultrasonographic examinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Phyllodes tumors are rare neoplasms characterized by rapid growth, occurring in women between 35\u201355 years of age. They are classified as benign, borderline and malignant, according to histological parameters. There are reports of genetic mutations in TP53 associated with malignant phyllodes tumor. On immunohistochemistry, there is a greater tendency to malignancy in tumors with Ki-67 and estrogen receptor expression. Imaging methods may aid in diagnosis, which is only definitive after excision and histopathological analysis of the tumor. These tumors have high local recurrence rates and possibility of metastases, closely related to histology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Phyllodes tumors are a great challenge to the surgeon. Treatment is surgical, with wide excision; radiotherapy and chemotherapy are controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2019.05.032","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T22:22:50Z","timestamp":1559686970000},"page":"25-29","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Recurrent borderline phyllodes tumor of the breast submitted to mastectomy and immediate reconstruction"],"prefix":"10.1097","volume":"60","author":[{"given":"Bruno Bisognin","family":"Garlet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Zogbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Piveta de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Pereira de Souza","family":"Favalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Diefenthaeler","family":"Krahe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-7-20260114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejro.2018.09.002","article-title":"Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis","volume":"5","author":"Stoffel","year":"2018","journal-title":"Eur. J. Radiol. Open"},{"key":"R3-7-20260114","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.2147\/OTT.S171714","article-title":"Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review","volume":"11","author":"Wang","year":"2018","journal-title":"Onco Target. Ther"},{"key":"R4-7-20260114","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijscr.2017.12.013","article-title":"Early stage malignant phyllodes tumor case report","volume":"42","author":"Wolbert","year":"2018","journal-title":"Int. J. Surg. Case Rep"},{"key":"R5-7-20260114","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijscr.2017.11.009","article-title":"Skin-reducing mastectomy and direct-to-implant reconstruction in giant phyllodes tumour of breast: case report","volume":"41","author":"Ciancio","year":"2017","journal-title":"Int. J. Surg. Case Rep"},{"key":"R6-7-20260114","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijsu.2018.10.028","article-title":"The SCARE 2018 statement: updating consensus surgical CAse REport (SCARE) guidelines","volume":"60","author":"Agha","year":"2018","journal-title":"Int. J. Surg"},{"key":"R7-7-20260114","doi-asserted-by":"crossref","first-page":"e9069","DOI":"10.1097\/MD.0000000000009069","article-title":"Recurrent malignant phyllodes tumor of the breast: a case report","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine"},{"key":"R8-7-20260114","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes tumours of the breast: a consensus review","volume":"68","author":"Tan","year":"2016","journal-title":"Histopathology"},{"key":"R9-7-20260114","doi-asserted-by":"crossref","first-page":"e11412","DOI":"10.1097\/MD.0000000000011412","article-title":"Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women","volume":"97","author":"Abdul Hamid","year":"2018","journal-title":"Medicine"},{"key":"R10-7-20260114","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.amjsurg.2014.09.040","article-title":"Phyllodes tumors in African American women","volume":"210","author":"Bumpers","year":"2015","journal-title":"Am. J. Surg"},{"key":"R11-7-20260114","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5455\/msm.2011.23.200-205","article-title":"Phyllodes tumors of the breast","volume":"23","author":"Abusalem","year":"2011","journal-title":"Mater. Sociomed"},{"key":"R12-7-20260114","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/pmj.77.909.428","article-title":"Phyllodes tumours","volume":"77","author":"Parker","year":"2001","journal-title":"Postgrad. Med. J"},{"key":"R13-7-20260114","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/cam4.1327","article-title":"Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients","volume":"7","author":"Zhou","year":"2018","journal-title":"Cancer Med"},{"key":"R14-7-20260114","doi-asserted-by":"crossref","first-page":"e8552","DOI":"10.1097\/MD.0000000000008552","article-title":"Phyllodes tumors of the breast in 2 sisters: case report and review of literature","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine"},{"key":"R15-7-20260114","first-page":"1986","article-title":"BRCA1 mutation in breast cancer patients: analysis of prognostic factors and survival","volume":"17","author":"Huszno","year":"2019","journal-title":"Oncol. Lett"},{"key":"R16-7-20260114","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1002\/mgg3.493","article-title":"BRCA1\/BRCA2 mutations in Japanese women with ductal carcinoma in situ","volume":"7","author":"Liu","year":"2019","journal-title":"Mol. Genet. Genomic Med"},{"key":"R17-7-20260114","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.radcr.2017.06.012","article-title":"Malignant phyllodes breast tumor","volume":"12","author":"Shah-Patel","year":"2017","journal-title":"Radiol. Case Rep"},{"key":"R18-7-20260114","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.amsu.2017.02.007","article-title":"Resection and reconstruction following recurrent malignant phyllodes\u2013case report and review of literature","volume":"16","author":"Rajesh","year":"2017","journal-title":"Ann. Med. Surg"},{"key":"R19-7-20260114","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12957-018-1453-z","article-title":"Surgical excision and oncoplastic breast surgery in 32 patients with benign phyllodes tumors","volume":"16","author":"Ren","year":"2018","journal-title":"World J. Surg. Oncol"},{"key":"R20-7-20260114","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ijscr.2017.09.021","article-title":"Clinicopathology and treatment of a giant malignant phyllodes tumor of the breast: a case report and literature review","volume":"41","author":"Warner","year":"2017","journal-title":"Int. J. Surg. Case Rep"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219302792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219302792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201960000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:38:06Z","timestamp":1768397886000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201960000-00007"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2019.05.032","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}