{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T23:23:58Z","timestamp":1772925838161,"version":"3.50.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Breast cancer metastasis to the gastrointestinal (GI) tract is rare and occurs more frequently in invasive lobular carcinoma. Patients may be asymptomatic or present with variable vague symptoms that may be mistakenly attributed to side effects of chemotherapy or other benign GI diseases. Treatment follows the principles of systemic disease and includes hormonal therapy, chemotherapy and signal transduction inhibitors, with surgical intervention indicated for complications such as obstruction, perforation and hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case<\/jats:title>\n                    <jats:p>We present the case of a female patient with a history of invasive lobular breast carcinoma who had undergone mastectomy and axillary dissection, followed by chemoradiotherapy. Over the next nine years, she developed ovarian and bone metastases for which appropriate treatment was provided. A right iliac fossa mass was discovered during routine clinic review, though she remained asymptomatic. Computed tomography scan showed ileocecal intussusception. Histopathological examination of the right hemicolectomy specimen following emergency surgery confirmed metastatic invasive lobular carcinoma to the GI tract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>GI tract metastasis may present 30 years after the primary breast cancer. Up to 20% of patients may be asymptomatic as shown by Montagna et al. When present, symptoms are commonly non-specific and vague. Histological diagnosis is challenging. GI metastasis typically appears as intramural infiltration of the bowel wall by small cells arranged in cords.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is important to maintain a suspicion for GI tract metastasis in breast cancer patients who present with abdominal mass or GI symptoms, as this aids in prompt institution of accurate and appropriate management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2019.10.003","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T01:34:21Z","timestamp":1570412061000},"page":"109-112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Gastrointestinal tract metastasis presenting as intussusception in invasive lobular carcinoma of the breast"],"prefix":"10.1097","volume":"64","author":[{"given":"Joanne Aisha","family":"Mosiun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Syafiq bin","family":"Idris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ying","family":"Teoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Sze","family":"Teh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Ann","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee Hoong","family":"See","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-26-20260114","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02234749","article-title":"Rectal localization of metastatic lobular breast cancer","volume":"44","author":"Cervi","year":"2001","journal-title":"Dis. Colon Rectum"},{"key":"R2-26-20260114","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2214\/ajr.175.3.1750795","article-title":"Metastatic lobular carcinoma of the breast: patterns of spread in the chest, abdomen, and pelvis on CT","volume":"175","author":"Winston","year":"2000","journal-title":"Am. J. Roentgenol"},{"key":"R3-26-20260114","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0016-5107(92)70377-0","article-title":"The spectrum of gastrointestinal metastases of breast carcinoma: I. Stomach","volume":"38","author":"Taal","year":"1992","journal-title":"Gastrointest. Endosc"},{"key":"R4-26-20260114","doi-asserted-by":"crossref","first-page":"6219","DOI":"10.3748\/wjg.v12.i38.6219","article-title":"Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature","volume":"12","author":"Nazareno","year":"2006","journal-title":"World J. Gastroenterol"},{"key":"R5-26-20260114","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1200\/JCO.1998.16.11.3711","article-title":"Large bowel mucosal metastases from breast cancer","volume":"16","author":"Van Halteren","year":"1998","journal-title":"J. Clin. Oncol"},{"key":"R6-26-20260114","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1572-0241.1998.111_c.x","article-title":"Metastatic breast cancer masquerading as gastrointestinal primary","volume":"93","author":"Schwarz","year":"1998","journal-title":"Am. J. Gastroenterol"},{"key":"R7-26-20260114","first-page":"175","article-title":"Gastric metastasis of breast cancer occurring after a cancer-free interval of 30 years","volume":"28","author":"Benfiguig","year":"1992","journal-title":"Ann. Gastroenterol. Hepatol. (Paris"},{"key":"R8-26-20260114","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijsu.2018.10.028","article-title":"The SCARE 2018 statement: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"60","author":"Agha","year":"2018","journal-title":"Int. J. Surg"},{"key":"R9-26-20260114","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/jama.289.11.1421","article-title":"Trends in incidence rates of invasive lobular and ductal breast carcinoma","volume":"289","author":"Li","year":"2003","journal-title":"JAMA"},{"key":"R10-26-20260114","first-page":"637","article-title":"Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast","volume":"114","author":"Borst","year":"1993","journal-title":"Surgery"},{"key":"R11-26-20260114","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1309\/CPUX-KWEH-7B26-YE19","article-title":"Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguish lobular from ductal breast carcinoma","volume":"114","author":"Lehr","year":"2000","journal-title":"Am. J. Clin. Pathol"},{"key":"R12-26-20260114","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/bcr767","article-title":"Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome","volume":"6","author":"Arpino","year":"2004","journal-title":"Breast Cancer Res"},{"key":"R13-26-20260114","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.clbc.2017.07.003","article-title":"Lobular metastatic breast cancer patients with gastrointestinal involvement: features and outcomes","volume":"18","author":"Montagna","year":"2017","journal-title":"Clin. Breast Cancer"},{"key":"R14-26-20260114","first-page":"37","article-title":"Case series of 21 patients with extrahepatic metastatic lobular breast carcinoma to the gastrointestinal tract","volume":"3","author":"Switzer","year":"2015","journal-title":"Cancer Treat. Commun"},{"key":"R15-26-20260114","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/tbj.12464","article-title":"Gastrointestinal metastases from breast cancer, a comprehensive review","volume":"21","author":"Wiisanen","year":"2015","journal-title":"Breast J"},{"key":"R16-26-20260114","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1023\/A:1008287007819","article-title":"Abdominal pain with anorexia in patients with breast carcinoma","volume":"9","author":"Van Trappen","year":"1998","journal-title":"Ann. Oncol"},{"key":"R17-26-20260114","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/030089160509100509","article-title":"Single colon metastasis from breast cancer: a clinical case report","volume":"91","author":"Signorelli","year":"2005","journal-title":"Tumori"},{"key":"R18-26-20260114","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1034\/j.1600-0463.2000.d01-84.x","article-title":"The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract","volume":"108","author":"Tot","year":"2000","journal-title":"Acta Pathol. Microbiol. Immunol. Scand"},{"key":"R19-26-20260114","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/S12094-010-0481-0","article-title":"Rectal metastasis from lobular breast carcinoma 15 years after primary diagnosis","volume":"12","author":"Deogracias","year":"2010","journal-title":"Clin. Transl. Oncol"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219305474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261219305474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01612930-201964000-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:21:13Z","timestamp":1768396873000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01612930-201964000-00026"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":19,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2019.10.003","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}