{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:01:35Z","timestamp":1768438895728,"version":"3.49.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"C","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Undifferentiated carcinoma (UC) of the liver has only been reported in three adults in the English language literature and is so rare it has never been reported in a child. Our management is presented to improve knowledge of its treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 3-year-old previously well Japanese girl was referred for further assessment\/management of an abdominal mass. On examination an obvious right hypocostal mass was visible extending across the midline. Diagnostic imaging identified a 12.5 cm mass on the ventral surface of the liver containing multiple cystic lesions extending along Glisson\u2019s capsule with invasion to the portal vein. Open biopsy eventually led to a diagnosis of poorly differentiated or UC of the liver with embryonal features. Resection of hepatic segments 4b and 5 after a remarkable initial response to cisplatin\/doxorubicin that shrank the tumor substantially, separating it from Glisson\u2019s capsule enabled total excision. Surgery was successful and tolerated well with unremarkable postoperative recovery. Unfortunately, ascites due to peritoneal carcinomatosis developed 4 months postoperatively and she died 5 months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The initial impressive response to neoadjuvant chemotherapy and successful surgery was unexpectedly fortuitous but inadequate for controlling such an aggressive malignancy. Our case demonstrates the value of neoadjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijscr.2020.11.153","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T12:14:42Z","timestamp":1606911282000},"page":"67-70","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Undifferentiated carcinoma of the liver in a 3-year-old girl treated by neoadjuvant chemotherapy and complete resection"],"prefix":"10.1097","volume":"78","author":[{"given":"Takanori","family":"Ochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey J.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuyuki","family":"Yamataka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Saiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-16-20260114","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jjco\/28.6.401","article-title":"Undifferentiated carcinoma of the liver with neuroendocrine features: a case report","volume":"28","author":"Nakasuka","year":"1998","journal-title":"Jpn. J. Clin. Oncol"},{"key":"R2-16-20260114","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40792-017-0288-0","article-title":"Undifferentiated carcinoma of the liver: a case report with immunohistochemical analysis","volume":"3","author":"Maeda","year":"2017","journal-title":"Surg. Case Rep"},{"key":"R3-16-20260114","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijscr.2018.07.047","article-title":"A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: a case report and literature review","volume":"51","author":"Hiraki","year":"2018","journal-title":"Int. J. Surg. Case Rep"},{"key":"R4-16-20260114","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.crad.2013.12.021","article-title":"CT volumetry of the liver: where does it stand in clinical practice?","volume":"69","author":"Lim","year":"2014","journal-title":"Clin. Radiol"},{"key":"R5-16-20260114","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archsurg.137.6.675","article-title":"Extended hepatectomy in patients with hepatobiliary malignancies with and without preoperative portal vein embolization","volume":"137","author":"Abdalla","year":"2002","journal-title":"Arch. Surg"},{"key":"R6-16-20260114","first-page":"123","article-title":"PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group","volume":"2007","author":"Roebuck","year":"2005","journal-title":"Pediatr. Radiol"},{"key":"R7-16-20260114","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1056\/NEJMoa0810613","article-title":"Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma","volume":"361","author":"Perilongo","year":"2009","journal-title":"N. Engl. J. Med"},{"key":"R8-16-20260114","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S1470-2045(13)70272-9","article-title":"Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study","volume":"14","author":"Zsiros","year":"2013","journal-title":"Lancet Oncol"},{"key":"R9-16-20260114","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijsu.2018.10.028","article-title":"The SCARE 2018 statement: updating consensus Surgical CAse REport (SCARE) guidelines","volume":"60","author":"Agha","year":"2018","journal-title":"Int. J. Surg"},{"key":"R10-16-20260114","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jamasurg.2015.1847","article-title":"Effect of liver transplant on long-term disease-free survival in children with hepatoblastoma and hepatocellular cancer","volume":"150","author":"Pham","year":"2015","journal-title":"JAMA Surg"},{"key":"R11-16-20260114","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/lt.23803","article-title":"Nationwide survey of the outcomes of living donor liver transplantation for hepatoblastoma in Japan","volume":"20","author":"Sakamoto","year":"2014","journal-title":"Liver Transpl"},{"key":"R12-16-20260114","doi-asserted-by":"crossref","first-page":"e27383","DOI":"10.1002\/pbc.27383","article-title":"Surgical treatment strategy for advanced hepatoblastoma: resection versus transplantation","volume":"65","author":"Uchida","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"R13-16-20260114","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/SLA.0000000000001936","article-title":"POST-TEXT III and IV hepatoblastoma: extended hepatic resection avoids liver transplantation in selected cases","volume":"266","author":"Fuchs","year":"2017","journal-title":"Ann. Surg"},{"key":"R14-16-20260114","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1002\/cncr.25722","article-title":"Successful nontransplant resection of POST-TEXT III and IV hepatoblastoma","volume":"117","author":"Lautz","year":"2011","journal-title":"Cancer"}],"container-title":["International Journal of Surgery Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261220311822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210261220311822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2020.11.153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:48:37Z","timestamp":1768398517000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1016\/j.ijscr.2020.11.153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":14,"journal-issue":{"issue":"C","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijscr.2020.11.153","relation":{},"ISSN":["2210-2612"],"issn-type":[{"value":"2210-2612","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}