{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:45:57Z","timestamp":1768524357323,"version":"3.49.0"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We encountered a case of a large cell neuroendocrine carcinoma with bronchial intraepithelial spread, a unique form of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Presentation of case<\/jats:title>\n                    <jats:p>A 63-year-old man underwent middle lobectomy and systematic lymph node dissection for lung cancer. The pathological diagnosis was a large cell neuroendocrine carcinoma, and the pathological stage of the tumor was T2aN0M0, stage IB. At 30 months after surgery, the patient complained of continuous cough, and computed tomography revealed a thickened right upper bronchus. Transbronchial biopsy revealed a large cell neuroendocrine carcinoma with bronchial intraepithelial recurrence. The patient died of disease 24 months after recurrence was diagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In cases of centrally located small cell lung carcinoma, it is well known that tumor cells progress along the sub-bronchial mucosa. In contrast, the mechanism of tumor progression of large cell neuroendocrine carcinoma is not fully elucidated because of the rarity of such cases. Endobronchial metastases usually show the presence of polypoid lesions. To the best of our knowledge, this is the first case of endobronchial metastasis from a pulmonary large cell neuroendocrine carcinoma showing bronchial intraepithelial recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians should be aware of this unique form of recurrence in patients with large cell neuroendocrine carcinoma of the lungs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2020.01.058","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T11:51:15Z","timestamp":1580989875000},"page":"183-186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Bronchial intraepithelial recurrence of a pulmonary large cell neuroendocrine carcinoma"],"prefix":"10.1097","volume":"67","author":[{"given":"Hideaki","family":"Kojima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Funai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Ohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-46-20260114","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00000478-199106000-00003","article-title":"Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical, and flow cytometric study of 35 cases","volume":"15","author":"Travis","year":"1991","journal-title":"Am. J. Surg. Pathol"},{"key":"R3-46-20260114","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.athoracsur.2015.12.009","article-title":"A single-institution analysis of the surgical management of pulmonary large cell neuroendocrine carcinomas","volume":"101","author":"Roesel","year":"2016","journal-title":"Ann. Thorac. Surg"},{"key":"R5-46-20260114","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/JTO.0000000000000616","article-title":"High-grade neuroendocrine carcinoma with bronchial intraepithelial tumor spread: possibly a new histologic feature of large-cell neuroendocrine carcinoma","volume":"10","author":"Kojima","year":"2015","journal-title":"J. Thorac. Oncol"},{"key":"R6-46-20260114","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1378\/chest.119.3.768","article-title":"Endotracheral\/endobronchial metastases: clinicopathologic study with special reference to developmental nodes","volume":"119","author":"Kiryu","year":"2001","journal-title":"Chest"},{"key":"R7-46-20260114","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.rmedc.2008.01.002","article-title":"Endobronchial metastasis from slow-growing lung cancer: a rare case report and review of the literature","volume":"1","author":"Yokoba","year":"2008","journal-title":"Respir. Med. CME"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261220300742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261220300742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2020.01.058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:30:07Z","timestamp":1768397407000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2020.01.058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":5,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2020.01.058","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}