{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:22:42Z","timestamp":1786990962284,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although uncommon, neoplasms of the appendix do exist. The two most common types are neuroendocrine tumors and mucinous appendiceal neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In two patients unusual gross and microscopic findings in an appendectomy specimen were recorded. Special immunocytochemistry studies were used to determine the histologic type of the tumors in the appendix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The clinical features and histopathology of two patients who had both a neuroendocrine tumor and a low grade appendiceal mucinous neoplasm in the same appendectomy specimen were described. Possibilities for the causation and treatment of this unusual condition were discussed. The incidence of this double malignancy was estimated at 2.5 in 1000 appendectomy specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although extremely unusual, a neuroendocrine tumor and a mucinous appendiceal neoplasm can exist in the same appendix. This condition is reported in two young patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2020.01.022","type":"journal-article","created":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T09:31:06Z","timestamp":1580031066000},"page":"76-79","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Synchronous primary neuroendocrine and mucinous epithelial tumors present in the same appendix. Case report of 2 patients"],"prefix":"10.1097","volume":"67","author":[{"given":"Paul H.","family":"Sugarbaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almog","family":"Ben-Yaacov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hazzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviram","family":"Nissan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20260114","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.10589","article-title":"Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998","volume":"94","author":"McCusker","year":"2002","journal-title":"Cancer"},{"key":"R3-18-20260114","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejso.2007.04.002","article-title":"Appendiceal neoplasms and pseudomyxoma peritonei: a population based study","volume":"34","author":"Smeenk","year":"2008","journal-title":"Eur. 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Cancer Res"},{"key":"R10-18-20260114","first-page":"1001","article-title":"Hernia mesh is contraindicated in patients with peritoneal metastases","volume":"1","author":"Sugarbaker","year":"2018","journal-title":"JSM Surg. Proced"},{"key":"R11-18-20260114","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJM198712313172704","article-title":"Carcinoid tumor of the appendix: treatment and prognosis","volume":"317","author":"Moertel","year":"1987","journal-title":"N. Engl. J. Med"},{"key":"R12-18-20260114","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1097\/SLA.0000000000003077","article-title":"Comment on \u201cCurrent management and predictive factors of lymph node metastasis of appendix neuroendocrine tumors: a national study from the french group of endocrine tumors (GTE)\u201d","volume":"270","author":"Lamberti","year":"2019","journal-title":"Ann. Surg"},{"key":"R13-18-20260114","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jamcollsurg.2019.02.050","article-title":"Practice Patterns and Guideline Non-Adherence in Surgical Management of Appendiceal Carcinoid Tumors","volume":"228","author":"Heller","year":"2019","journal-title":"J. Am. Coll. Surg"},{"key":"R14-18-20260114","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/bjs.4393","article-title":"Right hemicolectomy does not confer a survival advantage in patients with mucinous carcinoma of the appendix and peritoneal seeding","volume":"91","author":"Gonzalez-Moreno","year":"2004","journal-title":"Br. J. Surg"},{"key":"R15-18-20260114","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1245\/s10434-016-5632-2","article-title":"When and when not to perform a right colon resection with mucinous appendiceal neoplasms","volume":"24","author":"Sugarbaker","year":"2017","journal-title":"Ann. Surg. 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