{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:42:44Z","timestamp":1768434164401,"version":"3.49.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Painful tip penile ischemic lesion that varies from ulceration to dry gangrene which is calcified in a patient with ESRD on chronic dialysis is a seriously complicated disease due to microvascular disease of subcutaneous and adipose tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>72 gentleman who is on chronic dialysis for the last 8 years because of ESRD, In which he developed many vascular disease and amputation done for him presented with spreading black painful areas at the tip of the glans for which conservative treatment took place for about month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The diagnosis and management of this rare disease still unclear. Diagnosis mostly clinical, treatment conservative versus surgical.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Controversies of for penile Calciphylaxis diagnosis and treatment for its rarity, high mortality rate, and as its part of systematic disease treatment till know individualized according to patient status and extent of the necrotic area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2020.10.097","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:03:32Z","timestamp":1604534612000},"page":"187-190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Penile calciphylaxis diagnosis and treatment challenges a case report"],"prefix":"10.1097","volume":"77","author":[{"given":"Morad","family":"Bani-Hani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sager","family":"Nawafleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al-zubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Alkhatatbeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Altal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Yahia","family":"Sarhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah Tewfik","family":"Daradkeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulieman","family":"Alriyalat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakher","family":"Tahaineh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-44-20260114","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMra1505292","article-title":"Calciphylaxis","volume":"378","author":"Nigwekar","year":"2018","journal-title":"N. Engl. J. Med"},{"key":"R2-44-20260114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/qjmed\/hcy234","article-title":"Review: update on the management of calciphylaxis","volume":"112","author":"Seethapathy","year":"2019","journal-title":"QJM"},{"key":"R3-44-20260114","doi-asserted-by":"crossref","first-page":"e232138","DOI":"10.1136\/bcr-2019-232138","article-title":"Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge","volume":"12","author":"David","year":"2019","journal-title":"BMJ Case Rep"},{"key":"R4-44-20260114","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5489\/cuaj.2331","article-title":"Penile lesion in end-stage renal failure - cancer or otherwise?: calcific uremic arteriolopathy presenting with a penile lesion","volume":"9","author":"Malthouse","year":"2015","journal-title":"Can. Urol. Assoc. J"},{"key":"R5-44-20260114","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1515\/med-2018-0025","article-title":"Penile calciphylaxis in a patient with end-stage renal disease: a case report and review of the literature","volume":"13","author":"Yang","year":"2018","journal-title":"Open Med. (Wars"},{"key":"R7-44-20260114","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1308\/rcsann.2019.0119","article-title":"Penile calciphylaxis: a conservative approach","volume":"102","author":"El-Taji","year":"2020","journal-title":"Ann. R. Coll. Surg. Engl"},{"key":"R8-44-20260114","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijscr.2020.04.091","article-title":"Penile necrosis by calciphylaxis leading to gangrene in a patient with chronic renal failure on dialysis: a case report","volume":"71","author":"Kouiss","year":"2020","journal-title":"Int. J. Surg. Case Rep"},{"key":"R9-44-20260114","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s13730-019-00439-8","article-title":"Multidisciplinary management of calciphylaxis: a series of 5 patients at a single facility","volume":"9","author":"Saito","year":"2020","journal-title":"CEN Case Rep"},{"key":"R10-44-20260114","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1097\/01.ju.0000064334.85656.a1","article-title":"Penile calciphylaxis: analysis of risk factors and mortality","volume":"169","author":"Karpman","year":"2003","journal-title":"J. Urol"},{"key":"R11-44-20260114","first-page":"113","article-title":"Penile calciphylaxis: the use of radiological investigations in the management of a rare and challenging condition","volume":"13","author":"Campbell","year":"2017","journal-title":"Urol. 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